Disorder studied: Type 1 von Willebrand disease (T1-VWD).

Type of study: Translational

Model organism: Mouse (inbred strains) Obtained from Jackson Laboratory

Analyses:

VWF plasma protein quantitation (ELISA)

Hertiability calculations

PCR genotyping

QTL analysis

Allele-specific primer extension analysis

Results:

Identified new modifier of VWF known as (Mvwf5). Also found two loci unliked to Vwf known as (Mvwf6-7)

Mice with this variant displayed statistically significant decrease in VWF levels, recapitulating the decreasing patterns displayed in humans.

However, another strain of inbred mice with a different mutation did not show an age-dependent decrease in VWF. Suggests strain-specific differences in regulation of VWF levels over time.

Mvwf5 is a cis-regulatory variant altering Vwf mRNA expression.

This is a natural variant of the Vwf allele among inbred strains of mice. Found this variant causes elevation in steady-state levels of Vwf mRNA.

Authors state findings show equivalent of of type 1 VWD is remarkably common in mice and humans. ALso state the Mvwf1 analysis in wild mouse populations suggest this locus is under selective pressure.

Of the 5 potential modifier loci identified, 3 display conservation of synteny with potential human modifier loci.

this suggests that perhaps the failure of the COP meetings may be partially due to focusing at the wrong level and demographics. the top 1 and 10 % live in every country. A focus on the wealthy class is not a focus area of COP negotiations perse. Interventions targeting this demographic may be better suited at the scale of individuals or civil society.

Many studies show there are no extra gains in happiness beyond a certain point of material wealth, and point to the harmful impacts of wealth accumulation, known as affluenza, and show many health effects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950124/, https://theswaddle.com/how-money-affects-rich-people/, https://www.marketwatch.com/story/the-dark-reasons-so-many-rich-people-are-miserable-human-beings-2018-02-22, https://www.nbcnews.com/better/pop-culture/why-wealthy-people-may-be-less-successful-love-ncna837306, https://www.apa.org/research/action/speaking-of-psychology/affluence,

A Human Inner Transformation approach based on an open source praxis called Deep Humanity is one example of helping to transform affluenza and leveraging it accelerate transition.

Homi Bhabha is an academician who is currently the Director of the Humanities Center at Harvard University as well as the Anne F. Rothenberg Professor of English and American Literature and Language. He is a significant figure in the contemporary post-colonial studies and had contributed key ideas to the school such as Third-space, Hybridity, Ambivalence, and Mimicry to name a few.

Short Answer: A football (or as Americans like to say, soccer) player.

Long Answer: Born in Marseille, France to Algerian immigrants, Zidane is most well known for being a three-time FIFA World Player of the Year who led France to victory in the 1998 World Cup. He has played for clubs in France, Italy and Spain, but his career ended when he was expelled from the 2006 World Cup final for headbutting an opponent.

Rather than saying the relief is what makes the situation humorous, I would be more willing to believe that the humour makes me feel more relieved about the situation.

Or maybe seeing something unexpected would cause you to be relief, and because you're not as tense as before, you're able to laugh and see the humour in it?

So in other words, a situation is humorous if it evokes conflicting emotions within the person viewing it.

Key and Peele - I do feel conflicted about this sketch because on one hand, it's a serious and pertinent problem in reality as the sombre tone of the first few seconds of the sketch conveyed while it was still being pretty normal. However, as it continued on, it got increasingly interrupted by amateur magic tricks by the cop, who also had the most hilarious impressions thanks to Key, that did make me want to laugh. However, I felt that I shouldn't laugh - this conflicting emotions just make me feel guilty, not humorous. Am I misinterpreting this category?

Because she just won the Olympics final and since - very uderstandably - it is an amazing and wonderful accomplishment, she danced in this manner to express her joy in celebration.

The way the act was described covers a layer of deliberate prejudice over her actions, however. "...Crip-Walking all over.." implies a certain amount of chaos or scene being made when in reality, it barely lasted a few seconds, contained within her little spot at her side of the court. And watching her move like that with a huge smile on her face, as well as her sister's, anyone would be hard pressed or extremely biased to interpret this action as anything other than just an automatic reaction borne out of happiness and joy.

I think it refers to when someone makes fun of certain characteristics or features of another person with the intent to tease or amuse but without any malicious intentions. By this I mean, they did not do it to hurt the other, or would/should not have done it if they knew it would've hurt the person they were mocking regardless of it giving others enjoyment.

Does she mean the western civilization? That she would not have been part of the USA as she was then had it not been for slavery?

They were protective of her, then? They cared for her in a more sincere way separate from the superficial way the whites treated her despite the treatment being more "positive" towards her "joyful tendencies".

I wonder why though - is it because they felt the coloredness clearly and constantly unlike Zora and therefore could not share the joy she freely did in her childlike innocence?

I wonder what about the exchanges were queer to her. Did they compliment each other out of politeness about things they didn't really mean, which struck her, even as a young child, to be strange?

The instructions above used this as an example of how Zora Neale Hurston was not ashamed to be colored when to me, I interpreted it as her highlighting some sort of shortcoming on her part at that point of time that didn't make her "colored-ness" less severe.

The saddest and scariest thing to me about these hate crimes is that it has all to do with something beyond your own control. The perpetrators hate you, hurt you not for something you have done or can do, but rather for the sake of you simply being you. I can only imagine how much worse it would be for those who actually have experienced it and have this threat looming over them every day. It's unbelievably scary to me that we live in a world - no, a society - like this. But perhaps we can be empowered by the the fact that the fault lies in the beliefs and norms we have built around ourselves when it comes to race, and not something that is set in stone. I believe this means that we still have the power to turn these assumptions and harmful stereotypes around.