1,124 Matching Annotations
  1. Mar 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
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    Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells
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    1. scibot 05 Mar 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444958/
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    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444962/
  5. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    1. scibot 03 Mar 2023
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    sciencedirect.com/science/article/pii/S1535610823000326
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    BPS Publications
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    1. scibot 03 Mar 2023
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16047
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    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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      DOI: 10.1111/jnc.15764

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15764
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    sciencedirect.com/science/article/pii/S2211124723001997
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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    LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla
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      DOI: 10.1111/cns.14142

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  11. Feb 2023
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    PIMT regulates Hepatic Gluconeogenesis in Mice
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    sciencedirect.com/science/article/pii/S2589004223001979
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    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment
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    1. scibot 23 Feb 2023
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation
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    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
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  18. 52.53.155.43 52.53.155.43
    bcd-22-0082-html.html
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  19. www.biorxiv.org www.biorxiv.org
    The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation
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    biorxiv.org/content/10.1101/2023.01.03.522612v1
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    1. scibot 09 Feb 2023
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    Regulation of DNA damage response by trimeric G-proteins
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    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
    1
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      DOI: 10.3390/ijms24032983

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    mdpi.com/1422-0067/24/3/2983
  23. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    sciencedirect.com/science/article/pii/S153561082300003X
  24. Jan 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance
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  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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  28. academic.oup.com academic.oup.com
    Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice
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    Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells
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    Autotaxin facilitates selective LPA receptor signaling
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  31. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
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    Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
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      DOI: 10.1007/s12035-022-03182-x

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    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
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  37. Dec 2022
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    mdpi.com/2072-6643/14/24/5265
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    Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
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    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
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      DOI: 10.1007/s00018-022-04638-y

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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
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    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    sciencedirect.com/science/article/pii/S1550413122005034
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
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    Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats
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    Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    Morusin Protected Ruminal Epithelial Cells against Lipopolysaccharide-Induced Inflammation through Inhibiting EGFR-AKT/NF-κB Signaling and Improving Barrier Functions
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    Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation
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    Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis
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    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
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    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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    Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
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    Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
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    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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    Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth
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    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
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      Rabbit polyclonal anti-pAKT (Ser473)

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    Multiplexed protein profiling reveals spatial subcellular signaling networks
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
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    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
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    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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  146. Apr 2022
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    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography
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    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide
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    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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    PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation
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    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    Coordinated changes in glycosylation regulate the germinal center through CD22
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    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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    Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
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    Regulation of GTPase function by autophosphorylation
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    Pathway-specific effects of ADSL deficiency on neurodevelopment
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
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    Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling
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    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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    The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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