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  1. Mar 2019
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. - PubMed - NCBI
    1
    1. Drugs_and_Ethics 16 Mar 2019
      We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice.

      H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.

      H2 histamine receptor H1 histamine receptor antihistamine opioid histamine knockout gene analgesia mouse study drug combination agonist antagonist
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    ncbi.nlm.nih.gov/pubmed/16806305
  3. Aug 2018
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Clonidine effects on all‐night human sleep: Opposite action of low‐ and medium‐dose clonidine on human NREM–REM sleep proportion
    1
    1. Drugs_and_Ethics 30 Aug 2018
      25 µg

      Apparently, clonidine is active at one quarter of the starting dose. Namely, it is active at 25 micrograms (mcg) compared to the 100mcg starting dose.

      clonidine alpha-2 agonist
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    onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1819.2003.01207.x