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Sep 2024
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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114739
  
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sciencedirect.com/science/article/pii/S2211124724010908
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Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function

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1. scibot 13 Sep 2024
  
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  DOI: 10.1016/j.neuron.2024.08.009
  
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Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110683
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11382127/
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TGF-β and RAS jointly unmask primed enhancers to drive metastasis

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.014
  
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sciencedirect.com/science/article/pii/S009286742400905X
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Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ

1
1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114695
  
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sciencedirect.com/science/article/pii/S2211124724010465
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.014
  
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CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

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1. scibot 04 Sep 2024
  
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  DOI: 10.7554/eLife.94245
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11368403/
Aug 2024
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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

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1. scibot 29 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114682
  
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sciencedirect.com/science/article/pii/S2211124724010337
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Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection

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1. scibot 28 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110711
  
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sciencedirect.com/science/article/pii/S2589004224019369
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Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

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1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.neuron.2024.07.025
  
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The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

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1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114666
  
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sciencedirect.com/science/article/pii/S2211124724010179
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Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

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1. scibot 26 Aug 2024
  
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  DOI: 10.7554/eLife.94407
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11343564/
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CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

1
1. scibot 23 Aug 2024
  
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  AB_262044
  
  DOI: 10.1016/j.celrep.2024.114662
  
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Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110592
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11378969/
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Acetate enables metabolic fitness and cognitive performance during sleep disruption

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.019
  
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sciencedirect.com/science/article/pii/S1550413124002900
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TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114604
  
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sciencedirect.com/science/article/pii/S2211124724009549
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Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA

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1. scibot 22 Aug 2024
  
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  DOI: 10.1093/genetics/iyae120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11457939/
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A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.stem.2024.07.006
  
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sciencedirect.com/science/article/pii/S193459092400256X
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
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The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

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1. scibot 21 Aug 2024
  
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  DOI: 10.1085/jgp.202313518
  
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dx.doi.org/10.1085/jgp.202313518
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Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.07.017
  
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sciencedirect.com/science/article/pii/S1097276524005938
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The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114617
  
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sciencedirect.com/science/article/pii/S2211124724009677
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SLC25A48 controls mitochondrial choline import and metabolism

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.010
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00281-X
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RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

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1. scibot 20 Aug 2024
  
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  AB_262044
  
  DOI: 10.1016/j.celrep.2024.114594
  
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sciencedirect.com/science/article/pii/S2211124724009239
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Small GTPase ActIvitY ANalyzing (SAIYAN) system: A method to detect GTPase activation in living cells

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1. scibot 20 Aug 2024
  
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  DOI: 10.1083/jcb.202403179
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11303508/
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110499
  
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sciencedirect.com/science/article/pii/S2589004224017243
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Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114589
  
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sciencedirect.com/science/article/pii/S2211124724009185
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FolIws1-driven nuclear translocation of deacetylated FolTFIIS ensures conidiation of Fusarium oxysporum

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114588
  
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sciencedirect.com/science/article/pii/S2211124724009173
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.immuni.2024.07.010
  
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sciencedirect.com/science/article/pii/S1074761324003595
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Quantifying genome-wide transcription factor binding affinities for chromatin using BANC-seq

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1. scibot 19 Aug 2024
  
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  DOI: 10.1038/s41596-024-01026-7
  
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nature.com/articles/s41596-024-01026-7
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CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex

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1. scibot 18 Aug 2024
  
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  AB_262044
  
  DOI: 10.1083/jcb.202305087
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10818064/
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Sestrin2 drives ER-phagy in response to protein misfolding

1
1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.07.004
  
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sciencedirect.com/science/article/pii/S1534580724004416
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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

1
1. scibot 18 Aug 2024
  
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  AB_262044
  
  DOI: 10.1016/j.cell.2024.07.006
  
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sciencedirect.com/science/article/pii/S0092867424007669
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SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways

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1. scibot 02 Aug 2024
  
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  F1804
  
  DOI: 10.1126/scisignal.abc7611
  
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science.org/doi/10.1126/scisignal.abc7611
www.tandfonline.com www.tandfonline.com

M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

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1. scibot 02 Aug 2024
  
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  F1804
  
  DOI: 10.1080/15548627.2021.1938912
  
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tandfonline.com/doi/full/10.1080/15548627.2021.1938912
molecularbrain.biomedcentral.com molecularbrain.biomedcentral.com

LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron

1
1. scibot 02 Aug 2024
  
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  Anti-Flag
  
  DOI: 10.1186/s13041-020-00708-z
  
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Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain

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Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain

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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

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ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins

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A CPF-like phosphatase module links transcription termination to chromatin silencing

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1-s2.0-S2589004224017851-main-html.html

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Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis

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Arabidopsis COP1 suppresses root hair development by targeting type I ACS proteins for ubiquitination and degradation

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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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Structural insights into the role and targeting of EGFRvIII

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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism

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PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html

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Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

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Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis

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PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

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Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection

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Dimerization of hub protein DYNLL1 and bZIP transcription factor CREB3L1 enhances transcriptional activation of CREB3L1 target genes like arginine vasopressin

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The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules

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Regulation of the DLC3 tumor suppressor by a novel phosphoswitch

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Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

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Leep2A and Leep2B function as a RasGAP complex to regulate macropinosome formation

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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

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ASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor

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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

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Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1

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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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Drosophila model to study Retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion

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Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1

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Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching

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Chromosome compaction is triggered by an autonomous DNA-binding module within condensin

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Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

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CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

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The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation

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RDH12 allows cone photoreceptors to regenerate opsin visual pigments from a chromophore precursor to escape competition with rods

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Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells

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Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

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The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

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Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

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ROS are required for the germinative cell proliferation and metacestode larval growth of Echinococcus multilocularis

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KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

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LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos

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Dzip1 is dynamically expressed in the vertebrate germline and regulates the development of Xenopus primordial germ cells

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state

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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing

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SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms

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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

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Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function

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Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro

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RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly

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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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Conversion of natural cytokine receptors into orthogonal synthetic biosensors

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Distinct roles of TREM2 in central nervous system cancers and peripheral cancers

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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor

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Active nuclear positioning and actomyosin contractility maintain leader cell integrity during gonadogenesis

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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease

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Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

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TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains

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Whi5 hypo- and hyper-phosphorylation dynamics control cell-cycle entry and progression

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EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells

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The deubiquitylating enzyme Fat Facets modulates Fat signalling and regulates tissue growth

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Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders

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Synchronizing Drosophila larvae with the salivary gland reporter Sgs3-GFP for discovery of phenotypes in the late third instar stage.

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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bqae039-html.html

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Ubiquitin-mediated regulation of APE2 protein abundance

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300

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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration

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A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture

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A critical suppression feedback loop determines soybean photoperiod sensitivity

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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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Protocol for efficient CRISPR-Cas9-mediated fluorescent tag knockin in hard-to-transfect erythroid cell lines

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ISGylation by HERCs facilitates STING activation

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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol

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Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome

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Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition

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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

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Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking

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SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion

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TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

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14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming

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Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host

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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

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Genotype-Phenotype Correlations in Thirty Japanese Patients with Congenital Hypothyroidism Attributable to TG Defects

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Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma

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  DOI: 10.1016/j.xcrm.2024.101484
  
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S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila

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Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation

1
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Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

1
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Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro

1
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Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins

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  DOI: 10.1111/jnc.16093
  
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The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases

1
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

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Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells

1
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

2
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Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene

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Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier

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The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

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Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells

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Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

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A gut-derived hormone regulates cholesterol metabolism

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  DOI: 10.1016/j.cell.2024.02.024
  
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

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  DOI: 10.7554/eLife.90993
  
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The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury

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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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Pla2g12b drives expansion of triglyceride-rich lipoproteins

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The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5

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JNEUROSCI.2031-23.2024.full-html.html

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Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.

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Alternative splicing decouples local from global PRC2 activity

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ALK upregulates POSTN and WNT signaling to drive neuroblastoma

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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Securin acetylation prevents precocious separase activation and premature sister chromatid separation

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  DOI: 10.1016/j.cub.2024.02.038
  
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Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer

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MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance

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SARS-CoV-2 targets ribosomal RNA biogenesis

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2. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113891
  
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Structure-based design of non-hypertrophic apelin receptor modulator

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  DOI: 10.1016/j.cell.2024.02.004
  
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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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  DOI: 10.1016/j.celrep.2024.113886
  
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

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NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP

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AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ

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UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis

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241-html.html

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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers

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Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis

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  DOI: 10.1016/j.neuron.2024.01.028
  
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