If you create or post one, remember to pay attention to the source of the image. Your best bet is to start with an image or clip that is already labeled for reuse or is in the public domain, meaning out of copyright protection altogether. Google Images search tools provides such a filter, or try the Creative Commons search for work licensed for reuse via Creative Commons licenses.
Even if not creating or posting a meme, this is very good info to know for checking sources for using images. I'll be paying much closer attention.