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Jul 2025
www.sciencedirect.com www.sciencedirect.com

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

1
1. scibot 15 Jul 2025
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.ccell.2025.06.011
  
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sciencedirect.com/science/article/pii/S1535610825002612
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

1
1. scibot 16 Apr 2025
  
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  RRID:AB_210547
  
  DOI: 10.1126/sciadv.adq2519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980859/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

1
1. scibot 05 Apr 2025
  
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  RRID:AB_210547
  
  DOI: 10.3389/fonc.2025.1554059
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11967197/
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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

1
1. scibot 01 Apr 2025
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2025.115452
  
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sciencedirect.com/science/article/pii/S2211124725002232
Mar 2025
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Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers

1
1. scibot 25 Mar 2025
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.canlet.2025.217665
  
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sciencedirect.com/science/article/pii/S0304383525002319
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy

1
1. scibot 20 Mar 2025
  
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  RRID:AB_210547
  
  DOI: 10.1038/s41598-025-92697-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11906863/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

1
1. scibot 29 Jan 2025
  
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  RRID:AB_210547
  
  DOI: 10.3390/biom15010150
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

1
1. scibot 27 Dec 2024
  
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  AB_210547
  
  DOI: 10.1016/j.neo.2024.101092
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

1
1. scibot 21 Dec 2024
  
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  RRID:AB_210547
  
  DOI: 10.1101/2024.12.01.626256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11642733/
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

1
1. scibot 21 Dec 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.molcel.2024.11.034
  
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sciencedirect.com/science/article/pii/S1097276524009894
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

1
1. scibot 21 Dec 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
Nov 2024
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Profound synthetic lethality between SMARCAL1 and FANCM

1
1. scibot 17 Nov 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.molcel.2024.10.016
  
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sciencedirect.com/science/article/pii/S1097276524008566
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Acute multi-level response to defective de novo chromatin assembly in S-phase

1
1. scibot 14 Nov 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.molcel.2024.10.023
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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sciencedirect.com/science/article/pii/S1097276524008633
Sep 2024
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ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

1
1. scibot 25 Sep 2024
  
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  RRID:AB_309864
  
  DOI: 10.1016/j.celrep.2018.08.019
  
  Resource: (Millipore Cat# 05-636, RRID:AB_309864)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_309864
  
  Curator comments: Bethyl Cat# A300-245A, Phospho RPA32 (S4/S8) Antibody
  
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  RRID:AB_309864 RRIDCUR:Incorrect RRID:AB_210547
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sciencedirect.com/science/article/pii/S2211124718312737
Jul 2024
52.53.155.43 52.53.155.43

PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html

1
1. scibot 23 Jul 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2019.01.013
  
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52.53.155.43/dff7bc1da9f5df512f47678d2bc141ea46c650fc/PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html
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FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

1
1. scibot 17 Jul 2024
  
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  AB_210547
  
  DOI: 10.1016/j.celrep.2024.114464
  
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sciencedirect.com/science/article/pii/S2211124724007939
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

1
1. scibot 22 Jun 2024
  
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  RRID:AB_210547
  
  DOI: 10.1083/jcb.202402144
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

1
1. scibot 04 Jun 2024
  
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  AB_210547
  
  DOI: 10.1016/j.devcel.2024.05.010
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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sciencedirect.com/science/article/pii/S1534580724003277
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

2
1. scibot 25 Apr 2024
  
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  RRID:AB_210547
  
  DOI: 10.1083/jcb.202303141
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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2. scibot 25 Apr 2024
  
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  RRID:AB_210547
  
  DOI: 10.1083/jcb.202303141
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 06 Mar 2024
  
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  RRID:AB_210547
  
  DOI: 10.1038/s41467-024-45947-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
Feb 2024
aacrjournals.org aacrjournals.org

A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients

1
1. scibot 24 Feb 2024
  
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  RRID:AB_210547
  
  DOI: 10.1158/1078-0432.CCR-23-2005
  
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aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

1
1. scibot 08 Feb 2024
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.isci.2024.108925
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
Dec 2023
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

1
1. scibot 22 Dec 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.cell.2023.11.022
  
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sciencedirect.com/science/article/pii/S009286742301276X
52.53.155.43 52.53.155.43

ccr-23-2005-html.html

1
1. scibot 01 Dec 2023
  
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  RRID:AB_210547
  
  DOI: 10.1158/1078-0432.ccr-23-2005
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer

1
1. scibot 01 Oct 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.113144
  
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sciencedirect.com/science/article/pii/S2211124723011567
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

