94 Matching Annotations
  1. Sep 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A framework to mine laser microdissection-based omics data and uncover regulators of pancreatic cancer heterogeneity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12412123/
  3. link.springer.com link.springer.com
    Transcriptomic and microenvironment characteristics of triple-negative breast cancer under three different neoadjuvant treatment regimens
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    link.springer.com/article/10.1007/s10549-025-07810-7
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    Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
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    sciencedirect.com/science/article/pii/S2211124725009222
  5. Aug 2025
  6. www.sciencedirect.com www.sciencedirect.com
    Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer
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    sciencedirect.com/science/article/pii/S153561082500340X
  7. Jul 2025
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    Clinical and Transcriptomic Characterization of Metastatic Hormone-Sensitive Prostate Cancer Patients with Low PTEN Expression
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    mdpi.com/1422-0067/26/13/6244
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SpatialDeX is a Reference-Free Method for Cell Type Deconvolution of Spatial Transcriptomics Data in Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695180/
  10. www.biorxiv.org www.biorxiv.org
    Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma
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    biorxiv.org/content/10.1101/2025.06.21.660851v1
  11. Jun 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC12163602/
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    Piezo1 senses hyphae and initiates host defense against pathogenic fungi
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    sciencedirect.com/science/article/pii/S2211124725006102
  14. 52.53.155.43 52.53.155.43
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  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12129099/
  16. May 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clear-Cell Renal Cell Carcinoma Molecular Subtypes Differ by African and European Genetic Similarity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044083/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046331/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11534535/
  20. www.sciencedirect.com www.sciencedirect.com
    Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S1535610825001680
  21. Apr 2025
  22. aacrjournals.org aacrjournals.org
    Ancestral differences in anti-cancer treatment efficacy and their underlying genomic and molecular alterations
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    aacrjournals.org/cancerdiscovery/article/15/3/511/752115/Ancestral-Differences-in-Anticancer-Treatment
  23. aacrjournals.org aacrjournals.org
    Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities
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    aacrjournals.org/mcr/article/23/4/327/754237/Exploring-B7-H4-s-Role-in-Prostate-Cancer-Dormancy
  24. aacrjournals.org aacrjournals.org
    A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer
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    aacrjournals.org/clincancerres/article/31/8/1427/754531/A-Phase-II-Study-of-Abemaciclib-for-Patients-with
  25. aacrjournals.org aacrjournals.org
    The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite Stable Metastatic Colorectal Cancer: A Phase 1b/2a Trial
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    aacrjournals.org/clincancerres/article/31/4/649/751732/The-Prostaglandin-EP4-Antagonist-Vorbipiprant
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    KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation
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    sciencedirect.com/science/article/pii/S221112472500347X
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early Neutrophil Activation in Psoriatic Skin at Relapse Following Dead Sea Climatotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11969059/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962405/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962398/
  30. Mar 2025
  31. 52.53.155.43 52.53.155.43
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  32. Feb 2025
  33. 52.53.155.43 52.53.155.43
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  36. aacrjournals.org aacrjournals.org
    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    aacrjournals.org/clincancerres/article/30/22/5166/749574/Epigenome-Reprogramming-Through-H3K27-and-H3K4
  37. Jan 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11733536/
  39. 52.53.155.43 52.53.155.43
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  40. Dec 2024
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
  42. www.sciencedirect.com www.sciencedirect.com
    Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients
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    sciencedirect.com/science/article/pii/S1550413124004509
  43. Nov 2024
  44. 52.53.155.43 52.53.155.43
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  46. Sep 2024
  47. www.sciencedirect.com www.sciencedirect.com
    Exon Skipping-based Subtyping of Colorectal Cancers
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    sciencedirect.com/science/article/pii/S0016508524053575
  48. Aug 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350481/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in Glioblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10922678/
  51. Jul 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    sciencedirect.com/science/article/pii/S2666634024002484
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11290356/
  54. Jun 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer
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    sciencedirect.com/science/article/pii/S155041312400189X
  56. May 2024
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds
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    onlinelibrary.wiley.com/doi/10.1111/exd.15099
  58. aacrjournals.org aacrjournals.org
    Response rate and molecular correlates to encorafenib and binimetinib in BRAF-V600E mutant high-grade glioma
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    aacrjournals.org/clincancerres/article/30/10/2048/745176/Response-Rate-and-Molecular-Correlates-to
  59. www.sciencedirect.com www.sciencedirect.com
    T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells
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    sciencedirect.com/science/article/pii/S2211124724005862
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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    sciencedirect.com/science/article/pii/S1535610824001363
  61. www.sciencedirect.com www.sciencedirect.com
    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    sciencedirect.com/science/article/pii/S0092867424004483
  62. Apr 2024
  63. www.sciencedirect.com www.sciencedirect.com
    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    sciencedirect.com/science/article/pii/S2211124724004844
