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Dual STING activation and CD47/SIRPα blockade via chitooligosaccharide-based nanoparticles to amplify antitumor immunity

1
1. scibot 13 Sep 2025
  
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  CVCL_7254
  
  DOI: 10.1016/j.jconrel.2025.114235
  
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sciencedirect.com/science/article/pii/S0168365925008478
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

1
1. scibot 07 Sep 2025
  
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  CVCL_7254
  
  DOI: 10.1158/2326-6066.CIR-25-0156
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402804/
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A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

1
1. scibot 07 Sep 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/0008-5472.CAN-24-0323
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875992/
Aug 2025
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Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

1
1. scibot 30 Aug 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.chom.2025.08.001
  
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sciencedirect.com/science/article/pii/S1931312825002975
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Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity

1
1. scibot 27 Aug 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1007/s00262-025-04111-2
  
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link.springer.com/article/10.1007/s00262-025-04111-2
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Lifespan-Regulated CAR-Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

1
1. scibot 27 Aug 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1002/advs.202417677
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202417677
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Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles

1
1. scibot 14 Aug 2025
  
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  RRID: CVCL_7254
  
  DOI: 10.1002/advs.202509208
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509208
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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

1
1. scibot 08 Aug 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.ccell.2025.07.006
  
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sciencedirect.com/science/article/pii/S1535610825003101
Jul 2025
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Tumor desialylation surpasses anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer

1
1. scibot 08 Jul 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1002/ijc.70031
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.70031
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A Pharmacokinetic and Pharmacodynamic Model of an IL-12 Anchored-Drug Conjugate for the Treatment of Solid Tumors

1
1. scibot 04 Jul 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/1535-7163.MCT-24-1051
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214881/
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Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect

1
1. scibot 02 Jul 2025
  
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  CVCL_7254
  
  DOI: 10.1136/jitc-2025-011487
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12211843/
Jun 2025
52.53.155.43 52.53.155.43

PDF-html.html

2
1. scibot 13 Jun 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/2159-8290.cd-24-1033
  
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2. scibot 11 Jun 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/2159-8290.cd-24-1033
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
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52.53.155.43/a7ee3b12d468dfb2dd9f5d25a6280eb2adf38466/PDF-html.html
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Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy

1
1. scibot 11 Jun 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1002/ijc.35472
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.35472
52.53.155.43 52.53.155.43

pdf-html.html

1
1. scibot 11 Jun 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/2326-6066.cir-24-0797
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
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52.53.155.43/714962b4df611138463d94a4796d134a4c0f1b27/pdf-html.html
May 2025
pubs.acs.org pubs.acs.org

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity

1
1. scibot 29 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1021/acs.jmedchem.5c00264
  
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pubs.acs.org/doi/10.1021/acs.jmedchem.5c00264
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering

1
1. scibot 28 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1136/jitc-2025-011524
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12097044/
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NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors

1
1. scibot 23 May 2025
  
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  RRID: CVCL_7254
  
  DOI: 10.1007/s00262-025-04079-z
  
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link.springer.com/article/10.1007/s00262-025-04079-z
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

1
1. scibot 20 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
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Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein

1
1. scibot 20 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1136/jitc-2024-010831
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12067867/
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Combination therapy with cetirizine and anti-PD-1 antibody suppresses colitis-induced colon tumor formation in mice

1
1. scibot 17 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.ejphar.2025.177704
  
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sciencedirect.com/science/article/pii/S0014299925004583
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Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer

1
1. scibot 16 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.bbadis.2025.167891
  
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sciencedirect.com/science/article/pii/S092544392500239X
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The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

1
1. scibot 16 May 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1002/advs.202504704
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202504704
Apr 2025
aacrjournals.org aacrjournals.org

Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T Cell Pyrimidine Synthesis

1
1. scibot 17 Apr 2025
  
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  RRID: CVCL_7254
  
  DOI: 10.1158/0008-5472.CAN-24-1875
  
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  Curator: @areedewitt04
  
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aacrjournals.org/cancerres/article/85/4/692/751418/Adenosine-Uptake-through-the-Nucleoside
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 24 Mar 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/1535-7163.mct-24-0545
  
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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy

1
1. scibot 20 Mar 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1080/2162402X.2025.2478850
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11913393/
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Mechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages

1
1. scibot 18 Mar 2025
  
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  RRID:CVCL_7254
  
  DOI: 10.1177/15347354251325806
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898227/
Feb 2025
pubs.acs.org pubs.acs.org

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

1
1. scibot 20 Feb 2025
  
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  RRID: CVCL_7254
  
  DOI: 10.1021/acs.bioconjchem.4c00534
  
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pubs.acs.org/doi/full/10.1021/acs.bioconjchem.4c00534
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Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition

1
1. scibot 13 Feb 2025
  
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  RRID: CVCL_7254
  
  DOI: 10.1158/1541-7786.MCR-23-0513
  
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aacrjournals.org/mcr/article/22/6/538/745428/Serotonin-Receptor-HTR2B-Facilitates-Colorectal
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor–Node–Metastasis Stages

1
1. scibot 21 Dec 2024
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/2767-9764.CRC-24-0270
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11589669/
Nov 2024
52.53.155.43 52.53.155.43

crc-24-0270-html.html

1
1. scibot 07 Nov 2024
  
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  RRID:CVCL_7254
  
  DOI: 10.1158/2767-9764.crc-24-0270
  
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52.53.155.43/6812950de7f1da66ce36837432902250c74146ab/crc-24-0270-html.html
Oct 2024
aacrjournals.org aacrjournals.org

Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation

1
1. scibot 02 Oct 2024
  
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  RRID: CVCL_7254
  
  DOI: 10.1158/2326-6066.CIR-20-1043
  
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  Curator: @bandrow
  
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aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
Sep 2024
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Altered epitopes enhance macrophage-mediated anti-tumour immunity to low-immunogenic tumour mutations

