3 Matching Annotations
- Nov 2023
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www-nature-com.ezproxy.rice.edu www-nature-com.ezproxy.rice.edu
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triggering homologous recombination and creating genetic instability10,11,12,13
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- Jan 2021
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www-pnas-org.ezproxy.rice.edu www-pnas-org.ezproxy.rice.edu
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Aminimumof%20basepairsinacompletelyhomologoussegmentisrequiredforsignificantrecombination.Thereisanexponentialincreaseinthefre-quencyofrecombinationwhenthelengthofhomologousDNAisincreasedfrom20basepairsto74basepairsandanapparentlylinearincreasewithlongerDNAsegments.Mis-matcheswithinahomologoussegmentcandramaticallyde-creasethefrequencyofrecombination.
A minimum of 20 base pairs in a completely homologous segment is required for significant recombination. There is an exponential increase in the frequency of recombination when the length of homology increases from 20 to 74 bp and an apparently linear increase with longer DNA segments. Mismatches within a homologous segment can dramatically decrease the frequency of recombination.
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- Mar 2020
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www-nature-com.ezproxy.rice.edu www-nature-com.ezproxy.rice.edu
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In E. coli, homologous recombination occurs most frequently when there is a contiguous stretch of sequence >25 bp
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