133 Matching Annotations
  1. Last 7 days
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    Characterising replisome disassembly in human cells
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    1. scibot 19 Jul 2024
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    sciencedirect.com/science/article/pii/S2589004224014858
  3. Jun 2024
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1534580724003277
  5. May 2024
  6. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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    1. scibot 16 May 2024
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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    sciencedirect.com/science/article/pii/S2211124724005333
  8. Apr 2024
  9. aacrjournals.org aacrjournals.org
    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-1459

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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
    2
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      DOI: 10.1016/j.celrep.2024.114116

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    sciencedirect.com/science/article/pii/S2211124724004443
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    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
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    embopress.org/doi/full/10.1038/s44318-024-00043-2
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    sciencedirect.com/science/article/pii/S2211124724003929
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
    1. scibot 02 Apr 2024
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    sciencedirect.com/science/article/pii/S0092867424002502
  16. Mar 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    1. scibot 29 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001758
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    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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    1. scibot 06 Mar 2024
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  19. Feb 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
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      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    sciencedirect.com/science/article/pii/S1097276524000546
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
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    sciencedirect.com/science/article/pii/S1568786424000223
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
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    sciencedirect.com/science/article/pii/S2211124724001062
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    A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
    2
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      DOI: 10.1038/s41698-024-00500-5

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    link.springer.com/article/10.1038/s41698-024-00500-5
  25. Jan 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
    1
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      DOI: 10.1016/j.isci.2023.108655

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    ncbi.nlm.nih.gov/pmc/articles/PMC10783591/
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    Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis
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    sciencedirect.com/science/article/pii/S0889159124000059
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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      DOI: 10.1016/j.devcel.2023.12.002

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    sciencedirect.com/science/article/pii/S1534580723006524
  29. Dec 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe
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      DOI: 10.1158/2767-9764.CRC-23-0306

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    ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
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    Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line
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    1. scibot 23 Dec 2023
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      DOI: 10.1016/j.isci.2023.108678

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    sciencedirect.com/science/article/pii/S2589004223027554
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113523

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    sciencedirect.com/science/article/pii/S2211124723015358
  33. Nov 2023
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    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
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      DOI: 10.1016/j.celrep.2023.113307

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    sciencedirect.com/science/article/pii/S2211124723013190
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Social withdrawal and anxiety-like behavior have an impact on zebrafish adult neurogenesis
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      DOI: 10.3389/fnbeh.2023.1244075

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    ncbi.nlm.nih.gov/pmc/articles/PMC10614005/
  36. Oct 2023
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    sciencedirect.com/science/article/pii/S1550413123003716
  38. Sep 2023
  39. 52.53.155.43 52.53.155.43
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  40. Aug 2023
  41. www.nature.com www.nature.com
    Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
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      DOI: 10.1038/s41467-023-39873-9

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    nature.com/articles/s41467-023-39873-9
  42. Jul 2023
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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  44. Jun 2023
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    FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
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      DOI: 10.1016/j.celrep.2023.112668

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    sciencedirect.com/science/article/pii/S2211124723006794
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    sciencedirect.com/science/article/pii/S2589004223010283
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    Centromere/kinetochore is assembled through CENP-C oligomerization
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    sciencedirect.com/science/article/pii/S1097276523003799
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    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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      DOI: 10.1016/j.molcel.2023.05.015

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    sciencedirect.com/science/article/pii/S1097276523003714
  49. May 2023
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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      DOI: 10.1016/j.celrep.2023.112484

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    Developmental switch in the function of inhibitory commissural V0d interneurons in zebrafish
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      DOI: 10.1016/j.cub.2022.06.059

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    sciencedirect.com/science/article/pii/S0960982222010211
  52. Apr 2023
  53. www.science.org www.science.org
    Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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  56. Mar 2023
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
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  59. Feb 2023
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    A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs
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    GEN1 promotes common fragile site expression
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  62. Jan 2023
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    MDC1 maintains active elongation complexes of RNA polymerase II
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  66. Dec 2022
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    Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
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    POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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  69. Nov 2022
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    Metabolic regulation by p53 prevents R-loop-associated genomic instability
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    Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
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  73. Oct 2022
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    BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
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  75. Sep 2022
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    DNA-PKcs promotes fork reversal and chemoresistance
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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    Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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  82. Jul 2022
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    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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    Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions
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  88. May 2022
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
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  94. Mar 2022
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  96. Feb 2022
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    Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
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  101. Nov 2021
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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  112. Jul 2021
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    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
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    EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
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  120. May 2021
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  128. Feb 2021
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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  132. Jan 2021
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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  135. Dec 2020
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    TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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  139. Nov 2020
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    Essentiality of CENP-A Depends on Its Binding Mode to HJURP
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  141. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance
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  142. Oct 2020
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    Heterogeneity of the Endocannabinoid System Between Cerebral Cortex and Spinal Cord Oligodendrocytes
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  144. Sep 2020
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    HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation
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  146. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
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    EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
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    Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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  150. Jan 2020
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    Na + /H + exchanger isoform 1 activity in AQP2-expressing cells can be either proliferative or anti-proliferative depending on extracellular pH
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    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development
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    GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis
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  157. Nov 2018
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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers
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    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
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    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance
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    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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    Eye Absence Does Not Regulate Planarian Stem Cells during Eye Regeneration
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    Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
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