499 Matching Annotations
  1. Dec 2022
  2. www.science.org www.science.org
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
    1
    1. scibot 13 Dec 2022
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      DOI: 10.1126/sciadv.abq0648

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    science.org/doi/10.1126/sciadv.abq0648
  3. Nov 2022
  4. www.sciencedirect.com www.sciencedirect.com
    Autophagy promotes cell survival by maintaining NAD levels
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    1. scibot 22 Nov 2022
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      DOI: 10.1016/j.devcel.2022.10.008

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    sciencedirect.com/science/article/pii/S1534580722007602
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
    1
    1. scibot 18 Nov 2022
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      DOI: 10.1016/j.molcel.2022.09.013

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    sciencedirect.com/science/article/pii/S1097276522009029
  6. academic.oup.com academic.oup.com
    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
    1
    1. scibot 15 Nov 2022
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      DOI: 10.1093/narcan/zcac036

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    academic.oup.com/narcancer/article/4/4/zcac036/6825304
  7. www.sciencedirect.com www.sciencedirect.com
    Enhanced DNA repair through droplet formation and p53 oscillations
    1
    1. scibot 11 Nov 2022
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      DOI: 10.1016/j.cell.2022.10.004

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    sciencedirect.com/science/article/pii/S0092867422013198
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    The phenotypic landscape of essential human genes
    1
    1. scibot 08 Nov 2022
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      DOI: 10.1016/j.cell.2022.10.017

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    sciencedirect.com/science/article/pii/S0092867422013599
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    Metabolic regulation by p53 prevents R-loop-associated genomic instability
    1
    1. scibot 03 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111568

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    sciencedirect.com/science/article/pii/S2211124722014292
  10. Oct 2022
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain
    1
    1. scibot 27 Oct 2022
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      DOI: 10.1002/glia.24282

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    onlinelibrary.wiley.com/doi/10.1002/glia.24282
  12. www.sciencedirect.com www.sciencedirect.com
    DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111526

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    sciencedirect.com/science/article/pii/S2211124722013821
  13. www.sciencedirect.com www.sciencedirect.com
    Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
    1
    1. scibot 20 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111501

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    sciencedirect.com/science/article/pii/S2211124722013511
  14. www.sciencedirect.com www.sciencedirect.com
    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
    1
    1. scibot 12 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111475

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    sciencedirect.com/science/article/pii/S2211124722013250
  15. www.nature.com www.nature.com
    C9orf72 functions in the nucleus to regulate DNA damage repair
    1
    1. scibot 12 Oct 2022
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      DOI: 10.1038/s41418-022-01074-0

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    nature.com/articles/s41418-022-01074-0
  16. pubs.acs.org pubs.acs.org
    Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen
    1
    1. scibot 08 Oct 2022
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      DOI: 10.1021/acsptsci.2c00147

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    pubs.acs.org/doi/full/10.1021/acsptsci.2c00147
  17. www.sciencedirect.com www.sciencedirect.com
    Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.molcel.2022.09.012

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    sciencedirect.com/science/article/pii/S1097276522009017
  18. www.sciencedirect.com www.sciencedirect.com
    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.chembiol.2022.09.002

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    sciencedirect.com/science/article/pii/S2451945622003506
  19. Sep 2022
  20. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    1
    1. scibot 29 Sep 2022
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      DOI: 10.15252/embr.202154136

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    embopress.org/doi/10.15252/embr.202154136
  21. www.sciencedirect.com www.sciencedirect.com
    Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
    1
    1. scibot 21 Sep 2022
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    sciencedirect.com/science/article/pii/S2211124722012074
  22. www.sciencedirect.com www.sciencedirect.com
    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111329

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    sciencedirect.com/science/article/pii/S2211124722011573
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
    1
    1. scibot 02 Sep 2022
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      DOI: 10.1158/0008-5472.CAN-21-1843

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
  24. Aug 2022
  25. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
    1
    1. scibot 30 Aug 2022
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      DOI: 10.1016/j.isci.2022.104944

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    sciencedirect.com/science/article/pii/S2589004222012160
  26. www.sciencedirect.com www.sciencedirect.com
    RAD51 protects human cells from transcription-replication conflicts
    1
    1. scibot 26 Aug 2022
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      DOI: 10.1016/j.molcel.2022.07.010

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    sciencedirect.com/science/article/pii/S1097276522007067
  27. www.sciencedirect.com www.sciencedirect.com
    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
    1
    1. scibot 22 Aug 2022
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      DOI: 10.1016/j.ccell.2022.07.012

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    sciencedirect.com/science/article/pii/S1535610822003257
  28. Jul 2022
  29. aacrjournals.org aacrjournals.org
    Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer
    1
    1. scibot 31 Jul 2022
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      DOI: 10.1158/2767-9764.CRC-21-0139

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    aacrjournals.org/cancerrescommun/article/2/7/706/707154/Potent-Stimulation-of-the-Androgen-Receptor
  30. www.sciencedirect.com www.sciencedirect.com
    Guiding ATR and PARP inhibitor combinationswith chemogenomic screens
    1
    1. scibot 13 Jul 2022
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      DOI: 10.1016/j.celrep.2022.111081

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    sciencedirect.com/science/article/pii/S2211124722008798
  31. academic.oup.com academic.oup.com
    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    1. scibot 13 Jul 2022
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      DOI: 10.1093/nar/gkac591

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac591/6640223
  32. www.nature.com www.nature.com
    Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy
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    1. scibot 01 Jul 2022
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      DOI: 10.1038/s41418-022-01036-6

