for - answer - Denis Noble - to Michael Levin - question - What percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards ? - a very large fraction is epigenetic inheritance indeed.

for - question - Michael Levin to - Denis Noble - percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards

for - evolution - work to identify non-DNA information passed down to germ line - millions of permutations - fluorescence technique applied to only a few at a time - tedious work - Denis Noble

for - evolution - epigenetic AND new DNA can BOTH be incorporated into the germ line - Denis Noble

for - evolution - viruses and other organisms - inject information into germ line throughout evolution - Denis Noble

for - evolutionary biology - Weissman barrier - refuted by modern research - Denis Noble

for - Weismann Barrier - disputed by Darwin himself, who believed that the body sends information to the germ line to pass on to the next generation - Denis Noble

for - quote - DNA simply does not replicate like a crystal. You have to have a living organism to enable it to do so. - Denis Noble

for - quote - myth - Richard Dawkin myth - recreate entire organism from DNA - not possible - Denis Noble

quote - myth - Richard Dawkin myth - recreate entire organism from DNA - not possible - Denis Noble - (see below) - As Richard Dawkins told me two years ago in a debate with him: - "Denis, we could inscribe your DNA in blocks of granite, - the C's G's A's and T's, - and we' keep those blocks of granite for 10,000 years and then we'll be able to recreate you." - I said no you can't - why not? - Well, where would you get my mother's egg cell, as it was in1936 - Well you can see that the point here, it led people to a very simplistic idea that from DNA you could automatically recreate a person, an organism exactly as it is in its first, Incarnation if you like - We can all be reincarnated as many times as we wish!<br /> - Well, one one might sort of wish to be a bit of a Buddhist in all of this and get away with that, - but I don't think even the Buddhists would accept that that was the way they were going to do it if they do it at all

for - DNA replication accuracy - 1 in 10,000 - too high for successful replication - another higher level mechanism to correct for these errors - need a whole body for that - Denis Noble

for - Systems perspective - integrate reductionism with global properties - Denis Noble - multi scale competency architecture - Denis Noble - adjacency - multi-scale competency architecture - Michael Levin - Denis Noble advocates for

adjacency - between - multi-scale competency architecture - Michael Levin - Denis Noble advocates for - adjacency relationship - Michael's multi-scale competency architecture is another way to sum up what Denis is saying

for - quote - Hodgkin cycle - example of connection between global property and molecular properties - Denis Noble

for - evolutionary biology - Denis Noble - journey from reductionist to non-reductionist - ion channel and cell membrane work - connects to bioelectricity in the entire body

for - book - Dance to the Tune of Life - Denis Noble

for - from - Denis Noble - Michael Levin interview

from - Denis Noble - Michael Levin interview - https://hyp.is/W2sK1qilEe-9MKdyybb_oA/www.youtube.com/watch?v=AJjIlu9tem8

for - critique of - Gene Centricity - Denis Noble

from - youtube -Evolution 2 Podcast Interview - Denis Noble - Book - Understanding Living Systems - https://hyp.is/-EuWvBYHEe-t9xtn9h1dhA/docdrop.org/video/oHZI1zZ_BhY/

for - health advice - aging well - Denis Noble

health advice - aging well - ll if you want to age well do something! - It can be - dancing - music - swimming - whatever but do something - That's the first bit of advice to those who want to make sure that they stay on top

for - progress trap - genetic engineering - Denis Noble

for - Denis Noble - Ready Noble - evolutionary biology - critique of Richard Dawkins Selfish Gene theory - critique of gene centrism - book - Understanding Living Systems - human agency

summary - In this informative interview, brothers Denis and Ray Noble discuss their new book - Understanding Living Systems, and - dispel the 70 year old narrative of Gene centrism and the selfish gene as determining the high level behaviour of living organisms

for - recombination of proteins in higher level proteins - from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble

from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble - https://hyp.is/OttWABYFEe--gLNFyeNyTw/docdrop.org/video/oHZI1zZ_BhY/

for - Oded Rechavi - neurobiology - gene centrism - critique - from - youtube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble

summary - Rechavi performed experiments with C Elegan and demonstrated that it possesses a type of neuron that - produces RNA that in response to elevated temperature change is transmitted to reproductive cells so that the offsprings encode it in the genome, and it is better adapted to deal with elevated temperatures

question - How many species do this? Is it generally found throughout nature?

from - outube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble - https://hyp.is/OUlGVBXrEe-iaBeZhH_4DQ/docdrop.org/video/oHZI1zZ_BhY/

for - quote - reductionism has failed - Denis Noble

for - follow up - paper - Could physiology rescue genomics?

to - Could physiology rescue genomics? - https://hyp.is/bslQ-BVVEe-hgF-rrNmjrA/academic.oup.com/biolinnean/article/139/4/357/6604006

for - adjacency - progress trap - Crispr - gene therapy - Denis Noble - human genome project

adjacency - between - human genome project - gene therapy - Crispr - progress trap - adjacency relationship - The idea that we can find specific causal relationships between genes and disease and use gene therapy to cure disease, - an envisioned goal of the human genome project - can be very dangerous because - usually one gene collaborates with many other genes to bring about an effect - If we don't know all the relationships, we can bring about a progress trap

for - comparison - human vs AI robot - Denis Noble

for - quote - Darwin would never have been a Neo-Darwinian - Denis Noble

for - metaphor - genes - musical scores - Denis Noble

for - quote - being wrong - Denis Noble

quote - Being wrong - Denis Noble - If we didn't have people who were wrong - we wouldn't be where we are

for - physiology rescues evolutionary biology - Denis Noble

from - youtube - IAI interview - Why Dawkins is Wrong - Denis Noble

for - paper - Physiology restores purpose to evolutionary biology - Denis Noble - Raymond Noble - year - 2023

from - youtube - IAI interview - Why Dawkins is wrong - Denis Noble - https://hyp.is/eqKOYhVVEe-XVKuwMtOTTg/docdrop.org/video/dCLRKP9NW8I/

for - molecular biology - paradigm shift - living system - 4 common misunderstandings - book - Understanding Living Systems - 4 common misunderstandings

4 common misunderstandings of living systems - 1. The central dogma of molecular biology - one way causation - Genes (DNA) to - proteins to - organism - 2. The Weismann Barrier - 3. DNA as self-replicator - 4. Separation of Replicator (DNA) and Vehicle (Living cell) are completely separate

for - quote - Denis Noble - quote - baby not born selfish

for - book - Biology Beyond the Genome - author - scientist - biologist - Denis Noble - book - Understanding Living Systems

for - Keith Baverstock - paper - The Gene and Appraisal

from - youtube - Biology Beyond the Gene - Denis Noble - https://hyp.is/UrvwdhVDEe-QWrPAx9y1aw/docdrop.org/video/bzXFSufDDn8/