828 Matching Annotations
  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
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    sciencedirect.com/science/article/pii/S235239642030253X
  3. elifesciences.org elifesciences.org
    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
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    elifesciences.org/articles/50519
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S1535610819305239
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Corticosterone primes the neuroinflammatory response to Gulf War Illness‐relevant organophosphates independently of acetylcholinesterase inhibition
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14071/full
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    Protein UFMylation regulates early events during ribosomal DNA-damage response
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    sciencedirect.com/science/article/pii/S2211124724010891
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    Protofilament-specific nanopatterns of tubulin post-translational modifications regulate the mechanics of ciliary beating
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    sciencedirect.com/science/article/pii/S0960982224011333
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    Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11382127/
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    Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin
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    sciencedirect.com/science/article/pii/S1931312824003196
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    mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S2666379124004385
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    sciencedirect.com/science/article/pii/S009286742400905X
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    Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ
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    sciencedirect.com/science/article/pii/S2211124724010465
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    o-guinn-et-al-2024-fxr-deletion-attenuates-intestinal-barrier-dysfunction-in-murine-acute-intestinal-inflammation-html.html
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    IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC11371365/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362472/
  16. Aug 2024
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    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
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    sciencedirect.com/science/article/pii/S266637912400421X
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    Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
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    sciencedirect.com/science/article/pii/S2211124724010325
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10530441/
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    Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
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    sciencedirect.com/science/article/pii/S1550413124002912
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    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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    Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
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    sciencedirect.com/science/article/pii/S2211124724009665
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    sciencedirect.com/science/article/pii/S2211124724009677
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    The lateral habenula integrates age and experience to promote social transitions in developing rats
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    sciencedirect.com/science/article/pii/S2211124724008854
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    The fork protection complex promotes parental histone recycling and epigenetic memory
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    sciencedirect.com/science/article/pii/S0092867424007773
  26. elifesciences.org elifesciences.org
    Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
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    elifesciences.org/content/4/e06434
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    Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model
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    frontiersin.org/article/10.3389/fneur.2020.602292/full
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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    sciencedirect.com/science/article/pii/S1097276524005793
  29. Jul 2024
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    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BTK acts as a modulator of the response to imatinib in chronic myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11253089/
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16439
  34. www.nature.com www.nature.com
    Observing isolated synaptic vesicle association and fusion ex vivo
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    nature.com/articles/s41596-024-01014-x
  35. www.cell.com www.cell.com
    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    cell.com/molecular-cell/fulltext/S1097-2765(24)00511-2
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    Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1
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    sciencedirect.com/science/article/pii/S0969212624002284
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11179071/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release
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    ncbi.nlm.nih.gov/pmc/articles/PMC10591831/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to study CCT-mediated folding of Gβ5 by single-particle cryo-EM
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215110/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  41. Jun 2024
  42. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16473
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
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    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
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    sciencedirect.com/science/article/pii/S0021925824019707
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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    sciencedirect.com/science/article/pii/S1567576924008944
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
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    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
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    sciencedirect.com/science/article/pii/S2589004224011623
  48. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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  49. Local file Local file
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  50. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    sciencedirect.com/science/article/pii/S1534580724002995
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11071352/
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    Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants
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    sciencedirect.com/science/article/pii/S1097276524003277
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    Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics
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    sciencedirect.com/science/article/pii/S1934590924001449
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    The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking
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    sciencedirect.com/science/article/pii/S2211124724005357
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379124002520
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  59. www.biorxiv.org www.biorxiv.org
    Identification of novel and distinct FGF23 signaling in a Klotho-dependent and -independent manner
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    biorxiv.org/content/10.1101/2024.01.18.576116v1
  60. www.mdpi.com www.mdpi.com
    Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
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  61. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    BAG3 regulates cilia homeostasis of glioblastoma via its WW domain
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    iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.2060
  62. Apr 2024
  63. www.sciencedirect.com www.sciencedirect.com
    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors
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    sciencedirect.com/science/article/pii/S2211124724004716
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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  66. 52.53.155.43 52.53.155.43
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    Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
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    nature.com/articles/s41598-024-59013-7
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10995880/
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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    sciencedirect.com/science/article/pii/S2211124724004030
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    sciencedirect.com/science/article/pii/S2211124724003528
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    nature.com/articles/s41419-024-06534-8
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
  75. Mar 2024
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    ncbi.nlm.nih.gov/pmc/articles/PMC10950329/
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209755/
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
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    ncbi.nlm.nih.gov/pmc/articles/PMC10919853/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10904759/
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    Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT
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    sciencedirect.com/science/article/pii/S2211124724002092
  83. Feb 2024
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    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124724001591
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    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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    Alternative mRNA splicing events and regulators in epidermal differentiation
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    sciencedirect.com/science/article/pii/S2211124724001426
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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    ncbi.nlm.nih.gov/pmc/articles/PMC10982971/
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  89. 52.53.155.43 52.53.155.43
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    52.53.155.43/d532629e4f1cf755a6f5c302a21018f2c97350c4/reisbeck-et-al-2023-the-iron-chelator-and-oxphos-inhibitor-vlx600-induces-mitophagy-and-an-autophagy-dependent-type-of (1)-html.html
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    UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
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    link.springer.com/article/10.1038/s41586-024-07073-0
  91. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    journals.physiology.org/doi/10.1152/ajpcell.00293.2023
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    sciencedirect.com/science/article/pii/S1534580724000443
  93. 52.53.155.43 52.53.155.43
    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling
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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers
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  199. Mar 2023
  200. 52.53.155.43 52.53.155.43
    Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis
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    S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signaling
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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  207. Feb 2023
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    Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
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    Inducing primary brainstem gliomas in genetically engineered mice using RCAS/TVA retroviruses and Cre/loxP recombination
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