7,819 Matching Annotations
  1. Sep 2025
  2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Prevalence of delirium, depression, anxiety, and post-traumatic stress disorder among COVID-19 patients: protocol for a living systematic review
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    pubmed.ncbi.nlm.nih.gov/33158456/
  3. bmjopen.bmj.com bmjopen.bmj.com
    Social determinants of homelessness from childhood to adolescence: protocol for a living systematic review and meta-analysis
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    bmjopen.bmj.com/content/15/6/e095164
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    Cannabis for pediatric epilepsy: protocol for a living systematic review
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    pubmed.ncbi.nlm.nih.gov/30021618/
  5. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Clinico-epidemiological characteristics of Kawasaki-like disease in paediatric patients with COVID-19: a protocol for rapid living systematic review
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    pubmed.ncbi.nlm.nih.gov/33361078/
  6. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Conservative and surgical modalities in the management of paediatric parapneumonic effusion and empyema: a protocol for a living systematic review and network meta-analysis
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    pubmed.ncbi.nlm.nih.gov/33762243/
  7. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Possible vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19: A living systematic review
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    pubmed.ncbi.nlm.nih.gov/33090535/
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    Transmission of SARS-CoV-2 through breast milk and breastfeeding: a living systematic review
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    pubmed.ncbi.nlm.nih.gov/32860259/
  9. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Clinical manifestations, prevalence, risk factors, outcomes, transmission, diagnosis and treatment of COVID-19 in pregnancy and postpartum: a living systematic review protocol
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    pubmed.ncbi.nlm.nih.gov/33268430/
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    What are the long-term symptoms and complications of COVID-19: a protocol for a living systematic review
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    pubmed.ncbi.nlm.nih.gov/34621523/
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    What is the evidence for transmission of COVID-19 by children in schools? A living systematic review
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    pubmed.ncbi.nlm.nih.gov/33437465/
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    Development and evaluation of prompts for a large language model to screen titles and abstracts in a living systematic review
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    pubmed.ncbi.nlm.nih.gov/40701625/
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    Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis
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    bmj.com/content/370/bmj.m3320
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    Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review
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    pubmed.ncbi.nlm.nih.gov/31754425/
  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cannabinoids for Medical Purposes in Children: A Living Systematic Review
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    onlinelibrary.wiley.com/doi/10.1111/apa.70140
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    Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer
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    pubmed.ncbi.nlm.nih.gov/29920657/
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    Effective uses of social media in public health and medicine: a systematic review of systematic reviews
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    pubmed.ncbi.nlm.nih.gov/30349633/
  18. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis
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    pubmed.ncbi.nlm.nih.gov/32960881/
  19. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Comparative effectiveness of treatments for patellofemoral pain: a living systematic review with network meta-analysis
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    COVID-19 and patients with immune-mediated inflammatory diseases undergoing pharmacological treatments: a rapid living systematic review
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    A Living Systematic Review of Nebulized Hypertonic Saline for Acute Bronchiolitis in Infants
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    Screening Coverage Needed to Reduce Mortality from Prostate Cancer: A Living Systematic Review
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  23. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    From living systematic reviews to meta-analytical research domains
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  24. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies
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    pubmed.ncbi.nlm.nih.gov/40832127/
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    Living network meta-analysis to compare nemolizumab against other available targeted systemic treatments for atopic dermatitis
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  26. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    HLA-B*58:01 genotyping prevalence and the association with allopurinol-induced severe cutaneous adverse reactions: a living systematic review and meta-analysis
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  28. www.sciencedirect.com www.sciencedirect.com
    A Living, Interactive Systematic Review and Network Meta-analysis of First-line Treatment of Metastatic Renal Cell Carcinoma
