Aortic dissection typically presents acutely with sudden, severe tearing chest or back pain, often described as lancinating in quality. [5-6] Approximately 50% of patients with thoracic aortic aneurysm may progress to dissection without timely intervention. [5] In contrast, thoracic aortic aneurysm is usually asymptomatic and discovered incidentally during physical examination or imaging for other indications. [5]
9 Matching Annotations
- Mar 2026
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accessmedicine.mhmedical.com accessmedicine.mhmedical.com
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- Recent evidence suggests that inflammatory biomarkers may aid differentiation. The neutrophil-to-lymphocyte ratio (NLR) shows high diagnostic accuracy for distinguishing dissection from controls (AUC 0.933), while the fibrinogen-to-d-dimer ratio best differentiates dissection from aneurysm (AUC 0.898, sensitivity 77%, specificity 84%). [10] D-dimer levels below 500 ng/mL make acute aortic syndrome unlikely in low-risk patients
- CT angiography is the imaging modality of choice for differentiating these conditions in the emergency setting, with very high sensitivity and specificity for acute aortic syndromes
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- Jan 2025
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bmcmedresmethodol.biomedcentral.com bmcmedresmethodol.biomedcentral.com
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The performance of a marker is evaluated by the area under the ROC curve (AUC) in which a higher AUC value indicates a better marker performance. The AUC is also equal to the probability of a diseased individual having a higher marker value than a healthy individual [8].
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academic.oup.com academic.oup.com
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The goal of this article is to propose a new direct method that provides straightforward inference for AUC(t) and IAUC. Our method directly models AUC(t) as a function of time t using a flexible and yet parsimonious parametric model, namely, the fractional polynomials model proposed by Royston and Altman (1994).
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For the purpose of estimating the time‐dependent AUC and IAUC, the “indirect” methods have some drawbacks. For example, most ROC‐estimation procedures rely on strong parametric assumptions such as proportional hazards, which may lead to potential bias due to the misspecification of the time‐to‐event model. In addition, because these methods are “indirect,” they are not particularly efficient and require unnecessary intensive computation.
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everal time‐dependent measures have been proposed in the literature, including time‐dependent sensitivity, specificity, ROC and AUC (Heagerty, Lumley, and Pepe, 2005; Heagerty and Zheng, 2005).
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- Feb 2019
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www.auccaravan.com www.auccaravan.com
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student union group kind of took it over
See the February 11, 2019 article in The Caravan about the Student Union (SU's) lunch presentation which preceded the AUC Board of Trustees (BoT) letter of support for the AUC president.
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the vote of no confidence
See the February 10, 2019 article in The Caravan about the AUC University Senate's 80% vote of no confidence in the AUC president and his administration.
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Faculty Handbook
Here is a link to the 2015-16 AUC Faculty Handbook.pdf).
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Professor Sean McMahon?
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