2 Matching Annotations
  1. Sep 2023
  2. link-springer-com.proxy.lib.utc.edu link-springer-com.proxy.lib.utc.edu
    Concussion Pathophysiology and Injury Biomechanics
    2
    1. erinlunt 25 Sep 2023
      Despite the lack of structural changes seen on standard neuroimaging, advances in neuroimaging techniques have helped to identify short and long-term region-specific morphologic changes.

      The article has previously stated that human research on the brain post concussion and other head injuries is limited. However, advancements in neuroimaging have helped identify structural changes following injury. I wonder as these advancements become more readily available to the public if the way we prevent, diagnose, and treat concussions will evolve?

    2. erinlunt 25 Sep 2023
      Furthermore, repeat mTBI rat models showed an increased neuronal loss in the hippocampus 28 days post-injury with attenuated NMDA receptor-mediated responses and impaired LTP [73]. More recent studies suggest that environmental enrichment strategies improved memory, decreased anxiety, and promoted exploratory behavior after repeated mTBI, possibly by mitigating post-injury NMDA subunit synaptic changes [74].

      Neuron loss in the hippocampus approximately 4 weeks following a brain injury is not something I would have previously considered. It is promising to know however, as a future clinician that rodents who experienced mTBI's but received environmental enrichment saw improvement despite the neuronal loss.

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    link-springer-com.proxy.lib.utc.edu/article/10.1007/s12178-019-09536-8