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    Safety profile of nivolumab-relatlimab in cancer patients: a living pharmacovigilance study of clinical trials and postmarketing data (version 1.0)
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    EE450 Treatments and Diagnostics for COVID-19: A Living Systematic Review of Economic Evaluations
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    sciencedirect.com/science/article/pii/S1098301522008993
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    Performance of point-of care molecular and antigen-based tests for SARS-CoV-2: a living systematic review and meta-analysis
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    sciencedirect.com/science/article/pii/S1198743X22005420
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    (5) COVID-19 Vaccination Strategies in Solid Organ Transplant Recipients: A Living Systematic Review and Network Meta-Analysis
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    sciencedirect.com/science/article/pii/S1053249823000633
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    Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis – Author’s reply
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    Evidence Map of Pancreatic Surgery - Living Systematic Review and Meta-Analysis
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    1417P Mixed treatment comparisons evaluating contemporary therapies in metastatic castration sensitive prostate cancer (mCSPC): A living systematic review
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    The safety of digestive tract cancer surgery during COVID-19: A living systematic review and meta-analysis
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    A living systematic review on anti-HIV, anti-TB and anti-malarial drug unavailability and their impact on infection management
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    Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review
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    Endovascular thrombectomy for large ischemic strokes: An updated living systematic review and meta-analysis of randomized clinical trials
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    Early goal-directed therapy for severe sepsis and septic shock: A living systematic review
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    Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis
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    Diagnostics and Treatments of COVID-19: A Living Systematic Review of Economic Evaluations
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    PIH19 Dosing and Safety of Medical Cannabis in Children: Preliminary Findings from a Living Systematic Review
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    Mesenchymal stem/stromal cell–based therapies for COVID-19: First iteration of a living systematic review and meta-analysis: MSCs and COVID-19
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    Mesenchymal Stromal Cells As a Therapeutic Intervention for COVID-19: Second Iteration of a Living Systematic Review and Meta-Analysis
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    International alliance and AGREE-ment of 71 clinical practice guidelines on the management of critical care patients with COVID-19: a living systematic review
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    Toxicity Profile of Janus Kinase Inhibitors (JAKi) in Patients with Myelofibrosis: A Report from a Living Systematic Review and Meta-Analysis
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    ICU decision making based on Living Systematic Review strategy during SARS-CoV-2 pandemic. Results of a prospective case serie
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    Clinical efficacy and safety of SARS-CoV-2-neutralizing monoclonal antibody in patients with COVID-19: A living systematic review and meta-analysis
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    CO4 The True Value of Living Systematic Reviews (LSRs): A Case Report Within Systemic Lupus Erythematosus (SLE)
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    sciencedirect.com/science/article/pii/S1098301524029449
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    Immediate versus delayed versus no antibiotics for respiratory infections
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    Interventions for myopia control in children: a living systematic review and network meta‐analysis
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    Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review
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    Methodological quality and reporting quality of COVID-19 living systematic review: a cross-sectional study
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    bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-023-01980-y
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    Interventions for myopia control in children: a living systematic review and network meta-analysis
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    Duration of antibiotic treatment for Gram-negative bacteremia – Systematic review and individual participant data (IPD) meta-analysis
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    Efficiency of Microorganisms and Effectiveness of Biodegradation Techniques on LDPE Plastics: A Systematic Review
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    Oral Health and Hygiene Status of Global Transgender Population: A Living Systematic Review and Meta-Analysis
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    Abstract TP25: Benefits and Risks of Antiplatelet Versus Thrombolysis for Mild Acute Ischemic Stroke: Update of a Living Systematic Review and Meta-analysis | Stroke
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  69. preprints.jmir.org preprints.jmir.org
    Prospective and multicenter study to assess the safety and effectiveness of a physiotherapy treatment through self-myofascial release with Foam Roller in patients with hemophilic ankle arthropathy. A randomized clinical trial.