1
1. scibot 27 Sep 2024
  
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  RRID:CVCL_7254
  
  DOI: 10.1111/imm.13854
  
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onlinelibrary.wiley.com/doi/10.1111/imm.13854
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Ethanol promotes alcohol-related colorectal cancer metastasis via the TGF-β/RUNX3/Snail axis by inducing TGF-β1 upregulation and RUNX3 cytoplasmic mislocalization

1
1. scibot 25 Sep 2024
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.ebiom.2019.11.011
  
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  Curator: @ethanbadger
  
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  RRID:CVCL_7255 RRID:CVCL_7254 RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S2352396419307522
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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

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  DOI: 10.1016/j.cell.2019.07.019
  
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Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer

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IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth

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  DOI: 10.1016/j.biopha.2024.117412
  
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Association of appendectomy with prognosis and tumor-associated macrophages in patients with colorectal cancer

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Aug 2024
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Tumor cell-expressed lipolysis-stimulated lipoprotein receptor negatively regulates T-cell function

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Molecular Oncology - 2023 - Pan-html.html

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Jul 2024
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The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC11234499/
Apr 2024
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Type I interferon regulation by USP18 is a key vulnerability in cancer

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The immune suppressor IGSF1 as a potential target for cancer immunotherapy

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XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies

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ncbi.nlm.nih.gov/pmc/articles/PMC10993987/
Feb 2024
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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor

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Nov 2023
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An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

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Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy

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Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

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onlinelibrary.wiley.com/doi/full/10.1002/ijc.34695
Aug 2023
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Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy

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Jul 2023
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Comparison of the effects of probiotic strains (Lactobacillus gasseri, Lactiplantibacillus plantarum, Lactobacillus acidophilus, and Limosilactobacillus fermentum) isolated from human and food products on the immune response of CT26 tumor–bearing mice

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link.springer.com/article/10.1007/s42770-023-01060-9
May 2023
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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

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  DOI: 10.1038/s41467-023-38605-3
  
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Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter

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Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic

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Apr 2023
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IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

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aacrjournals.org/cancerrescommun/article/3/4/576/725855/IOA-244-is-a-Non-ATP-competitive-Highly-Selective
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Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting

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Feb 2023
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CTLA-4 inhibition facilitates follicular T and B cell interaction and the production of tumor-specific antibodies

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onlinelibrary.wiley.com/doi/10.1002/ijc.34438
Jan 2023
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Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

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aacrjournals.org/cancerdiscovery/article/12/8/1942/707227/Enhancing-PD-L1-Degradation-by-ITCH-during-MAPK
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Immunotherapies targeting neoantigens are effective in PD-1 blockade-resistant tumors

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onlinelibrary.wiley.com/doi/10.1002/ijc.34382
Oct 2022
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Sirpiglenastat (DRP-104) Induces Anti-tumor Efficacy Through Direct, Broad Antagonism of Glutamine Metabolism and Stimulation of the Innate & Adaptive Immune Systems

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aacrjournals.org/mct/article/21/10/1561/709527/Sirpiglenastat-DRP-104-Induces-Antitumor-Efficacy
Aug 2022
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Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers

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Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways

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onlinelibrary.wiley.com/doi/10.1002/ptr.7588
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A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors

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onlinelibrary.wiley.com/doi/10.1002/ijc.34218
Feb 2022
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Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

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Jan 2022
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SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models

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onlinelibrary.wiley.com/doi/10.1002/cti2.1364
Oct 2021
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XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer

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nature.com/articles/s41392-021-00761-7
Sep 2021
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Inhibition of BCL9 Modulates the Cellular Landscape of Tumor-Associated Macrophages in the Tumor Immune Microenvironment of Colorectal Cancer

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  DOI: 10.3389/fphar.2021.713331
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8461101/
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Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors

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  DOI: 10.1002/ijc.33786
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.33786
May 2021
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Suppression of β-catenin signaling in colon carcinoma cells by a bacterial protein

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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1. scibot 06 May 2021
  
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  RRID:CVCL_7254
  
  DOI: 10.1016/j.immuni.2020.06.016
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_7254
  
  What is this?
  
  RRID:CVCL_7254
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RRID:CVCL_7254

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320302715
Mar 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Nanofitins targeting heat shock protein 110: an innovative immunotherapeutic modality in cancer.

1
1. scibot 08 Mar 2021
  
  in Public
  
  RRID:CVCL_7254
  
  DOI: 10.1002/ijc.33485
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_7254
  
  What is this?
  
  RRID:CVCL_7254
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RRID:CVCL_7254

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scibot

URL

onlinelibrary.wiley.com/doi/full/10.1002/ijc.33485
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Cetuximab enhances the anti-tumor function of macrophages in an IL-6 dependent manner

1
1. scibot 27 Feb 2021
  
  in Public
  
  CVCL_7254
  
  DOI: 10.1016/j.lfs.2020.118953
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_7254
  
  What is this?
  
  RRID:CVCL_7254
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RRID:CVCL_7254

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scibot

URL

sciencedirect.com/science/article/pii/S0024320520317136
Sep 2020
academic.oup.com academic.oup.com

Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T cell-dependent manner

1
1. scibot 08 Sep 2020
  
  in Public
  
  RRID:CVCL_7254
  
  DOI: 10.1093/intimm/dxaa049
  
  Resource: (KCLB Cat# 80009, RRID:CVCL_7254)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_7254
  
  What is this?
  
  RRID:CVCL_7254 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_7254

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scibot

URL

academic.oup.com/intimm/intimm/advance-article-abstract/doi/10.1093/intimm/dxaa049/5878926

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