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  1. May 2023
    1. iron-bearing transferrin interacts with its receptor
      1. Iron is transported in the blood by the iron-transferrin complex.
      2. The complex interacts with specific transferrin receptors on the surface of cells that express transferrin receptors, such as developing erythroblast cells.
      3. The iron-bearing transferrin is internalized via clathrin-coated pits and transported to an acidic endosome.
      4. Iron is released from the transferrin at the low pH of the endosome.
      5. Iron is made available for heme synthesis.
      6. The transferrin-receptor complex is recycled to the surface of the cell.
      7. The bulk of the transferrin is released back into circulation, and the transferrin receptor re-anchors into the cell membrane.
      8. Iron in excess of the amount needed for hemoglobin synthesis binds to a storage protein, apoferritin, forming ferritin.
      9. Senescent red cells are recognized by the cells of the reticuloendothelial system and undergo phagocytosis.
      10. Hemoglobin is broken down, and the iron is shuttled back to the surface of the RE cell.
      11. Iron is presented to circulating transferrin via the iron export channel, ferroportin.
      12. Iron is then available for reutilization for hemoglobin synthesis