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    A living systematic review of the use of Metaverse in L2 English education
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    Artificial Intelligence Solutions to Improve Emergency Department Wait Times: Living Systematic Review
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    Systemic treatment options for metastatic castration resistant prostate cancer: A living systematic review
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    Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain
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    Prognostic Value of Blood-Based Protein Biomarkers in Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis | Journal of Neurotrauma
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  80. www.bmj.com www.bmj.com
    Prophylaxis against covid-19: living systematic review and network meta-analysis
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    Abstract 159: Transradial versus transfemoral access for endovascular thrombectomy: A Living Systematic Review and Updated Meta‐Analysis | Stroke: Vascular and Interventional Neurology
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    POS0514 Long-term use of glucocorticoids in people with rheumatoid arthritis: a Cochrane living systematic review
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    Role of Magnesium in Cardiovascular Diseases : Cardiology in Review
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    open-research-europe.ec.europa.eu/articles/4-202/v2
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    Methodology in the Mirror: A Living, Systematic Review of Works in Quantitative Ethnography
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    Antiplatelet therapy versus intravenous thrombolysis for mild acute ischaemic stroke: a living systematic review and meta-analysis
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    svn.bmj.com/content/10/2/e003097
  87. journals.plos.org journals.plos.org
    Sexual transmission of Zika virus and other flaviviruses: A living systematic review
    1
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    journals.plos.org/plosmedicine/article
  88. pubs.rsna.org pubs.rsna.org
    Comparative Effectiveness of Coronary CT Angiography and Standard of Care for Evaluating Acute Chest Pain: A Living Systematic Review and Meta-Analysis | Radiology: Cardiothoracic Imaging
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    pubs.rsna.org/doi/full/10.1148/ryct.230022
  89. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Making the most of big qualitative datasets: a living systematic review of analysis methods
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    pubmed.ncbi.nlm.nih.gov/39385754/
  90. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Correction potential and outcome of various surgical procedures for hallux valgus surgery: a living systematic review and meta-analysis
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    pubmed.ncbi.nlm.nih.gov/39249135/
  91. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Systemic Immunomodulatory Treatments for Atopic Dermatitis: Living Systematic Review and Network Meta-Analysis Update
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    pubmed.ncbi.nlm.nih.gov/39018058/
  92. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus-A living systematic review and meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/39136500/
  93. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal
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    pubmed.ncbi.nlm.nih.gov/38102484/
  94. open-research-europe.ec.europa.eu open-research-europe.ec.europa.eu
    Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in hematologic malignancies: a living systematic review (protocol)
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    open-research-europe.ec.europa.eu/articles/2-38/v2
  95. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/38008405/
  96. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data
    1
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    pubmed.ncbi.nlm.nih.gov/39036710/
  97. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Quality and Accessibility of Home Assessment mHealth Apps for Community Living: Systematic Review
    1
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    pubmed.ncbi.nlm.nih.gov/38466987/
  98. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Comparing binary efficacy outcomes for systemic immunomodulatory treatments for atopic dermatitis in a living systematic review and network meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/37831594/
  99. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Primary surgery versus primary rehabilitation for treating anterior cruciate ligament injuries: a living systematic review and meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/36038357/
  100. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians
    1
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    pubmed.ncbi.nlm.nih.gov/36592455/
  101. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Effectiveness of Conservative Interventions After Acute Hamstrings Injuries in Athletes: A Living Systematic Review
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    pubmed.ncbi.nlm.nih.gov/36622557/
  102. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Results from a living systematic review of the prevalence of mood and anxiety disorders and factors associated with symptoms in systemic sclerosis
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    pubmed.ncbi.nlm.nih.gov/36997795/
  103. jamanetwork.com jamanetwork.com
    “Living” Systematic Review of Mental Health During Pandemic
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    jamanetwork.com/journals/jama/fullarticle/2802702
  104. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Framework for a living systematic review and meta-analysis for the surgical treatment of bladder cancer: introducing EVIglance to urology
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    pubmed.ncbi.nlm.nih.gov/38045560/
