165 Matching Annotations
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    A Quantitative DNA Fiber Assay to Monitor Replication Fork Progression, Protection, and Restart
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    pmc.ncbi.nlm.nih.gov/articles/PMC12887872/
  3. Feb 2026
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    Targeting ATR signaling in sarcoma with homologous recombination deficiency
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    sciencedirect.com/science/article/pii/S0304383526000637
  5. Dec 2025
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    Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
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    sciencedirect.com:5037/science/article/pii/S1097276525009360
  7. Nov 2025
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    H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623888/
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    KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
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    sciencedirect.com/science/article/pii/S2211124725012860
  10. Oct 2025
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    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
  13. Sep 2025
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    RAD51 is chromatin enriched and targetable in BRCA1-deficient cells
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  15. Aug 2025
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    PARP inhibitors potentiate proton therapy end-of-range effects by accelerating replication forks and promoting transcription conflict
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    RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331980/
  19. Jul 2025
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    Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases
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  21. Jun 2025
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    The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
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  23. Apr 2025
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    ASCL1 protein domains with distinct functions in neuronal differentiation and subtype specification
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    Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis
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  26. Dec 2024
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    Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells
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  31. Oct 2024
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    Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts
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  33. Sep 2024
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    Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia
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  35. Aug 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
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    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
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    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
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  39. Jul 2024
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    Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
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  43. May 2024
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    Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
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    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
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  46. Apr 2024
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    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
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  49. Mar 2024
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    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  51. Feb 2024
  52. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    DNA combing versus DNA spreading and the separation of sister chromatids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
  55. Jan 2024
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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  58. Dec 2023
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    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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  63. Nov 2023
  64. link.springer.com link.springer.com
    Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli
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    link.springer.com/article/10.1007/s12035-023-03746-5
  65. Oct 2023
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    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  68. Aug 2023
  69. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    science.org/doi/10.1126/science.adi3448
  70. www.biorxiv.org www.biorxiv.org
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1
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    sciencedirect.com/science/article/abs/pii/S1097276523005154
  72. Jun 2023
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    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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  74. May 2023
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    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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    science.org/doi/10.1126/sciadv.add8023
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    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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  77. www.biorxiv.org www.biorxiv.org
    DNA Combing versus DNA Spreading and the Separation of Sister Chromatids
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    biorxiv.org/content/10.1101/2023.05.02.539129v1
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    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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  79. Apr 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
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    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    science.org/doi/10.1126/sciadv.ade7997
  82. Jan 2023
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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  84. Dec 2022
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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    science.org/doi/10.1126/sciadv.abq0648
  87. Nov 2022
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    sciencedirect.com/science/article/pii/S2211124722015443
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    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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  91. Jul 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow
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    Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex
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    link.springer.com/article/10.1007/s12035-022-02936-x
  94. May 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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  96. Mar 2022
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    PTENα regulates endocytosis and modulates olfactory function
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201900588RR
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    Partial p53 reactivation is sufficient to induce cancer regression
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    link.springer.com/article/10.1186/s13046-022-02269-6
  99. Jan 2022
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    Adaptive differentiation promotes intestinal villus recovery
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    sciencedirect.com/science/article/abs/pii/S1534580721010327
  102. Dec 2021
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
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    ncbi.nlm.nih.gov/pmc/articles/PMC8668188/
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    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  106. Nov 2021
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC8565929/
  108. Oct 2021
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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  112. Sep 2021
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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  115. Aug 2021
  116. www.frontiersin.org www.frontiersin.org
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    PTENα regulates endocytosis and modulates olfactory function
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  120. Jul 2021
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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