for - interview - Michael Levin - Dennis Noble D 4 min Hodgkin cycle ion channels and global properties of cell voltage work together - multi level approach

Heart organ constrains molecular level functions

Neo Darwinism is not a good model Dna cannot self replicate itself like a crystal as Schroedinger thought, it needs a cell to do it

M ?

D Many viruses have introduced properties into our germ line

Have to take into account epigenetic inheritance

Fluorescent labels to identify molecules in vesicles to identify which molecules are passed down to the germ line

There are millions of potential molecules but the fluorescence technique can only follow 4 or 5 if these

M ? What is your guess of % of genetic Vs epi-genetic contribution to germ line?

D Difficult to say Epigenetic must contribute large fraction to cell differentiation Digital information - from 3 billion DNA base pairs Analog information - exceeds DNA base pairs

Paddington - introduced the term epigenetic in the 50s

Exercising tells cells to grow more proteins It's ubiquitous

Life is the creator of life Life can alter DNA all the time - ie immune system is doing it all the time Life can alter what it's physiologically doing Life does have purpose /intention Many standard texts rule out of court certain ideas is.Lamark is disallowed Lamark and Darwin did not disagree

John Maynard Smith, an engineer by trade wrote The Theory of Evolution to teach himself evolution

He never accepted Wiseman Barrier Evolution textbooks need to be rewritten

M? What off the one thing that needs to change?

D Re write texts books