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Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

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1. scibot 23 Dec 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.biopha.2025.118937
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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sciencedirect.com/science/article/pii/S075333222501131X
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules

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1. scibot 15 Nov 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1021/acsomega.5c10222
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12612902/
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Identification of a First-In-Class Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry Screening

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1. scibot 11 Nov 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1101/2025.11.05.686689
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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biorxiv.org/content/10.1101/2025.11.05.686689v1
Oct 2025
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Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models

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1. scibot 01 Oct 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.ejmech.2025.118194
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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sciencedirect.com/science/article/pii/S0223523425009596
Aug 2025
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Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders

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1. scibot 09 Aug 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.slasd.2025.100256
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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sciencedirect.com/science/article/pii/S2472555225000498
Jul 2025
www.biorxiv.org www.biorxiv.org

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules

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1. scibot 12 Jul 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1101/2025.06.12.659248
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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biorxiv.org/content/10.1101/2025.06.12.659248v1
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High throughput screening assay for the identification of ATF4 and TFEB activating compounds

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1. scibot 22 May 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1080/27694127.2025.2473765
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980509/
Feb 2025
www.cell.com www.cell.com

Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies

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1. scibot 13 Feb 2025
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.str.2025.01.019
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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cell.com/structure/fulltext/S0969-2126(25)00019-X
Aug 2024
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A new generation of nanobody research tools using improved mass spectrometry-based discovery methods

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1. scibot 19 Aug 2024
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.jbc.2024.107623
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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sciencedirect.com/science/article/pii/S0021925824021240
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

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1. scibot 10 May 2024
  
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  RRID:SCR_020985
  
  DOI: 10.7554/eLife.89423
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11076045/
Feb 2024
www.biorxiv.org www.biorxiv.org

New submission 08/11/2023, 05:43:36

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1. scibot 11 Feb 2024
  
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  RRID:SCR_020985
  
  DOI: 10.1101/2023.07.14.549041
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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biorxiv.org/content/10.1101/2023.07.14.549041v2
Oct 2023
www.biorxiv.org www.biorxiv.org

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies

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1. scibot 27 Oct 2023
  
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  RRID:SCR_020985
  
  DOI: 10.1101/2023.10.22.563475
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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biorxiv.org/content/10.1101/2023.10.22.563475v1
Nov 2021
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An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance

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1. scibot 24 Nov 2021
  
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  RRID:SCR_020985
  
  DOI: 10.1016/j.chembiol.2021.11.004
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
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sciencedirect.com/science/article/pii/S2451945621004815