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  1. Oct 2023
    1. Cell-Free DNA

      Non invasive prenatal testing

      If positive amniotic testing and chorionic villi sampling are indicated one after 10 weeks -Contraindicated in twins

      Useless for neural tube defect

    2. INVASIVE PROCEDURES

      Complications: Cramping, Bleeding or leaking of amniotic fluid, injury or infection, loss of pregnancy, premature labor, alloimmunization

    3. Chorionic Villus

      Must be fetal part of the Placenta

      Indications: -Positive Combined Test in first trimester -Positive triple and quadruple trimester in second trimester (do amniocentesis) -If sibling has previous chromosomal disorders -In older females

    4. Nuchal Translucency

      Used to rule out risk for aneuploidy and cardiac disease

      45-84 Cm (10 to 14 weeks) -Head must be in full view, and fetus in neutral position -Mid sagittal view, widest diameter

      Useless for neural tube defects

    5. obstetrical ultrasound.

      CRL in the first trimester From the crown (Highest point) to the Rump (Lowest Point)

      BPD in the second trimester (Biparietal Diameter: Between the two parietal bones) The aforementioned are in the ??? view

      Head circumference (HC) Abdominal Circumference (AC): Requires 2 ribs in the view and other things Femur Length (FL): View from diaphysis to diaphysis

    6. Pregnancy bleeding

      Differential: Local or External OR Pregnancy Related -Cervical Ectopia, Lacertion, Lost Pregnancy Cervical Ectopia is IMPORTNAT (INTRA VS EXTRA Uterine) Viability of Fetus

      Prior to PV we need to do US to rule out Placenta Privea if there is vaginal bleeding

    7. Naegele’s rule: Assuming 28-day cycles, a due date can be estimated as the LMPminus 3 months + 7 days

      Example: Menses 20/7/2023 Thus: 20+7/7-3/2024 =27/4/2024

      Accuracy depends on duration of Menses

    8. Ultrasound

      Some thing are visible at different ages

      Heart at 6 week Yolk sac 5 weeks and 4 days

      Crown Rump length - Weeks per Cms

      Booking visit: Determine gestational age Early on the US datings are the most accurate -Later on, aging gets less acccurate

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