22 Matching Annotations
  1. Apr 2020
  2. Mar 2020
    1. endoscopic overtube

      An endoscopic overtube is a sleeve-like device designed for both upper and lower endoscopic procedures. During upper endoscopy it is designed to protect the hypopharynx from the trauma of repeated intubations, the airway from aspiration, and the esophagus during extraction of sharp foreign bodies.

    2. 45 ± 2 pg/ml (n = 3) and 54 ± 29 pg/ml (n = 3) on days 3 and 11, respectively.

      Using the capsule with three arms, they found concentrations of 45 ± 2 pg/ml on day 3 and 54 ± 29 pg/ml on day 11. These results illustrate that the capsule is steadily releasing the hormone over a 20-day period. One problem with this formulation is that the drug concentration fluctuates significantly over time which may reduce its effectiveness for pregnancy protection.

    3. Using long-acting formulation–1, we observed a maximal concentration of 55 ± 18 pg/ml (n = 3) on day 17 (Fig. 2B).

      Using the capsule with half of the drug loaded in poly(sebacic anhydride) and the other half in PDMS, the authors illustrated birth control drug delivery for an extended period. They observed a peak concentration of the drug on day 17. This shows that, unlike the daily tablet, their formulation slowly and steadily releases the drug and provides protection over a longer period.

    4. 126 ± 24 pg/ml (n = 3) on day 2

      Using the capsule with six loaded arms of PDMS, a maximum concentration was reached on day 2. Note how the maximum concentration is 126 ± 24 pg/ml, as opposed to the latter configuration with a maximum concentration of 55 ± 18 pg/ml.

  3. Feb 2020
    1. poly(anhydride)-based matrices

      A class of biodegradable polymers which are characterized by anhydride bonds. In vivo, they degrade into non- toxic monomers that are metabolized and eliminated from the body.

    2. Bonferroni

      A statistical analysis test used to counteract false positive results within multiple comparisons. It is used when several independent or dependent tests are being performed simultaneously.