809 Matching Annotations
  1. Dec 2024
  2. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13773
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    Circular RNAs trigger nonsense-mediated mRNA decay
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    sciencedirect.com/science/article/pii/S109727652400947X
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC11621922/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimized reporters for multiplexed detection of transcription factor activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667439/
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    Dual BACH1 regulation by complementary SCF-type E3 ligases
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    sciencedirect.com/science/article/pii/S0092867424013229
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    Reactive oxygen species control protein degradation at the mitochondrial import gate
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    sciencedirect.com/science/article/pii/S1097276524009092
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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    sciencedirect.com/science/article/pii/S1097276524009146
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    The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma
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    sciencedirect.com/science/article/pii/S221112472401386X
  10. www.nature.com www.nature.com
    ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ
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    nature.com/articles/s41596-024-01071-2
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    Nuclear Factor I family members are key transcription factors regulating gene expression
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    sciencedirect.com/science/article/pii/S1535947624001804
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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    sciencedirect.com/science/article/pii/S2211124724013676
  14. Nov 2024
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
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    The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability
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    sciencedirect.com/science/article/pii/S0021925824024980
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11286238/
  18. www.nature.com www.nature.com
    Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
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    nature.com/articles/s41596-024-01075-y
  19. Oct 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11444770/
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    Pervasive mislocalization of pathogenic coding variants underlying human disorders
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    sciencedirect.com/science/article/pii/S0092867424010213
  22. Sep 2024
  23. www.nature.com www.nature.com
    Rapid generation of homozygous fluorescent knock-in human cells using CRISPR–Cas9 genome editing and validation by automated imaging and digital PCR screening
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    nature.com/articles/s41596-024-01043-6
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand
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    ncbi.nlm.nih.gov/pmc/articles/PMC11416401/
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  26. elifesciences.org elifesciences.org
    A mechanism in Agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome
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    elifesciences.org/articles/49180
  27. elifesciences.org elifesciences.org
    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice
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    elifesciences.org/articles/45303
  28. elifesciences.org elifesciences.org
    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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    elifesciences.org/articles/34836
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    C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function
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    sciencedirect.com/science/article/pii/S1097276519302230
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    sciencedirect.com/science/article/pii/S0092867418313084
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    europepmc.org/articles/PMC5957528/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Protocol to study the direct binding of proteins to RNA:DNA hybrids or RNA-DNA chimeras in living cells using cross-linking immunoprecipitation
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    sciencedirect.com/science/article/pii/S266616672400457X
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    A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein
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    sciencedirect.com/science/article/pii/S2211124724010787
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    Conserved cysteine-switches for redox sensing operate in the Cyclin-Dependent Kinase Inhibitor p21(CIP/KIP) Protein Family.
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    sciencedirect.com/science/article/pii/S0891584924006609
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    A compact, versatile drug-induced splicing switch system with minimal background expression
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    sciencedirect.com/science/article/pii/S2667237524002157
  37. Aug 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335261/
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    Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity
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    sciencedirect.com/science/article/pii/S0092867424008286
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11323502/
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    Optogenetic control of kinesin-1, -2, -3 and dynein reveals their specific roles in vesicular transport
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    sciencedirect.com/science/article/pii/S2211124724010003
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11311709/
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    Structural requirements for activity of Mind bomb1 in Notch signaling
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    sciencedirect.com/science/article/pii/S0969212624002740
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    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
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    sciencedirect.com/science/article/pii/S2211124724009239
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    Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay
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    sciencedirect.com/org/science/article/pii/S1520480424003053
  46. www.cell.com www.cell.com
    Neotelomeres and telomere-spanning chromosomal arm fusions in cancer genomes revealed by long-read sequencing
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    cell.com/cell-genomics/fulltext/S2666-979X(24)00172-1
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MTF2 facilitates the advancement of osteosarcoma through mediating EZH2/SFRP1/Wnt signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11312803/
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    Generation of densely labeled oligonucleotides for the detection of small genomic elements
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    sciencedirect.com/science/article/pii/S2667237524002133
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulating tumor-associated macrophage polarization by anti-maRCO mAb exerts anti-osteosarcoma effects through regulating osteosarcoma cell proliferation, migration and apoptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11290128/
  51. aacrjournals.org aacrjournals.org
    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
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    aacrjournals.org/cancerrescommun/article/3/10/2030/729478/Piperacetazine-Directly-Binds-to-the-PAX3-FOXO1
  52. www.science.org www.science.org
    Posttranslational modification of microtubules by the MATCAP detyrosinase
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    science.org/doi/10.1126/science.abn6020
  53. www.cell.com www.cell.com
    Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin
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    cell.com/current-biology/fulltext/S0960-9822(20)31768-1
  54. www.mdpi.com www.mdpi.com
    Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile
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    mdpi.com/1420-3049/26/4/794/htm
  55. bio-protocol.org bio-protocol.org
    Protocol for Establishing a Multiplex Image-based Autophagy ...