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    nature.com/articles/s41418-022-01036-6
  33. Jun 2022
  34. 52.53.155.43 52.53.155.43
    mct-21-0798-html.html
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    1. scibot 30 Jun 2022
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      DOI: 10.1158/1535-7163.mct-21-0798

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    2. scibot 24 Jun 2022
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      DOI: 10.1158/1535-7163.MCT-21-0798

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    52.53.155.43/9002f710d59c7dcb5dd8d70237b19dc81be5139d/mct-21-0798 (1)-html.html
  35. www.sciencedirect.com www.sciencedirect.com
    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
    1
    1. scibot 30 Jun 2022
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      DOI: 10.1016/j.devcel.2022.06.003

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    sciencedirect.com/science/article/pii/S1534580722004129
  36. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
    1
    1. scibot 17 Jun 2022
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      DOI: 10.1016/j.isci.2022.104519

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    sciencedirect.com/science/article/pii/S2589004222007908
  37. www.sciencedirect.com www.sciencedirect.com
    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
    1
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      DOI: 10.1016/j.celrep.2022.110940

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    sciencedirect.com/science/article/pii/S2211124722007227
  38. www.sciencedirect.com www.sciencedirect.com
    Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD
    1
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      DOI: 10.1016/j.celrep.2022.110913

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    sciencedirect.com/science/article/pii/S2211124722006908
  39. www.sciencedirect.com www.sciencedirect.com
    Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
    1
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      DOI: 10.1016/j.biopha.2022.113230

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    sciencedirect.com/science/article/pii/S0753332222006199
  40. May 2022
  41. www.sciencedirect.com www.sciencedirect.com
    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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      DOI: 10.1016/j.isci.2022.104398

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    sciencedirect.com/science/article/pii/S2589004222006691
  42. www.sciencedirect.com www.sciencedirect.com
    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    sciencedirect.com/science/article/pii/S153458072200332X
  43. www.sciencedirect.com www.sciencedirect.com
    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
    1
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      DOI: 10.1016/j.molcel.2022.04.031

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    sciencedirect.com/science/article/pii/S109727652200394X
  44. www.sciencedirect.com www.sciencedirect.com
    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
  45. www.sciencedirect.com www.sciencedirect.com
    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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    1. scibot 19 May 2022
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      DOI: 10.1016/j.isci.2022.104354

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    sciencedirect.com/science/article/pii/S2589004222006253
  46. Apr 2022
  47. www.nature.com www.nature.com
    Sister chromatid–sensitive Hi-C to map the conformation of replicated genomes
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      DOI: 10.1038/s41596-022-00687-6

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    nature.com/articles/s41596-022-00687-6
  48. www.sciencedirect.com www.sciencedirect.com
    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    1. scibot 21 Apr 2022
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    sciencedirect.com/science/article/pii/S1097276522002684
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    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
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    Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
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    MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
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    The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies
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    ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression
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    Force-generating apoptotic cells orchestrate avian neural tube bending
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    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis
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      Mouse Anti-phospho Histone H2A.X (Ser139) conjugated with Alexa Fluor 647

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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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  134. May 2021
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
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    TMPRSS11a is a novel age‐altered, tissue specific regulator of migration and wound healing
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  148. Apr 2021
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    p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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    Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells
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    A Genetic Map of the Response to DNA Damage in Human Cells
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      Mouse monoclonal anti-γH2AX

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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
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    Influence of the microenvironment on modulation of the host response by typhoid toxin
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  156. www.sciencedirect.com www.sciencedirect.com
    SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
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      H2AX

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  157. Mar 2021
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    TRPS1 drives heterochromatic origin refiring and cancer genome evolution
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    Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions
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    The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks
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    A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
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    ER-directed TREX1 limits cGAS activation at micronuclei
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  165. Feb 2021
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    A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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  170. Jan 2021
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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    The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis
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    MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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  176. Dec 2020
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
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    Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
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  181. Nov 2020
  182. royalsocietypublishing.org royalsocietypublishing.org
    Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture
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      DOI: 10.1098/rsob.200200

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    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
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    The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells
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      Anti-γH2AX

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
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      DOI: 10.7554/eLife.57117

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  186. Oct 2020
  187. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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  188. Sep 2020
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    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
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    Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
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    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
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    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
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    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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    PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability
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    ATR expands embryonic stem cell fate potential in response to replication stress
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    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
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    Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12
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    cell.com/cell-reports/fulltext/S2211-1247(18)31406-2
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    MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis
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      mouse anti-phospho-Histone H2A.X

      DOI: 10.1093/nar/gkaa406

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    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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      γH2AX

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    Zygotic Nuclear F-Actin Safeguards Embryonic Development
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  214. www.nature.com www.nature.com
    N 6 -methyladenosine regulates the stability of RNA:DNA hybrids in human cells
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      anti-γH2AX mouse monoclonal

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  215. academic.oup.com academic.oup.com
    Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
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      γ-H2AX

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  216. elifesciences.org elifesciences.org
    Parvovirus Minute Virus of Mice Interacts with Sites of Cellular DNA Damage to Establish and Amplify its Lytic Infection
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      γ−Η2ΑX

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    Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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  219. Jan 2020
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    CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
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  221. www.eneuro.org www.eneuro.org
    Homeoprotein Neuroprotection of Embryonic Neuronal Cells
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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    sciencedirect.com/science/article/pii/S1097276519305489
  227. www.sciencedirect.com www.sciencedirect.com
    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
    1
    1. scibot 13 Jan 2020
      RRID:AB_309864

      DOI: 10.1016/j.molcel.2019.06.043

      Resource: (Millipore Cat# 05-636, RRID:AB_309864)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_309864

      What is this?

      RRID:AB_309864 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276519305003