642 Matching Annotations
  1. Sep 2024
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
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    sciencedirect.com/science/article/pii/S2211124720311906
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    Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
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    sciencedirect.com/science/article/pii/S235239642030253X
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    Identification of a Master Regulator of Differentiation in Toxoplasma
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    sciencedirect.com/science/article/pii/S0092867419313753
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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11398899/
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    Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin
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    sciencedirect.com/science/article/pii/S1931312824003196
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    Pooled endogenous protein tagging and recruitment for systematic profiling of protein function
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    sciencedirect.com/science/article/pii/S2666979X24002623
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369174/
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    Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11371324/
  11. Aug 2024
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    The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350185/
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    Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma
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    Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC6551610/
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
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    Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions
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    The cullin Rtt101 promotes ubiquitin-dependent DNA−protein crosslink repair across the cell cycle
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    Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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  21. Jul 2024
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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    Observing isolated synaptic vesicle association and fusion ex vivo
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    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    Polymerization of ZBTB transcription factors regulates chromatin occupancy
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    Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11179071/
  27. Jun 2024
  28. www.cell.com www.cell.com
    Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
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    The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres
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    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
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    Truncated protein isoforms generate diversity of protein localization and function in yeast
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  36. 52.53.155.43 52.53.155.43
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  38. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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    ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
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    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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    Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins
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    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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  48. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    Revealing the grammar of small RNA secretion using interpretable machine learning
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  52. 52.53.155.43 52.53.155.43
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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  57. Mar 2024
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    Molecular determinants and signaling effects of PKA RIα phase separation
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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  63. Feb 2024
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    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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    Identification of an H-Ras nanocluster disrupting peptide
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    UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
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    link.springer.com/article/10.1038/s41586-024-07073-0
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis-linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration
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    onlinelibrary.wiley.com/doi/10.1002/glia.24516
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  69. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  74. Dec 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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  76. Nov 2023
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
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  81. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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    ncbi.nlm.nih.gov/pmc/articles/PMC10150294/
  87. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  88. Oct 2023
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    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10572190/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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  96. www.cell.com www.cell.com
    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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  97. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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  202. Apr 2022
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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  213. Feb 2022
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas
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  219. Jan 2022
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