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    bio-protocol.org/e2540
  56. Jul 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the main barriers to Ku accumulation in chromatin
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
  58. www.biorxiv.org www.biorxiv.org
    Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cells
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    biorxiv.org/content/10.1101/2024.07.21.604463v1
  59. www.sciencedirect.com www.sciencedirect.com
    Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004224015013
  60. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    AXIN2 promotes degradation of AXIN1 through tankyrase in colorectal cancer cells
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    febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.17226
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7556861/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterising replisome disassembly in human cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269944/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11240082/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11233918/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238136/
  66. academic.oup.com academic.oup.com
    A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae563/7701480
  67. journals.asm.org journals.asm.org
    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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    journals.asm.org/doi/10.1128/mbio.01117-24
  68. Jun 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  70. www.nature.com www.nature.com
    An intermediate Rb–E2F activity state safeguards proliferation commitment
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    nature.com/articles/s41586-024-07554-2
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres
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    ncbi.nlm.nih.gov/pmc/articles/PMC11188873/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fully automated viability and toxicity screening—A reliable all‐in‐one attempt
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    ncbi.nlm.nih.gov/pmc/articles/PMC11193055/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Illuminating Dark Chemical Matter Using the Cell Painting Assay
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    ncbi.nlm.nih.gov/pmc/articles/PMC11181314/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small-Molecule Inhibition of CBX4/7 Hypersensitises Homologous Recombination-Impaired Cancer to Radiation by Compromising CtIP-Mediated DNA End Resection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11172190/
  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A comparative analysis of paxillin and Hic-5 proximity interactomes
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    onlinelibrary.wiley.com/doi/10.1002/cm.21878
  76. www.sciencedirect.com www.sciencedirect.com
    Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
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    sciencedirect.com/science/article/pii/S2211124724006442
  77. May 2024
  78. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Doxorubicin induces deglycosylation of cancer cell-intrinsic PD-1 by NGLY1
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14935
  79. www.biorxiv.org www.biorxiv.org
    Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis
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    biorxiv.org/content/10.1101/2024.03.13.584906v1
  80. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
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    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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    sciencedirect.com/science/article/pii/S2211124724005424
  82. www.sciencedirect.com www.sciencedirect.com
    Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
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    sciencedirect.com/science/article/pii/S1097276524003290
  83. 52.53.155.43 52.53.155.43
    Centriolar satellites are sites of translation of centrosomal and ciliary proteins
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    52.53.155.43/b4facf67b457be9515b769549e8e513b0c45add0/2024.02.22.581531v1.full-html.html
  84. journals.biologists.com journals.biologists.com
    Ferroptosis induces membrane blebbing in placental trophoblasts
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    journals.biologists.com/jcs/article/135/5/jcs255737/224124/Ferroptosis-induces-membrane-blebbing-in-placental
  85. 52.53.155.43 52.53.155.43
    Intracellular delivery of oncolytic viruses with engineered Salmonella causes viral replication and cell death
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    52.53.155.43/6ccee77371dd354552d7d5ac3781151e9655f8d3/PIIS2589004224010356-html.html
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    The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ
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    sciencedirect.com/science/article/pii/S2352396424001592
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    A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture
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    sciencedirect.com/science/article/pii/S0960982224004688
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data
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    ncbi.nlm.nih.gov/pmc/articles/PMC11039982/
  89. Apr 2024
  90. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S109727652400282X
  91. www.sciencedirect.com www.sciencedirect.com
    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    sciencedirect.com/science/article/pii/S1550413124001232
  92. aacrjournals.org aacrjournals.org
    miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress
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    aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
  93. www.embopress.org www.embopress.org
    RAD51 restricts DNA over-replication from re-activated origins
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    embopress.org/doi/full/10.1038/s44318-024-00038-z
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    DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
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    sciencedirect.com/science/article/pii/S2405471224000887
  95. www.biorxiv.org www.biorxiv.org
    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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    biorxiv.org/content/10.1101/2024.04.07.588476v1
  96. www.sciencedirect.com www.sciencedirect.com
    Time-series reconstruction of the molecular architecture of human centriole assembly
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    sciencedirect.com/science/article/pii/S0092867424003167
  97. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  194. May 2023
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    p300 Is an Obligate Integrator of Combinatorial Transcription Factor Inputs
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals
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  203. Apr 2023
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    Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
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