Three (3)patients received a total skin graft. The sample wastaken from the anterior side of the wrist in 2 cases.

The operated area is covered with fat and wetdressing. In any case, dry dressing is never optedfor. T

The omegaflap is marked on the dorsal surface of the finger.Its base corresponds to the metacarpal heads andits vertex reaches the proximal interphalangealjoint level. On the palmar surface, incisions aremade to form an anchor that starts at

e proximalinterphalangeal joint and descends few millimetersbelow the level of the desired web.

commissural dorsal omega flap, with or withoutskin graft were all included in the study.

The aim of this work is to report the different typesof congenital syndactylies and the most frequentsyndromic forms, the application of commissural

If a cell in the test dataset is confidently assigned to a particular label, we would expect it to have strong expression of that label’s markers

red.grun)

ing log-normalized expressio

discusssed here and in Section 2.3.

pairwise Wilcoxon rank sum tests

sum(width(mm.exons)

mart-seq2 test datasets against the celldex references

actual.hsc <- pred$labels[sce$protocol=="sorted hematopoietic stem cells" & sce$sample!="JC4"] head(sort(table(actual.hsc), decreasing=TRUE))

f we restrict our analysis to the sorted HSCs (obviously) and remove one low-quality batch (see the analysis here for the rationale) we can see that the

Markers

ng a lower resolution threshold

patchwork characteristics

ouvain-based cluster analysis

lly aligned

equence to depths

onocle 3

l CytoTRACE

50 most highly ranked genes from this analysis for each cluster were usedto perform gene set enrichment analysis in a programmatic fashion using EnrichR

predictive power to each gene

on (UMAP) analysis over the first 15 principal components

UMI counts w

emia tim

cDNA library concentrations were 858.7 and 364.7 pg/μL

incurfinancial catastrophe as a result of seeking care

We looked at three primary outcomes ofaccessing surgical and anaesthesia care: the annualnumber of cases of catastrophic expenditure from OOPmedical costs, the annual number of cases of catastrophicexpenditure from OOP non-medical costs, and thenumber of people at risk of catastrophic expenditureshould they need surgical and anaesthesia care. Fullmethods can be found in the accompanying paper.2

Med

26.

ich factors limit the patient’s accessto surgical care? (Select all that appl

9.

id the mother smokeduring pregnancy? ` `16. Was the mother exposed tosecondhan

o limit our re-view to simple and complex syndactyly and excludedcomplicated cases.

ds straight lines to reduce the potentialfor contracture or deviation.

does notsupport recommendations in favour of any particularsurgical technique

) Reoperation was a commonmarker (21 papers) of web creep recurrence in this lit-erature series. However, the clinical criteria on which theindication for further surgery was based were not alwaysclearly described. Two different approaches to the as-sessment of web creep included x-ray monitoring by Ve-kris et al.49) and clinical photography by Niranjan et al.2

CIBERSORTx

feature extraction algorithm (24)

patial multiomics,combining spatial transcriptomics with paired scRNA-seq andscATAC-seq datasets

single-cell RNA and ATAC sequencing (scRNA-seq andscATAC-seq)

repairkinetics and multiple Rainbow transgenic lines t

. Repeating these experiments using porcine cells and scRNA-seq

fate probability estimates with a pseudotemporalordering along latent tim

transcriptionally distinct cell lineage

information with transcriptomic similarity tocompute a global map of cellular fate potentials uncovering initialand terminal cell states

RNA velocityanalysis using scVelo and CellRank

Genetrail3, a

posi-tional cloning

conditionalknockout techniques

ELEX-Seq

in situhybridization for Esrp1 (F

Comparison of the predicted ΔPSI as measured by rMATS and theΔPSI determined by semi quantitative RT-PCR revealed a high correlation between these twomeasurements in WT and DKO samples

We generated over 560 million paired sequencing reads in total from 2–3 biologicalreplicates from each genetic group which uniquely mapped to over 440 million mapped pairs. Eachgenetic group was represented by at least 70 million unique paired sequencing reads mapped to themouse mm10 genome at ∼70–85% mapping rate

rand-specific polyA-selected mRNA sequencing libraries and the multiplexed libraries were sequencedtogether on a single flow cell across 2 lanes with an Illumina HiSeq 2000 (

ariable functional redundancy

Alizarin Red and Alcian Blue bone and cartilage stains

We confirmed the expected Mendelian transmission rates of the Esrp1 and Esrp2KO alleles in these crosses, indicating there was no early embryonic lethality associated with loss of theEsrps

Knockout Mouse Project (KOMP)

splicing sensitive microarrays

d Esrp2