9 Matching Annotations
  1. May 2022
  2. www-ncbi-nlm-nih-gov.proxy-bloomu.klnpa.org www-ncbi-nlm-nih-gov.proxy-bloomu.klnpa.org
    1. ICER1 gen


    2. DICER1 syndrome


    3. disrupts the biogenesis and processing of miRNAs with subsequent disruption in control of gene

      effects miRNA

    4. ers included, comparedto the control population: 8% and 0% for women and men, respectively [ 23 ]. Specifically, a recent studyindicated a correlation between truncating germline DICER1 mutations and familial multinodulargoiter, among other cancers [24]. Women are more likely to develop thyroid cancer than men, regardlessof DICER1 variant status [25 ]. Frequent malignant neoplasms of the endocrine system [26 ] such as

      family history

    5. Another study confirmed this, indicating that more than 60% of ovarianSertoli–Leydig cell tumors diagnosed harbored DICER1 mutations within the RNase III domain

      the same mutation

    6. History: Sertoli–Leydig cell tumor.

      the case study I referenced in the paper

    7. e mutation was found to be heterozygous forgermline but hemizygous in the tumor itself


    8. tumorigenesi

      second mutation

    9. , located on chromosome 14, position q32.1