  64. www.sciencedirect.com www.sciencedirect.com
    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    sciencedirect.com/science/article/pii/S1535610824001193
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    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
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    sciencedirect.com/science/article/pii/S1534580724001886
  66. Mar 2024
  67. www.nature.com www.nature.com
    Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology
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    nature.com/articles/s41467-024-47027-8
  68. www.sciencedirect.com www.sciencedirect.com
    HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11
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    sciencedirect.com/science/article/pii/S0753332224003111
  69. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S155041312400055X
  70. Feb 2024
  71. www.sciencedirect.com www.sciencedirect.com
    Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The EstroGene database reveals diverse temporal, context-dependent, and bidirectional estrogen receptor regulomes in breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527051/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866549/
  74. Jan 2024
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10330305/
  76. Dec 2023
  77. www.sciencedirect.com www.sciencedirect.com
    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection
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    sciencedirect.com/science/article/pii/S2589004223026494
  78. www.sciencedirect.com www.sciencedirect.com
    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S1535610823004014
  79. Nov 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-prone Phenotypes and Gene Expression Heterogeneity at Single-cell Resolution in Cigarette-smoking Lungs
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    ncbi.nlm.nih.gov/pmc/articles/PMC10637260/
  81. dx.doi.org dx.doi.org
    Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
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    dx.doi.org/10.1158/2767-9764.CRC-23-0165
  82. Oct 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections
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    ncbi.nlm.nih.gov/pmc/articles/PMC10580374/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10551667/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10543973/
  86. Aug 2023
  87. dx.doi.org dx.doi.org
    Integrative single-cell and bulk transcriptomes analyses identify intrinsic HNSCC subtypes with distinct prognoses and therapeutic vulnerabilities
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    dx.doi.org/10.1158/1078-0432.CCR-22-3563
  88. Jul 2023
  89. www.sciencedirect.com www.sciencedirect.com
    Temporal transcriptome features identify early skeletal commitment during human epiphysis development at single-cell resolution
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    sciencedirect.com/science/article/pii/S2589004223012774
  90. www.sciencedirect.com www.sciencedirect.com
    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    sciencedirect.com/science/article/pii/S2589004223011720
  91. Jun 2023
  92. 52.53.155.43 52.53.155.43
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    Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion
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    ncbi.nlm.nih.gov/pmc/articles/PMC10240575/
  95. May 2023
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10150241/
  97. Apr 2023
  98. aacrjournals.org aacrjournals.org
    Multi-substrate metabolic tracing reveals marked heterogeneity and dependency on fatty acid metabolism in human prostate cancer
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    aacrjournals.org/mcr/article/21/4/359/718952/Multi-substrate-Metabolic-Tracing-Reveals-Marked
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10108886/
  100. Mar 2023
  101. link.springer.com link.springer.com
    Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers
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    link.springer.com/article/10.1186/s13100-023-00290-w
  102. Feb 2023
  103. aacrjournals.org aacrjournals.org
    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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    aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
  104. Nov 2022
  105. www.sciencedirect.com www.sciencedirect.com
    Systematic single-cell pathway analysis to characterize early T cell activation
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    sciencedirect.com/science/article/pii/S2211124722015716
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9674345/
  107. www.sciencedirect.com www.sciencedirect.com
    CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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    sciencedirect.com/science/article/pii/S2211124722015108
  108. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
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    sciencedirect.com/science/article/pii/S1535610822005037
  109. Oct 2022
  110. www.sciencedirect.com www.sciencedirect.com
    Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting
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    sciencedirect.com/science/article/pii/S2211124722014036
  111. Sep 2022
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biological misinterpretation of transcriptional signatures in tumor samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data
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    ncbi.nlm.nih.gov/pmc/articles/PMC9475248/
  113. www.sciencedirect.com www.sciencedirect.com
    A small proportion of X-linked genes contribute to X chromosome upregulation in early embryos via BRD4-mediated transcriptional activation
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    sciencedirect.com/science/article/pii/S0960982222013811
  114. Jul 2022
  115. link.springer.com link.springer.com
    Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys
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    link.springer.com/article/10.1007/s12079-022-00685-z
  116. Jan 2022
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8687658/
  118. Nov 2021
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    Multi-tumor analysis of cancer-stroma interactomes of patient-derived xenografts unveils the unique homeostatic process in renal cell carcinomas
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    sciencedirect.com/science/article/pii/S2589004221012918
  120. Aug 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers
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    sciencedirect.com/science/article/pii/S2666379121001981
  122. Jul 2021
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    Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
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    sciencedirect.com/science/article/pii/S1534580721005281
  124. May 2021
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    Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression
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    sciencedirect.com/science/article/pii/S1934590921001879