2 Matching Annotations
  1. Jan 2021
  2. Feb 2017
    1. A breakthrough in our understanding came about when we ablated the renin cells in mice by targeting diphtheria toxin subunit A into the renin gene.31 Although these animals had renal abnormalities, the arteriolar hypertrophy was prevented (Figure 1), indicating that the hypertrophy occurred because the cells themselves directly or by the production of a growth factor(s) contributed to the vascular lesions.

      Fascinating discovery targeting diphtheria toxin subunit A.