Hypothesis

15 Matching Annotations

Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TREM2 hit discovery using temperature-related intensity change (TRIC) technology: A proof-of-concept high-throughput screening approach

1
1. scibot 12 Feb 2026
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.slasd.2025.100255
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12888892/
Jan 2026
www.biorxiv.org www.biorxiv.org

First-in-Class Small Molecule ROBO2 Binders Identified through Integrated Virtual Screening and Biophysical Validation

1
1. scibot 16 Jan 2026
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.64898/2026.01.05.697640
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

biorxiv.org/content/10.64898/2026.01.05.697640v1
Dec 2025
www.sciencedirect.com www.sciencedirect.com

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

1
1. scibot 23 Dec 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.biopha.2025.118937
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S075333222501131X
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules

1
1. scibot 15 Nov 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1021/acsomega.5c10222
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12612902/
www.biorxiv.org www.biorxiv.org

Identification of a First-In-Class Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry Screening

1
1. scibot 11 Nov 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1101/2025.11.05.686689
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

biorxiv.org/content/10.1101/2025.11.05.686689v1
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models

1
1. scibot 01 Oct 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.ejmech.2025.118194
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0223523425009596
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders

1
1. scibot 09 Aug 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.slasd.2025.100256
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2472555225000498
Jul 2025
www.biorxiv.org www.biorxiv.org

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules

1
1. scibot 12 Jul 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1101/2025.06.12.659248
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

biorxiv.org/content/10.1101/2025.06.12.659248v1
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High throughput screening assay for the identification of ATF4 and TFEB activating compounds

1
1. scibot 22 May 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1080/27694127.2025.2473765
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11980509/
Feb 2025
www.cell.com www.cell.com

Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies

1
1. scibot 13 Feb 2025
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.str.2025.01.019
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

cell.com/structure/fulltext/S0969-2126(25)00019-X
Aug 2024
www.sciencedirect.com www.sciencedirect.com

A new generation of nanobody research tools using improved mass spectrometry-based discovery methods

1
1. scibot 19 Aug 2024
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.jbc.2024.107623
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0021925824021240
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

1
1. scibot 10 May 2024
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.7554/eLife.89423
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11076045/
Feb 2024
www.biorxiv.org www.biorxiv.org

New submission 08/11/2023, 05:43:36

1
1. scibot 11 Feb 2024
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1101/2023.07.14.549041
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

biorxiv.org/content/10.1101/2023.07.14.549041v2
Oct 2023
www.biorxiv.org www.biorxiv.org

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies

1
1. scibot 27 Oct 2023
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1101/2023.10.22.563475
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

biorxiv.org/content/10.1101/2023.10.22.563475v1
Nov 2021
www.sciencedirect.com www.sciencedirect.com

An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance

1
1. scibot 24 Nov 2021
  
  in Public
  
  RRID:SCR_020985
  
  DOI: 10.1016/j.chembiol.2021.11.004
  
  Resource: Rockefeller University High Throughput Screening Resource Center Core Facility (RRID:SCR_020985)
  
  Curator: @scibot
  
  SciCrunch record: RRID:SCR_020985
  
  What is this?
  
  RRID:SCR_020985
Visit annotations in context

Tags

RRID:SCR_020985

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945621004815