2 Matching Annotations
  1. Oct 2017
    1. high cytotoxic potency is linked to CD8+ effector memory T (TEM) and CD45RA+ TEM (TEMRA) cells, and to CD4+ TEM and central memory T (TCM)-cells due to their large number of preformed perforin and granzyme B-filled vesicles and their great proliferative capacity. Another notable T-cell subset in the context of immunotherapy are CD4+ regulatory T (TREG) cells. Their presence in the tumor microenvironment is implicated in the suppression of naturally occurring anti-tumor T-cell responses

      potent t cells for bite highly cytotoxic moa

    1. The absence of a need for co-signaling through CD28 for these BiTEs might also be explained by the observation that among all T cell subtypes, CD8+ effector memory cells CD45RO+ (TEM) and CD8+ effector memory CD45RA+ (TEMRA) contribute the most to BiTE activity, whereas naïve T cells do not contribute at all to the killing efficiency.50 It is believed that memory T cells do not require CD28 costimulation for expansion during secondary responses, which could explain the efficiency of BiTEs. However, this dogma has recently been challenged.5

      absence of need for cosignal effector memory cells contribute most to bite activity memory T ells dont require cd28 costimulation for expansion?