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Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses

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1. scibot 23 Oct 2025
  
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  DOI: 10.1126/sciadv.adw4618
  
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science.org/doi/10.1126/sciadv.adw4618
Oct 2025
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Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses

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science.org/doi/10.1126/sciadv.adw4618
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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.drup.2025.101312
  
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sciencedirect.com/science/article/pii/S1368764625001153
Sep 2025
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RAD51 is chromatin enriched and targetable in BRCA1-deficient cells

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.017
  
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sciencedirect.com/science/article/pii/S1097276525007026
Aug 2025
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PARP inhibitors potentiate proton therapy end-of-range effects by accelerating replication forks and promoting transcription conflict

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1. scibot 28 Aug 2025
  
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  DOI: 10.1016/j.ijrobp.2025.08.049
  
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sciencedirect.com/science/article/pii/S0360301625061978
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2025.08.06.668996v1.full-html.html

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  DOI: 10.1101/2025.08.06.668996
  
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52.53.155.43/9762f0542a12c1b879bb3817e6abf20525e5b06e/2025.08.06.668996v1.full-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart

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  DOI: 10.1038/s44319-025-00497-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12331980/
Jul 2025
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Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases

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1. scibot 10 Jul 2025
  
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  DOI: 10.1038/s41419-025-07812-9
  
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nature.com/articles/s41419-025-07812-9
Jun 2025
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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.06.002
  
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sciencedirect.com/science/article/pii/S1097276525005027
Apr 2025
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ASCL1 protein domains with distinct functions in neuronal differentiation and subtype specification

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  DOI: 10.1016/j.ydbio.2025.04.001
  
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sciencedirect.com/science/article/pii/S0012160625000880
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Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.mcn.2025.104007
  
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sciencedirect.com/science/article/pii/S104474312500017X
Dec 2024
www.cell.com www.cell.com

Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

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1. scibot 28 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115093
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01444-X
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.034
  
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sciencedirect.com/science/article/pii/S1097276524009894
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CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation

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1. scibot 13 Dec 2024
  
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  DOI: 10.1093/nar/gkae1068
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
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Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.11.015
  
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sciencedirect.com/science/article/pii/S153458072400697X
Oct 2024
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Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.molcel.2024.09.020
  
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sciencedirect.com/science/article/pii/S1097276524007767
Sep 2024
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Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia

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1. scibot 25 Sep 2024
  
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  DOI: 10.1523/JNEUROSCI.2724-18.2019
  
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jneurosci.org/content/39/29/5794
Aug 2024
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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.07.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
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Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

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1. scibot 21 Aug 2024
  
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  DOI: 10.1038/s41388-024-03094-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
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RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114594
  
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sciencedirect.com/science/article/pii/S2211124724009239
Jul 2024
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Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.jbc.2024.107492
  
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sciencedirect.com/science/article/pii/S0021925824019938
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FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114464
  
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sciencedirect.com/science/article/pii/S2211124724007939
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CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

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1. scibot 05 Jul 2024
  
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  DOI: 10.7554/eLife.83712
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11219039/
May 2024
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Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats

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1. scibot 17 May 2024
  
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  DOI: 10.3389/fncel.2024.1396780
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11091264/
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Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells

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1. scibot 10 May 2024
  
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  DOI: 10.1101/2024.02.05.578390
  
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52.53.155.43/d52a41e1a3d17093378781ca7887483638d670e8/2024.02.05.578390.full-html.html
Apr 2024
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Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.04.004
  
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sciencedirect.com/science/article/pii/S109727652400282X
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BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks

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  DOI: 10.1016/j.celrep.2024.114006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
Mar 2024
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RTF2 controls replication repriming and ribonucleotide excision at the replisome

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1. scibot 06 Mar 2024
  
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  DOI: 10.1038/s41467-024-45947-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
Feb 2024
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A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients

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1. scibot 24 Feb 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-2005
  
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aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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  DOI: 10.1016/j.celrep.2024.113845
  
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sciencedirect.com/science/article/pii/S2211124724001736
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DNA combing versus DNA spreading and the separation of sister chromatids

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  DOI: 10.1083/jcb.202305082
  
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  DOI: 10.1083/jcb.202305082
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
Jan 2024
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In silico protein interaction screening uncovers DONSON’s role in replication initiation

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1. scibot 24 Jan 2024
  
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  DOI: 10.1126/science.adi3448
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
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BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair

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1. scibot 20 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.12.025
  
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sciencedirect.com/science/article/pii/S1097276523010717
Dec 2023
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.cell.2023.11.022
  
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sciencedirect.com/science/article/pii/S009286742301276X
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Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108564
  
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Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging

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ccr-23-2005-html.html

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Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli

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The splicing factor DHX38 enables retinal development through safeguarding genome integrity

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PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

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In silico protein interaction screening uncovers DONSON’s role in replication initiation

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Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging

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Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1

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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

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Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair

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Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair

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DNA Combing versus DNA Spreading and the Separation of Sister Chromatids

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Replication stress impairs chromosome segregation and preimplantation development in human embryos

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Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

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Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks

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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps

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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

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Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors

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Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow

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Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex

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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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PTENα regulates endocytosis and modulates olfactory function

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Partial p53 reactivation is sufficient to induce cancer regression

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WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

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Adaptive differentiation promotes intestinal villus recovery

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining

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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

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DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

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Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

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Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

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PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

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PTENα regulates endocytosis and modulates olfactory function

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Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

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Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

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ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response

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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

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Homology-directed repair protects the replicating genome from metabolic assaults

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CARM1 regulates replication fork speed and stress response by stimulating PARP1

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Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells

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Role of GnRH isoforms in paracrine/autocrine control of zebrafish ( Danio rerio ) spermatogenesis

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DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

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Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

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Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation

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ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA

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TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

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WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion

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BRCA1 Mutational Complementation Induces Synthetic Viability

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SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability

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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

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Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells

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DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

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p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

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Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

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Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

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EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators

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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1

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Regional differences in mitral cell development in mouse olfactory bulb

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Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation

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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

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Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

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Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

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The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

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Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

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Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates

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Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

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Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

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Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

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Nov 2017
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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

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Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells

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Serotonergic Projections Govern Postnatal Neuroblast Migration

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Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

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Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

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In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation

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Two subunits of human ORC are dispensable for DNA replication and proliferation

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Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord

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Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum

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Wls Provides a New Compartmental View of the Rhombic Lip in Mouse Cerebellar Development

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