Right upper panel shows genes related to the IRE1α and ATF6 pathways

genes from cluster 4 whose expression is specifically upregulated in Pre-PB and PB stages are mainly associated with IRE1α - and ATF6- mediated UPR

An excellent example of this is age-related clonal haematopoiesis (ARCH)66. In more than 10% of adults aged 60 years or older, steady-state haematopoiesis (more than 5 × 1011 blood cells are generated each day) occurs from a restricted number of clonal haematopoietic stem cells and progenitor cells that harbour somatic mutations that confer a clonal advantage. Strikingly, ARCH is associated with an increased risk of a subsequent haematological malignancy and with an almost twofold increased risk of cardiovascular death

Although it is clear that histone modifications robustly modulate key nuclear processes and there is strong evidence for the role of histone methylation in DNA-related processes, as outlined above, it is difficult to experimentally prove a direct causative role of any histone modification in mammalian cells

Important clues to the functions of particular DNA, RNA or histone methylation marks can be gained from knowledge of their cellular and intramolecular localizations. Thus, much effort has been expended in mapping the modified sites using various biochemical techniques (for example, chromatin immunoprecipitation assays) and biophysical techniques (for example, mass spectrometry), which together have provided detailed genomic and transcriptomic methylation profiles.

the identification of specific demethylases (Fig. 1; Supplementary Fig. 1) has revealed that methylation is a dynamic process, which is consistent with its important regulatory roles19. As we discuss below, this dynamic nature provided the rationale for therapeutic intervention

We found significant inhibition of PC generation if anti-CD40 Ab was washed out 24 h after culture initiation

iable PCs (CD138 ++/40,6-diami-dine-2-phenylindole dihydrochloride negative [DAPI])

thrombotic thrombocytopenic purpura

Plasma cells in systemic lupus erythematosus: The long and short of it all

B cells regulate autoimmunity by provision of IL-10

Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation

Cells

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

The CRISPR tool kit for genome editing and beyond

RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulator

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