1,925 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Long noncoding RNA Gm4419 promotes mesangial cell proliferation and extracellular matrix accumulation via the miR-455-3p/histone deacetylase 2 axis
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    sciencedirect.com/science/article/pii/S2405844024148669
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    CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
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    sciencedirect.com/science/article/pii/S2211124724011483
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    Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC11433893/
  5. Sep 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGF12 Positively Regulates Keratinocyte Proliferation by Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11497104/
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    CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13736
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    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
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    Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation
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    academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae156/7721236
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    Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11417675/
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    Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
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    ncbi.nlm.nih.gov/pmc/articles/PMC11413390/
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    Invention of circRNA promoting RNA to specifically promote circRNA production
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    Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
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    C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes
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    sciencedirect.com/science/article/pii/S1097276524007330
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    MC4R Variants Modulate α-MSH and Setmelanotide Induced Cellular Signaling at Multiple Levels
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    ncbi.nlm.nih.gov/pmc/articles/PMC11403317/
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    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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    Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
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    Synergistic effects of PARP inhibition and cholesterol biosynthesis pathway modulation
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    Targeted degradation of specific TEAD paralogs by small molecule degraders
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    ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer
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    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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    Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer
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    Epigenetic alterations in bioaccumulators of cadmium: Lessons from mammalian kidneys and plants
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification
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    SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing
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  32. Aug 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts
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    Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
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    Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases
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    Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution
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    Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure
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    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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    A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
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    Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis
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    MMP9 drives ferroptosis by regulating GPX4 and iron signaling
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    Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies
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    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
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    A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
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    Biodegradable silica nanoparticles for efficient linear DNA gene delivery
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    Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis | EMBO reports
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    SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia
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    PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1
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    Subcellular Redox Responses Reveal Different Cu-dependent Antioxidant Defenses between Mitochondria and Cytosol
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  54. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
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    Adeno-Associated Vector-Delivered CRISPR/SaCas9 System Reduces Feline Leukemia Virus Production In Vitro
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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  57. pubs.acs.org pubs.acs.org
    Petrol Note in Riesling – 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) Selectively Activates Human Odorant Receptor OR8H1
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    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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  59. Jul 2024
  60. www.sciencedirect.com www.sciencedirect.com
    Application of bioluminescence resonance energy transfer assays in primary mouse neuronal cultures
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    Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis
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    Presymptomatic Targeted Circuit Manipulation for Ameliorating Huntington’s Disease Pathogenesis
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    ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome
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    Structural insights into an atypical histone binding mechanism by a PHD finger
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis
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    ‘Radical’ differences between two FLIM microscopes affect interpretation of cell signaling dynamics
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    MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway
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    Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling
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    SART3 reads methylarginine-marked glycine- and arginine-rich motifs
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    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma
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    Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – implications for transmitter co-release from dopamine neurons
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    Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution
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    A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state
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    ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins
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    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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    Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
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    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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    Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
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  89. journals.asm.org journals.asm.org
    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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  90. Jun 2024
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  181. www.sciencedirect.com www.sciencedirect.com
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  182. www.nature.com www.nature.com
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  186. 52.53.155.43 52.53.155.43
    The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2
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  187. Feb 2024
  188. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
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    Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment
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  190. www.jneurosci.org www.jneurosci.org
    EHBP1 is critically involved in dendritic arbor formation and is coupled to factors promoting actin filament formation
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  191. aacrjournals.org aacrjournals.org
    A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models
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    Bioluminescence Imaging Reveals Enhanced SARS-CoV-2 Clearance in Mice with Combinatorial Regimens
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