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    1. The ligand binding sites are situated at the interface betweentwo neighboring subunits, the principal (ie, two constantα-subunits) and the complementary non-α subunits (Figure6A)

      This is about the ligand binding site

    2. Amajor step toward this achievement was the determination ofthe high-resolution crystal structures of the soluble proteinsthat bind ACh or serotonin, AChBP and 5-HTBP

      these proteins bind Acetylcholine