- May 2022
-
www.scienceintheclassroom.org www.scienceintheclassroom.org
-
In this case, the asymmetry of the trace of fluorescence intensity as a function of time measured near the end of the channel (green trace inFig. 4B) indicates that the band is still broadening rapidly as it reaches the end of the channel:
Figure 4B shows the spread of a fluorescent plug introduced into a straight channel. As the plug moves along the channel, it spreads out due to a process called axial dispersion. As a result its length increases and its intensity decreases. Axial dispersion is often an undesired phenomenon observed in microfluidic devices.
-
- Apr 2022
-
www.scienceintheclassroom.org www.scienceintheclassroom.org
-
McDonald J. C., et al., Electrophoresis 21, 27 (2000).
This paper is the first to report the use of PDMS in the fabrication of microdevices and discusses its pros and cons. The paper introduced soft lithography based on PDMS as a novel fabrication method for microfluidic devices, which is commonly used in academic research and industry.
-
Liu R. H., et al., J. Microelectromech. Syst. 9, 190 (2000)
This paper shows an alternative form of fluid mixing in microfluidic channels. This method uses curved channels with serpentine geometry to mix fluids by generating chaotic flow similar to the one presented in this paper.
-
Dunn D. A., Feygin I., Drug Discovery Today 5, S84 (2000)
This article outlines a common use of microfluidics, that is the miniaturization of assays to run many of them in parallel at the same time ((high throughput assays). This paper addresses one of the main problems in assay miniaturization, which is efficient mixing of assay components.
-
- Mar 2022
-
www.scienceintheclassroom.org www.scienceintheclassroom.org
-
This design adds a negligible resistance to flow relative to that of a simple channel of the same dimensions
This method of mixing can be adapted to most microfluidic devices as it has a negligible effect on the overall flow characteristics.
-
The angular displacement, Δφm, is controlled by the geometry of the ridges
The mixing efficiency (which is a function of angular displacement) can be optimized by changing the shape and the dimensions of the ridges.
-
Furthermore, the experimentally observed dependence of the average rate of rotation,dΔφ/dy, on geometrical parameters (q, h, w, and θ) can be rationalized with a simple model
Earlier studies have discovered how these two parameters effect each other. The authors developed a model to predict the effect of each geometrical parameter on the mixing efficiency.
-
layer-by-layer geometries
Lithography techniques rely on fabricating one layer at a time to construct device features at the microscale.
-
Pe ́cletnumber
A dimensionless number that represents the ratio of the rate of transport by bulk motion of a fluid to the rate of transport by diffusion.
-
- Feb 2022
-
www.scienceintheclassroom.org www.scienceintheclassroom.org
-
Re
Re is an abbreviation for Reynolds number.
-
bas-relief structures
Ridge like structures used to disrupt laminar flow patterns
-
hydrodynamic dispersion
The spreading out of a solute in a stream of fluid.
-
Microfluidic
A device that uses small amounts of liquid on a microscopic scale
-