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  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner
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    1. scibot 21 Dec 2024
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      DOI: 10.1101/2024.12.01.626256

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    pmc.ncbi.nlm.nih.gov/articles/PMC11642733/
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S1097276524009894
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    1. scibot 21 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115104

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    sciencedirect.com/science/article/pii/S2211124724014554
  5. Nov 2024
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    1. scibot 14 Nov 2024
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  8. Sep 2024
  9. www.sciencedirect.com www.sciencedirect.com
    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    1. scibot 25 Sep 2024
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  10. Jul 2024
  11. 52.53.155.43 52.53.155.43
    PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html
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    1. scibot 23 Jul 2024
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
    1. scibot 17 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124724007939
  13. Jun 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
    1
    1. scibot 22 Jun 2024
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      DOI: 10.1083/jcb.202402144

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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
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  16. Apr 2024
  17. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
    1. scibot 25 Apr 2024
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      DOI: 10.1083/jcb.202303141

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      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  18. Mar 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1038/s41467-024-45947-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  20. Feb 2024
  21. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1158/1078-0432.CCR-23-2005

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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1016/j.isci.2024.108925

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  23. Dec 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.022

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    sciencedirect.com/science/article/pii/S009286742301276X
  25. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
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  26. Oct 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
    1
    1. scibot 01 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113144

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    sciencedirect.com/science/article/pii/S2211124723011567
  28. Sep 2023
  29. www.sciencedirect.com www.sciencedirect.com
    The interplay of TARG1 and PARG protects against genomic instability
    1
    1. scibot 12 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113113

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    sciencedirect.com/science/article/pii/S2211124723011245
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
    1
    1. scibot 26 Aug 2023
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      DOI: 10.1158/2767-9764.CRC-23-0268

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    ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
  32. 52.53.155.43 52.53.155.43
    crc-23-0268-html.html
    1
    1. scibot 11 Aug 2023
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  33. Jul 2023
  34. www.sciencedirect.com www.sciencedirect.com
    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
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    1. scibot 21 Jul 2023
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    sciencedirect.com/science/article/pii/S2211124723008161
  35. Apr 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
    1
    1. scibot 20 Apr 2023
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      DOI: 10.1126/sciadv.ade7997

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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
  37. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
    1
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      DOI: 10.1126/sciadv.ade7997

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  38. www.sciencedirect.com www.sciencedirect.com
    ERCC6L2 mitigates replication stress and promotes centromere stability
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112329

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    sciencedirect.com/science/article/pii/S2211124723003406
  39. Mar 2023
  40. www.sciencedirect.com www.sciencedirect.com
    HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
    1
    1. scibot 23 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112284

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    sciencedirect.com/science/article/pii/S2211124723002954
  41. Jan 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Elevated PAF1-RAD52 axis confers chemoresistance to human cancers
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    1. scibot 31 Jan 2023
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      DOI: 10.1016/j.celrep.2023.112043

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    sciencedirect.com/science/article/pii/S2211124723000542
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.molcel.2023.01.003

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    sciencedirect.com/science/article/pii/S1097276523000035
  44. www.sciencedirect.com www.sciencedirect.com
    Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
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    1. scibot 21 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.036

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    sciencedirect.com/science/article/pii/S0092867422015793
  45. Nov 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Replication stress defines distinct molecular subtypes across cancers
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      DOI: 10.1158/2767-9764.crc-22-0168

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    ncbi.nlm.nih.gov/pmc/articles/PMC9648410/
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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      DOI: 10.1016/j.celrep.2022.111716

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    sciencedirect.com/science/article/pii/S2211124722015947
  48. www.sciencedirect.com www.sciencedirect.com
    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
    1
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      DOI: 10.1016/j.celrep.2022.111600

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    sciencedirect.com/science/article/pii/S2211124722014656
  49. Aug 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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      DOI: 10.1016/j.isci.2022.104944

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    sciencedirect.com/science/article/pii/S2589004222012160
  51. Apr 2022
  52. www.sciencedirect.com www.sciencedirect.com
    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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      DOI: 10.1016/j.molcel.2022.03.030

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    sciencedirect.com/science/article/pii/S1097276522002684
  53. www.sciencedirect.com www.sciencedirect.com
    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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      DOI: 10.1016/j.molcel.2022.03.031

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    sciencedirect.com/science/article/pii/S1097276522002696
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  55. Mar 2022
  56. www.sciencedirect.com www.sciencedirect.com
    BMI-1 regulates DNA end resection and homologous recombination repair
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      DOI: 10.1016/j.celrep.2022.110536

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    sciencedirect.com/science/article/pii/S2211124722002777
  57. Jan 2022
  58. www.sciencedirect.com www.sciencedirect.com
    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110261

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    sciencedirect.com/science/article/pii/S2211124721017733
  59. Nov 2021
  60. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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      DOI: 10.1016/j.molcel.2021.11.002