1
1. scibot 12 Sep 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress

1
1. scibot 26 Aug 2023
  
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  RRID:AB_210547
  
  DOI: 10.1158/2767-9764.CRC-23-0268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
52.53.155.43 52.53.155.43

crc-23-0268-html.html

1
1. scibot 11 Aug 2023
  
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  RRID:AB_210547
  
  DOI: 10.1158/2767-9764.crc-23-0268
  
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52.53.155.43/385511300daa3e14cefdae67d8cec9d074c7314f/crc-23-0268-html.html
Jul 2023
www.sciencedirect.com www.sciencedirect.com

MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

1
1. scibot 21 Jul 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

1
1. scibot 20 Apr 2023
  
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  RRID:AB_210547
  
  DOI: 10.1126/sciadv.ade7997
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
www.science.org www.science.org

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

1
1. scibot 20 Apr 2023
  
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  RRID:AB_210547
  
  DOI: 10.1126/sciadv.ade7997
  
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science.org/doi/10.1126/sciadv.ade7997
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ERCC6L2 mitigates replication stress and promotes centromere stability

1
1. scibot 06 Apr 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.112329
  
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sciencedirect.com/science/article/pii/S2211124723003406
Mar 2023
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HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

1
1. scibot 23 Mar 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.112284
  
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sciencedirect.com/science/article/pii/S2211124723002954
Jan 2023
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Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

1
1. scibot 31 Jan 2023
  
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  RRID:AB_210547
  
  DOI: 10.1016/j.celrep.2023.112043
  
  Resource: (Bethyl Cat# A300-245A, RRID:AB_210547)
  
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SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses

1
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  DOI: 10.1016/j.molcel.2023.01.003
  
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Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

1
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  DOI: 10.1016/j.cell.2022.12.036
  
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Replication stress defines distinct molecular subtypes across cancers

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  DOI: 10.1158/2767-9764.crc-22-0168
  
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

1
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  DOI: 10.1016/j.celrep.2022.111600
  
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Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

1
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  DOI: 10.1016/j.isci.2022.104944
  
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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

1
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  DOI: 10.1016/j.molcel.2022.03.030
  
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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

1
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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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  DOI: 10.1038/s41598-022-09308-4
  
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BMI-1 regulates DNA end resection and homologous recombination repair

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WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

1
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  DOI: 10.1016/j.celrep.2021.110261
  
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Nov 2021
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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

1
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Oct 2021
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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

1
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Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations

1
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  DOI: 10.1016/j.celrep.2021.109673
  
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Aug 2021
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BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication

1
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  DOI: 10.1016/j.celrep.2018.10.079
  
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Untitled document

1
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  DOI: 10.7554/eLife.38771
  
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Jul 2021
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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

1
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  DOI: 10.1016/j.molcel.2018.04.023
  
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Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment

1
1. scibot 30 Jul 2021
  
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  anti‐phospho S4/S8 RPA2
  
  DOI: 10.1002/ijc.32670
  
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onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
May 2021
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Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

1
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  DOI: 10.1016/j.molcel.2020.06.028
  
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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

1
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  DOI: 10.1016/j.molcel.2020.04.031
  
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

1
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  DOI: 10.1016/j.ccell.2020.11.004
  
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Functional interrogation of DNA damage response variants with base editing screens

1
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  DOI: 10.1016/j.cell.2021.01.041
  
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Mar 2021
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

1
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  DOI: 10.1016/j.celrep.2021.108808
  
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Feb 2021
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Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

1
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  DOI: 10.1038/s41418-020-00733-4
  
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nature.com/articles/s41418-020-00733-4
Jan 2021
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DCAF14 promotes stalled fork stability to maintain genome integrity

1
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

1
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  DOI: 10.1016/j.molcel.2020.12.025
  
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Dec 2020
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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

1
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  DOI: 10.1016/j.celrep.2020.108469
  
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sciencedirect.com/science/article/pii/S2211124720314583
Sep 2020
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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

1
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  DOI: 10.1016/j.celrep.2020.107983
  
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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

1
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  DOI: 10.1016/j.ccell.2020.04.002
  
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ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

1
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  DOI: 10.1016/j.celrep.2020.108096
  
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genesdev.cshlp.org genesdev.cshlp.org

Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne

1
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  pRPA32
  
  DOI: 10.1101/gad.332395.119
  
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genesdev.cshlp.org/content/33/23-24/1702.full
Jan 2020
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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

1
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  DOI: 10.1016/j.ccell.2019.05.001
  
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www.embopress.org www.embopress.org

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

1
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  RRID:AB_210547
  
  DOI: 10.15252/embj.2019102361
  
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embopress.org/doi/10.15252/embj.2019102361
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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

1
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  DOI: 10.1016/j.celrep.2019.06.043
  
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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

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RPA Phosphorylation Inhibits DNA Resection

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LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

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ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

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Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

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Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

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SLFN11 Blocks Stressed Replication Forks Independently of ATR

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Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

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Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH

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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres

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