- Jun 2017
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sites.google.com sites.google.com
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endocytosis
Both Dengue virus and Coxsackievirus A16 enter the host cell via endocytosis rather than membrane fusion.
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positive sense RNA
Both Dengue virus and Coxsackievirus A16 have positive sense RNA.
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sites.google.com sites.google.com
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positive-sense RNA genome
Both Dengue virus and Coxsackievirus A16 have positive sense RNA.
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endocytosis
Both Dengue virus and Coxsackievirus A16 enter the host cell via endocytosis.
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- May 2017
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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. S. pneumoniae was the most common cause of bacterial meningitis (58.0%), followed by Streptococcus agalactiae (group B streptococcus) (18.1%), N. meningitidis (13.9%), H. influenzae (6.7%), and Listeria monocytogenes (3.4%).
prevalence
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Annotators
URL
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Streptococcus pneumoniae Group B Streptococcus Neisseria meningitidis Haemophilus influenzae Listeria monocytogenes
bacteria that cause it
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Annotators
URL
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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certain virulence factors (hemolysis and adhesion).
virulence factors
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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resistance to penicillin.
resistance
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Most Shewanella spp. isolates are susceptible to cefotaxime (95%), piperacillin and tazobactam (98%), gentamicin (99%), and ciprofloxacin (94%).
antibiotic susceptibility
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ear infection, or abdominal and biliary tract infections.
symptoms
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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β-lactamase antibiotics
antibiotic
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treated easily by a combination of surgical therapy, drainage and antibiotics.
treatment
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Thus we tried to find out as to how many of Shewanella spp. are wrongly reported as Pseudomonas spp. by just doing simple biochemical tests over a period of six months.
how to distinguish between shewanella and pseudomonas
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soil and water being their natural habitat
where organism found
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oxidase and catalase-positive non-fermenter gram-negative rod that produces hydrogen sulfide.
tests
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foods, sewage, and both from fresh and salt water.
where organism found
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en.wikipedia.org en.wikipedia.org
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hydrogen sulfide on TSI.[
TSI slant
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On blood agar plates, the colonies are typically convex and large, with a brown pigment, and cause “greening” of the agar around the colonies.
blood agar
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bright pink color. On solid media, the colonies are round, fast-growing, and pink.
growing conditions
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facultative anaerobe
oxygen
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marine environments
where organism is found
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www.who.int www.who.intE. coli1
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The incubation period can range from 3 to 8 days
incubation period
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www.cdc.gov www.cdc.gov
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Multistate Outbreak of Shiga toxin-producing Escherichia coli O157:H7 Infections Linked to I.M. Healthy Brand SoyNut Butter (Final Update)
recent outbreak
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www.thieme-connect.com www.thieme-connect.com
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Stxs cross the intestinal barrier and bind to endothelial cells. At this point they presumably injure the host cell by inhibition of protein synthesis, stimulation of prothrombotic messages, or induction of apoptosis.
stx (virulence factor)
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www.frontiersin.org www.frontiersin.org
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Cattle are a major reservoir
usually found in cattle
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In anepidemiology study conducted by the Centers for Disease Controland Prevention, patients treated with antibiotics for EHEC enteri-tis had a higher risk of developing HUS
those with antibiotics are more likely to get HUS
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Currently no treatment is available for EHEC infections
no treatment
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75% of EHEC outbreaks are linked to the consumption of contaminatedbovine-derived products
outbreak prevalence
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outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS)worldwide
symptoms
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academic.oup.com academic.oup.com
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30-day mortality rate was 39%
mortality rate
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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20 to 35%
resistance rate
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emedicine.medscape.com emedicine.medscape.com
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combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, meropenem) with antipseudomonal quinolones may be used in conjunction with an aminoglycoside.
treatment
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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virulence factors
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www.news-medical.net www.news-medical.net
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Streptococcal bacteria use an enzyme called streptokinase to block the blood clotting response and allow themselves to move more freely around the human host's circulatory system.
streptokinase description
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en.wikipedia.org en.wikipedia.org
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M protein
description of what M protein does in strep
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nfsuk.org.uk nfsuk.org.uk
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Although deep infections can easily be treated with antibiotics, we know that some people can die from this type of infection, especially when the bacteria have spread into the bloodstream (bacteremia).
treated with antibiotics unless bacteria has reached blood
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Severe Acute Pharyngitis Caused by Group C Streptococcus
can result in severe acute pharyngiitis
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- Apr 2017
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rarediseases.org rarediseases.org
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Group A Streptococci
Most common cause of NF
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journal.frontiersin.org journal.frontiersin.org
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Enterococcus faecium
This can live within the intestine and not have harmful effects, but it can also be dangerous and lead to neonatal meningitis or endocarditis. https://en.wikipedia.org/wiki/Enterococcus_faecium
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www.asp.mednet.ucla.edu www.asp.mednet.ucla.edu
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Significance of organism is determined by colony count.
colony count from urine sample can determine the bacteria
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Group B Strep
aerobic and in pairs/chains
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emedicine.medscape.com emedicine.medscape.com
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Penicillin G
antibiotic
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Lab tests
biochemical tests?
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Table 13-3
biochemical tests
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www.cdc.gov www.cdc.gov
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These skin infections may also be accompanied by a fever
fever
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Red Swollen or painful Warm to the touch Full of pus or other drainage
similar to the case
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www.cdc.gov www.cdc.gov
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Streptomycin
Drug used to treat tularemia
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Gentamicin
Another drug to use, but not as successful as streptomycin
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www.cdc.gov www.cdc.gov
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Tularemia is more common in the months of May through September. Bites from infected ticks or deer flies usually occur in the summer months, but illness due to animal handling and hunting can occur at any time of the year
More cases in summer when people are more likely to be outside farming, cutting hay, working outdoors, etc.
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www.cdc.gov www.cdc.gov
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Signs & Symptoms
Signs and Symptoms of Tularemia
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www.cdc.gov www.cdc.gov
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antibiotics
treatment
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Skin contact with infected animals
Ask "Have you been around any animals in nature, a zoo, etc.?"
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Tick and deer fly bites Skin contact with infected animals Ingestion of contaminated water Inhalation of contaminated aerosols or agricultural dusts Laboratory exposure
Mode of transmission
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Francisella tularensis
The bacteria that causes Tularemia
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Annotators
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www.medicinenet.com www.medicinenet.com
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causing major organs to fail. Pneumonia is common after inhalation but may also occur when the organism spreads throughout the body.
symptoms and future cause
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fever, fatigue, aches and headache. Swollen lymph nodes
look for these symptoms in patient
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Tularemia may be spread through inhalation of dried animal matter, eating undercooked game, skinning or dressing killed animals, or drinking water contaminated with animal carcasses.
Ask if they have eaten wild game or hunted wild game recently.
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