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  61. Oct 2021
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    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
    1
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  63. Sep 2021
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    Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations
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      DOI: 10.1016/j.celrep.2021.109673

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  65. Aug 2021
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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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      DOI: 10.1016/j.celrep.2018.10.079

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  67. europepmc.org europepmc.org
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  68. Jul 2021
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    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
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  70. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
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      anti‐phospho S4/S8 RPA2

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  71. May 2021
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    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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  74. Apr 2021
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    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    Functional interrogation of DNA damage response variants with base editing screens
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  77. Mar 2021
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    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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  79. Feb 2021
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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      DOI: 10.1038/s41418-020-00733-4

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  81. Jan 2021
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    DCAF14 promotes stalled fork stability to maintain genome integrity
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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  84. Dec 2020
  85. www.sciencedirect.com www.sciencedirect.com
    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
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  86. Sep 2020
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2020.108096

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  90. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
    1
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      pRPA32

      DOI: 10.1101/gad.332395.119

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  91. Jan 2020
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    Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
    1
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      RRID:AB_210547

      DOI: 10.1016/j.ccell.2019.05.001

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  93. www.embopress.org www.embopress.org
    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
    1
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      RRID:AB_210547

      DOI: 10.15252/embj.2019102361

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    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
    1
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2019.06.043

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    Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations
    1
    1. scibot 13 Jan 2020
      RRID:AB_210547

      DOI: 10.1016/j.molcel.2019.05.015

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    RPA Phosphorylation Inhibits DNA Resection
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      RRID:AB_210547

      DOI: 10.1016/j.molcel.2019.05.005

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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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      RRID:AB_210547

      DOI: 10.1016/j.ccell.2019.07.007

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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
    1
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2019.09.008

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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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      RRID:AB_210547

      DOI: 10.1016/j.cels.2019.11.001

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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2019.11.012

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    sciencedirect.com/science/article/pii/S2211124719314834
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2019.01.013

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      DOI: 10.1016/j.molcel.2018.11.036

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      RRID:AB_210547

      DOI: 10.1016/j.molcel.2018.12.010

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    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
    1
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      RRID:AB_210547

      DOI: 10.1016/j.molcel.2019.04.003

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      DOI: 10.1016/j.molcel.2019.04.024

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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
    1
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      RRID:AB_210547

      DOI: 10.1016/j.celrep.2019.05.002

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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
    1
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      RRID:AB_210547

      DOI: 10.1016/j.ccell.2019.02.004

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  108. Nov 2018
  109. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6039718/
  113. www.sciencedirect.com www.sciencedirect.com
    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
    1
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      RRID:AB_210547

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    sciencedirect.com/science/article/pii/S1097276518303927
  114. www.sciencedirect.com www.sciencedirect.com
    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
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      RRID:AB_210547

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    sciencedirect.com/science/article/pii/S1097276518303459
  115. www.sciencedirect.com www.sciencedirect.com
    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
    1
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    sciencedirect.com/science/article/pii/S1535610818301818
  116. www.sciencedirect.com www.sciencedirect.com
    SLFN11 Blocks Stressed Replication Forks Independently of ATR
    1
    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1097276518300418
  117. elifesciences.org elifesciences.org
    Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations
    1
    1. scibot 05 Nov 2018
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      Curator: @evieth

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    elifesciences.org/articles/32222
  118. www.sciencedirect.com www.sciencedirect.com
    The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_210547

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518300601
  119. www.sciencedirect.com www.sciencedirect.com
    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
    1
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    sciencedirect.com/science/article/pii/S1535610818300199
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  121. www.sciencedirect.com www.sciencedirect.com
    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
    1
    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518301412
  122. www.sciencedirect.com www.sciencedirect.com
    The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
    1
    1. scibot 05 Nov 2018
      RRID:AB_210547

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517310080
  123. www.sciencedirect.com www.sciencedirect.com
    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
    1
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      RRID:AB_210547

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    sciencedirect.com/science/article/pii/S1097276517308808
  124. www.sciencedirect.com www.sciencedirect.com
    Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
    1
    1. scibot 05 Nov 2018
      RRID:AB_210547

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    sciencedirect.com/science/article/pii/S1535610817304592
  125. www.sciencedirect.com www.sciencedirect.com
    Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH
    1
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      RRID:AB_210547

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    sciencedirect.com/science/article/pii/S1097276517307967
  126. Nov 2017
  127. www.sciencedirect.com www.sciencedirect.com
    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
    1
    1. scibot 08 Nov 2017
      RRID:AB_210547

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867417308796
  128. www.sciencedirect.com www.sciencedirect.com
    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
    1
    1. scibot 08 Nov 2017
      AB_210547

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517304574
  129. www.sciencedirect.com www.sciencedirect.com
    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
    1
    1. scibot 08 Nov 2017
      AB_210547

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517302782
  130. www.sciencedirect.com www.sciencedirect.com
    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
    1
    1. scibot 08 Nov 2017
      AB_210547

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517300424