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Aug 2025
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Synthesis and evaluation of cyclobut-3-ene-1,2-dione-3-hydrazones with benzothiazole moiety as novel anticancer agents inducing nonapoptotic oncosis-like cell death

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sciencedirect.com/science/article/pii/S0753332225005980
Jul 2025
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ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113117
  
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sciencedirect.com/science/article/pii/S2589004225013781
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The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts

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  DOI: 10.1016/j.ebiom.2025.105870
  
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sciencedirect.com/science/article/pii/S2352396425003147
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Protocol for detecting LDLR on the cell surface of primary mouse hepatocytes using cell-surface biotinylation

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xpro.2025.103977
  
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sciencedirect.com/science/article/pii/S2666166725003831
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Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors

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1. scibot 22 Jul 2025
  
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  DOI: 10.1126/sciadv.adw5228
  
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science.org/doi/10.1126/sciadv.adw5228
Jun 2025
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Knockout of the V-ATPase interacting protein Tldc2 in B-type kidney intercalated cells impairs urine alkalinization

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1. scibot 25 Jun 2025
  
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  DOI: 10.1152/ajprenal.00363.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12184088/
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Resolving neutrophils through genetic deletion of TRAM attenuate atherosclerosis pathogenesis

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.isci.2024.110097
  
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sciencedirect.com/science/article/pii/S2589004224013221
May 2025
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CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication

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1. scibot 20 May 2025
  
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  DOI: 10.1126/science.adi2421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11305671/
Feb 2025
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EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis

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1. scibot 27 Feb 2025
  
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sciencedirect.com/science/article/pii/S1550413125000191
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CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

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  DOI: 10.1016/j.celrep.2025.115312
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00083-X
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PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0211
  
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aacrjournals.org/mct/article/24/1/56/750662/PARP7-Inhibitors-and-AHR-Agonists-Act
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The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.017
  
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sciencedirect.com/science/article/pii/S1097276525000474
Jan 2025
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Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers

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1. scibot 08 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0484
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11701801/
Nov 2024
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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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1. scibot 07 Nov 2024
  
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  DOI: 10.4103/1673-5374.385313
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11467935/
Sep 2024
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Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.stem.2020.02.007
  
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sciencedirect.com/science/article/pii/S1934590920300606
Aug 2024
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Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function

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1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.chembiol.2024.07.017
  
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sciencedirect.com/science/article/pii/S2451945624003192
Jul 2024
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Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.neuron.2024.06.017
  
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sciencedirect.com/science/article/pii/S0896627324004525
Jun 2024
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The ribotoxic stress response drives UV-mediated cell death

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1. scibot 06 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.018
  
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sciencedirect.com/science/article/pii/S0092867424005270
May 2024
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

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1. scibot 07 May 2024
  
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sciencedirect.com/science/article/pii/S1074761324002115
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CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication

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1. scibot 03 May 2024
  
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  DOI: 10.1126/science.adi2421
  
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science.org/doi/10.1126/science.adi2421
Apr 2024
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The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection

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  DOI: 10.1016/j.bbadis.2024.167193
  
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Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

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1. scibot 10 Apr 2024
  
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  DOI: 10.7554/eLife.96891
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11001299/
Mar 2024
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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

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1. scibot 22 Mar 2024
  
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  DOI: 10.1038/s41467-024-46284-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
Nov 2023
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Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

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1. scibot 29 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108269
  
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Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.immuni.2023.09.013
  
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sciencedirect.com/science/article/pii/S1074761323004181
Oct 2023
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The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

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1. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.06.16.545259
  
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52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

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1. scibot 05 Oct 2023
  
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  DOI: 10.7554/eLife.85898
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10541180/
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ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation

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  DOI: 10.1016/j.isci.2023.107893
  
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sciencedirect.com/science/article/pii/S2589004223019703
Sep 2023
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Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113176
  
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  DOI: 10.1016/j.celrep.2023.113176
  
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sciencedirect.com/science/article/pii/S2211124723011889
Jul 2023
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
May 2023
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Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis

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1. scibot 17 May 2023
  
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  DOI: 10.1016/j.molcel.2023.03.023
  
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sciencedirect.com/science/article/pii/S1097276523002137
Apr 2023
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Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma

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1. scibot 29 Apr 2023
  
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  DOI: 10.1016/j.ygyno.2023.03.020
  
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sciencedirect.com/science/article/pii/S0090825823001671
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Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain

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1. scibot 12 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112353
  
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sciencedirect.com/science/article/pii/S2211124723003649
Mar 2023
europepmc.org europepmc.org

Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery

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1. scibot 16 Mar 2023
  
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  DOI: 10.1016/j.xcrm.2023.100976
  
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europepmc.org/article/med/36921598
Jan 2023
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SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis

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1. scibot 15 Jan 2023
  
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  DOI: 10.26508/lsa.202201457
  
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Olfactory Receptor OR2H1 is an effective target for CAR T cells in human epithelial tumors

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Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis

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MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice

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Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism

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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

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Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord

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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

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Efferocytosis induces macrophage proliferation to help resolve tissue injury

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GCN2 adapts protein synthesis to scavenging-dependent growth

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The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

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ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes

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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

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Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

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NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses

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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

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Live-cell imaging reveals kinetic determinants of quality control triggered by ribosome stalling

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Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

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Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

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Lactate Limits T Cell Proliferation via the NAD(H) Redox State

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TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity

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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

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EDF1 coordinates cellular responses to ribosome collisions

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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

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Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism

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Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice

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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

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HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development

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NYX‐2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR

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  DOI: 10.1111/jnc.14845
  
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Donepezil‐induced oligodendrocyte differentiation is mediated through estrogen receptors

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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

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High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

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Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation

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Decoding Transcriptome Dynamics of Genome-Encoded Polyadenylation and Autoregulation with Small-Molecule Modulators of Alternative Polyadenylation

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Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

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Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

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Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation

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USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels

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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

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A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms

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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

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Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation

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DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells

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Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation: Endocrinology: Vol 157, No 12

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