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Jul 2026
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LEF1 and niche factors determine T cell stemness across chronic diseases

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1. scibot 04 Jul 2026
  
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  DOI: 10.1016/j.cell.2026.06.022
  
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sciencedirect.com/science/article/pii/S0092867426007099
Jun 2026
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Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity

1
1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.immuni.2026.05.016
  
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sciencedirect.com/science/article/pii/S107476132600227X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling

1
1. scibot 10 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102769
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198297/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7

1
1. scibot 03 Jun 2026
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.celrep.2026.117204
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13222646/
Apr 2026
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Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches

1
1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.immuni.2026.03.023
  
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sciencedirect.com/science/article/pii/S1074761326001342
Mar 2026
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Decoding the spatiotemporal development of the blood-brain barrier in human cortex

1
1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.stem.2026.02.010
  
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sciencedirect.com/science/article/pii/S1934590926000809
Dec 2025
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Activated T cells degrade extracellular proteins to enhance effector functions

1
1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116797
  
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sciencedirect.com/science/article/pii/S2211124725015694
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

1
1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
Oct 2025
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The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

1
1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.immuni.2025.09.008
  
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sciencedirect.com/science/article/pii/S1074761325004194
Aug 2025
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Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy

1
1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102298
  
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sciencedirect.com/science/article/pii/S2666379125003714
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Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells

1
1. scibot 09 Aug 2025
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2025.07.018
  
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sciencedirect.com/science/article/pii/S1074761325003279
Jun 2025
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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

1
1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.025
  
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sciencedirect.com/science/article/pii/S1074761325002468
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma

1
1. scibot 17 Jun 2025
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.celrep.2025.115554
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166967/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 13 Jun 2025
  
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  DOI: 10.1158/1078-0432.ccr-25-0419
  
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52.53.155.43/095f1297dc44b7c13374b7a22bd6385cbe7ad75d/PDF-html.html
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Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.cell.2025.05.013
  
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sciencedirect.com/science/article/pii/S009286742500563X
Dec 2024
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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

1
1. scibot 10 Dec 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.xcrm.2024.101852
  
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sciencedirect.com/science/article/pii/S2666379124006232
Sep 2024
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Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2797631
  
  DOI: 10.1016/j.stem.2019.11.012
  
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sciencedirect.com/science/article/pii/S1934590919304679
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2019.09.013
  
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sciencedirect.com/science/article/pii/S1074761319304091
Jul 2024
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Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

1
1. scibot 25 Jul 2024
  
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  AB_2199302
  
  DOI: 10.1016/j.immuni.2024.06.014
  
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sciencedirect.com/science/article/pii/S1074761324003200
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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

1
1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.cmet.2024.06.006
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00231-6
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

1
1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

1
1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293343/
May 2024
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The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

1
1. scibot 23 May 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2024.04.026
  
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cell.com/immunity/fulltext/S1074-7613(24)00231-0
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Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade

1
1. scibot 03 May 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1158/1078-0432.CCR-23-1316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11061601/
52.53.155.43 52.53.155.43

Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma

1
1. scibot 02 May 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.isci.2024.109821
  
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52.53.155.43/90443b9a27af60bb323bc92daf2d7421a807e517/PIIS2589004224010435-html.html
Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

1
1. scibot 11 Apr 2024
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Mar 2024
www.cell.com www.cell.com

Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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1. scibot 15 Mar 2024
  
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  Cell Signaling TechnologyCat# 2203S
  
  DOI: 10.1016/j.cell.2024.02.022
  
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cell.com/cell/fulltext/S0092-8674(24)00224-1
Feb 2024
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RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis

2
1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113786
  
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2. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113786
  
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sciencedirect.com/science/article/pii/S2211124724001141
Jan 2024
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Inosine induces stemness features in CAR-T cells and enhances potency

1
1. scibot 26 Jan 2024
  
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  DOI: 10.1016/j.ccell.2024.01.002
  
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sciencedirect.com/science/article/pii/S1535610824000084
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miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.

1
1. scibot 18 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108650
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10788216/
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Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation

1
1. scibot 06 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.010
  
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sciencedirect.com/science/article/pii/S1550413123004618
Dec 2023
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Dihydroartemisinin inhibits the development of colorectal cancer by GSK-3β/TCF7/MMP9 pathway and synergies with capecitabine

1
1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.canlet.2023.216596
  
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sciencedirect.com/science/article/pii/S0304383523005475
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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113564
  
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sciencedirect.com/science/article/pii/S2211124723015760
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Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma

1
1. scibot 16 Dec 2023
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.ccell.2023.11.010
  
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sciencedirect.com/science/article/pii/S1535610823004014
Nov 2023
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Targeted perturbation of signaling-driven condensates

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  DOI: 10.1016/j.molcel.2023.10.023
  
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Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells

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Peritumoral Immune-suppressive Mechanisms Impede Intratumoral Lymphocyte Infiltration into Colorectal Cancer Liver versus Lung Metastases

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  DOI: 10.1158/2767-9764.CRC-23-0212
  
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Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

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May 2023
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Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox

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CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer

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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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Aug 2022
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SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells

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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

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Jul 2022
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Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

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Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution

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BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen

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Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts

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Apr 2022
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Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

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Mar 2022
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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

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CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels

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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

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PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure

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Aug 2021
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LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

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Jun 2021
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Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development

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May 2021
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Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

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  DOI: 10.1016/j.immuni.2020.09.005
  
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Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

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cell.com/immunity/fulltext/S1074-7613(21)00136-9
Apr 2021
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A unified atlas of CD8 T cell dysfunctional states in cancer and infection

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Mar 2021
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A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

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ncbi.nlm.nih.gov/pmc/articles/PMC7924951/
Feb 2021
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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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1. scibot 25 Feb 2021
  
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  RRID:AB_2199302
  
  DOI: 10.7554/eLife.61406
  
  Resource: (Cell Signaling Technology Cat# 2203, RRID:AB_2199302)
  
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elifesciences.org/articles/61406
Sep 2020
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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

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1. scibot 04 Sep 2020
  
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  Tcf1 (C63D9) rabbit mAb
  
  DOI: 10.1016/j.celrep.2020.03.048
  
  Resource: (Cell Signaling Technology Cat# 2203, RRID:AB_2199302)
  
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sciencedirect.com/science/article/pii/S2211124720303624
Jan 2020
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A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

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1. scibot 13 Jan 2020
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2019.06.023
  
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sciencedirect.com/science/article/pii/S1074761319302936
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Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

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1. scibot 13 Jan 2020
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.molcel.2019.08.016
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6898777/
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CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2019.10.009
  
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sciencedirect.com/science/article/pii/S1074761319304534
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Untitled document

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1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2199302
  
  DOI: 10.1016/j.immuni.2018.12.021
  
  Resource: (Cell Signaling Technology Cat# 2203, RRID:AB_2199302)
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1074761318305697
Nov 2018
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Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium

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1. scibot 05 Nov 2018
  
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  RRID:AB_2199302
  
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  (Cell Signaling Technology Cat# 2203, RRID:AB_2199302)
  
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Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

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1. scibot 05 Nov 2018
  
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  RRID:AB_2199302
  
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  (Cell Signaling Technology Cat# 2203, RRID:AB_2199302)
  
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