sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED.
These are the effects I was expecting to find. cGMP plays a role in SCN nighttime signalling, though I expect it has other mechanisms as well.
In severe OSA, the use of sildenafil 50mg at bedtime plays a detrimental role on respiratory parameters
This is probably due to nasal congestion.
Conclusion: Our data suggest that the combination of VLF with morphine may be a relevant therapeutic implication to manage pain even when tolerance to morphine exists. Moreover, our data demonstrates the involvement of L-Arg/NO/cGMP pathway in the prevention of morphine tolerance and dependence by venlafaxine.
It's not clear if this has relevance to the subjective effects. I'm starting to think that I won't get an answer anytime soon.
Results: The administration of sildenafi l reduced all of the morphine withdrawal symptoms.
An acute effect. Interesting but not particularly consequential. It does mean, however, that I need to be wary of studies using withdrawal as a netric when combining PDE5 inhibitors with opioids.