148 Matching Annotations
  1. Last 7 days
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    sciencedirect.com/science/article/pii/S1097276524009894
  3. Dec 2024
  4. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
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    Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells
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    1. scibot 12 Dec 2024
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    sciencedirect.com/science/article/pii/S153458072400697X
  6. Oct 2024
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    Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts
    1
    1. scibot 09 Oct 2024
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    sciencedirect.com/science/article/pii/S1097276524007767
  8. Sep 2024
  9. www.jneurosci.org www.jneurosci.org
    Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia
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    1. scibot 25 Sep 2024
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      DOI: 10.1523/JNEUROSCI.2724-18.2019

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    jneurosci.org/content/39/29/5794
  10. Aug 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
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    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
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    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
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    sciencedirect.com/science/article/pii/S2211124724009239
  14. Jul 2024
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    Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation
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    sciencedirect.com/science/article/pii/S0021925824019938
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    sciencedirect.com/science/article/pii/S2211124724007939
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
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    1. scibot 05 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11219039/
  18. May 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
    1
    1. scibot 17 May 2024
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      DOI: 10.3389/fncel.2024.1396780

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    ncbi.nlm.nih.gov/pmc/articles/PMC11091264/
  20. 52.53.155.43 52.53.155.43
    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
    1
    1. scibot 10 May 2024
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  21. Apr 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
    1
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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
  24. Mar 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  26. Feb 2024
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    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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      DOI: 10.1158/1078-0432.CCR-23-2005

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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  28. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
    1. scibot 23 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001736
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA combing versus DNA spreading and the separation of sister chromatids
    2
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      DOI: 10.1083/jcb.202305082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
  30. Jan 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
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    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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    sciencedirect.com/science/article/pii/S1097276523010717
  33. Dec 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    sciencedirect.com/science/article/pii/S009286742301276X
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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      DOI: 10.7554/eLife.91263

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    ncbi.nlm.nih.gov/pmc/articles/PMC10712957/
  37. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
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    52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
  38. Nov 2023
  39. link.springer.com link.springer.com
    Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli
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      DOI: 10.1007/s12035-023-03746-5

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    link.springer.com/article/10.1007/s12035-023-03746-5
  40. Oct 2023
  41. www.sciencedirect.com www.sciencedirect.com
    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    sciencedirect.com/science/article/pii/S2589004223021806
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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      DOI: 10.1016/j.celrep.2023.112845

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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  43. Aug 2023
  44. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    science.org/doi/10.1126/science.adi3448
  45. www.biorxiv.org www.biorxiv.org
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    biorxiv.org/content/10.1101/2023.08.21.554173v1
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    Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1
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    sciencedirect.com/science/article/abs/pii/S1097276523005154
  47. Jun 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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    sciencedirect.com/science/article/pii/S1097276523003829
  49. May 2023
  50. www.science.org www.science.org
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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      DOI: 10.1126/sciadv.add8023

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    science.org/doi/10.1126/sciadv.add8023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10171824/
  52. www.biorxiv.org www.biorxiv.org
    DNA Combing versus DNA Spreading and the Separation of Sister Chromatids
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      DOI: 10.1101/2023.05.02.539129

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    biorxiv.org/content/10.1101/2023.05.02.539129v1
  53. www.sciencedirect.com www.sciencedirect.com
    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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      DOI: 10.1016/j.cell.2022.06.028

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    sciencedirect.com/science/article/pii/S0092867422007802
  54. Apr 2023
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
    1
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      DOI: 10.1126/sciadv.ade7997

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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
  56. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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      DOI: 10.1126/sciadv.ade7997

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    science.org/doi/10.1126/sciadv.ade7997
  57. Jan 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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  59. Dec 2022
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    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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  61. www.science.org www.science.org
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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  62. Nov 2022
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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  66. Jul 2022
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    Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex
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  69. May 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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  71. Mar 2022
  72. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
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    Partial p53 reactivation is sufficient to induce cancer regression
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  74. Jan 2022
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    Adaptive differentiation promotes intestinal villus recovery
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  77. Dec 2021
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    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
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    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  81. Nov 2021
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    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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  83. Oct 2021
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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  87. Sep 2021
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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  90. Aug 2021
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    PTENα regulates endocytosis and modulates olfactory function
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  95. Jul 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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    The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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  105. Jun 2021
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    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
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  107. May 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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    Homology-directed repair protects the replicating genome from metabolic assaults
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  113. Feb 2021
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    Role of GnRH isoforms in paracrine/autocrine control of zebrafish ( Danio rerio ) spermatogenesis
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    DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
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    WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion
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    Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability
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    DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair
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    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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      Mouse monoclonal anti-BrdU

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    EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
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    Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
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  159. www.sciencedirect.com www.sciencedirect.com
    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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      DOI: 10.1016/j.celrep.2019.04.032

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      DOI: 10.1016/j.molcel.2019.01.001

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  162. Nov 2018
  163. www.nature.com www.nature.com
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    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection
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    BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
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    Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse
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    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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    Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2
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    Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity
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  174. Nov 2017
  175. www.sciencedirect.com www.sciencedirect.com
    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
    1
    1. scibot 08 Nov 2017
      Mouse anti-BrdU Clone B44BD Transduction LaboratoriesCat# 347580

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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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    Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells
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    Serotonergic Projections Govern Postnatal Neuroblast Migration
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    Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
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  180. elifesciences.org elifesciences.org
    Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice
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  181. www.jneurosci.org www.jneurosci.org
    In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two subunits of human ORC are dispensable for DNA replication and proliferation
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      AB_400326

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  183. www.sciencedirect.com www.sciencedirect.com
    Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord
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      AB_400326

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    sciencedirect.com/science/article/pii/S1044743116301579
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum
    1
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      AB_400326

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    ncbi.nlm.nih.gov/pmc/articles/PMC4157608/
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wls Provides a New Compartmental View of the Rhombic Lip in Mouse Cerebellar Development
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