  105. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Efficacy and safety of abrocitinib for the treatment of adolescents and adults with moderate-to-severe atopic dermatitis: update of a living systematic review and meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/38297930/
  106. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    https://doi.org/10.1101/2020.05.21.20109074
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    pubmed.ncbi.nlm.nih.gov/32511471/
  107. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Epidemiology of Traumatic Brain Injury in Europe: A Living Systematic Review
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    pubmed.ncbi.nlm.nih.gov/26537996/
  108. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Treatment of UTIs in Infants <2 Months: A Living Systematic Review
    1
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    pubmed.ncbi.nlm.nih.gov/34446534/
  109. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Evidence Map of Pancreatic Surgery-A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)
    1
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    pubmed.ncbi.nlm.nih.gov/34187695/
  110. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Living systematic review to assess the analgesic undertreatment in cancer patients
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    pubmed.ncbi.nlm.nih.gov/35014151/
  111. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Trail running injury risk factors: a living systematic review
    1
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    pubmed.ncbi.nlm.nih.gov/35022162/
  112. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis
    1
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    pubmed.ncbi.nlm.nih.gov/35293977/
  113. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Quarterly Progress Report: May 2021
    1
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    pubmed.ncbi.nlm.nih.gov/34228409/
  114. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Major Update: Remdesivir for Adults With COVID-19 : A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points
    1
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    pubmed.ncbi.nlm.nih.gov/33560863/
  115. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Apolipoprotein E4 Polymorphism and Outcomes from Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis
    1
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    pubmed.ncbi.nlm.nih.gov/30848161/
  116. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms
    1
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    pubmed.ncbi.nlm.nih.gov/29799308/
  117. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis
    1
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    pubmed.ncbi.nlm.nih.gov/29020853/
  118. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Adherence to Guidelines in Adult Patients with Traumatic Brain Injury: A Living Systematic Review
    1
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    pubmed.ncbi.nlm.nih.gov/26431625/
  119. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A New Approach to Evidence Synthesis in Traumatic Brain Injury: A Living Systematic Review
    1
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    pubmed.ncbi.nlm.nih.gov/26414062/
  120. link.springer.com link.springer.com
    Clinical testing of the cardiovascular effects of e-cigarette substitution for smoking: a living systematic review
    1
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    link.springer.com/article/10.1007/s11739-022-03161-z
  121. www.sciencedirect.com www.sciencedirect.com
    The association between influenza vaccination, cardiovascular mortality and hospitalization: A living systematic review and prospective meta-analysis
    1
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    sciencedirect.com/science/article/pii/S0264410X24000537
  122. www.bmj.com www.bmj.com
    Update to living systematic review on drug treatments for covid-19
    1
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    bmj.com/content/378/bmj.o1717
  123. www.bmj.com www.bmj.com
    Update to living systematic review on prediction models for diagnosis and prognosis of covid-19
    1
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    bmj.com/content/378/bmj.o2009
  124. www.bmj.com www.bmj.com
    Update to living systematic review
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    bmj.com/content/369/bmj.m2204
  125. www.bmj.com www.bmj.com
    Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal
    1
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    bmj.com/content/369/bmj.m1328
  126. www.bmj.com www.bmj.com
    Update to living systematic review on effectiveness of heterologous and homologous covid-19 vaccine regimens
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    bmj.com/content/379/bmj.o2865
  127. www.bmj.com www.bmj.com
    Update to living systematic review on prophylaxis against covid-19
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    bmj.com/content/380/bmj.p688
  128. www.bmj.com www.bmj.com
    Update to living systematic review on covid-19 in pregnancy
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    bmj.com/content/377/bmj.o1205
  129. www.bmj.com www.bmj.com
    Update to living systematic review on SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission
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    bmj.com/content/384/bmj.p2929
  130. www.bmj.com www.bmj.com
    SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis
    1
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    bmj.com/content/376/bmj-2021-067696
  131. www.bmj.com www.bmj.com
    Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis
    1
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    bmj.com/content/390/bmj-2024-083039
  132. f1000research.com f1000research.com
    Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barr&eacute; syndrome: From systematic review to living systematic review
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    f1000research.com/articles/7-196
  133. www.sciencedirect.com www.sciencedirect.com
    Prevalence of spasticity following stroke and its impact on quality of life with emphasis on disability in activities of daily living. Systematic review
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    sciencedirect.com/science/article/abs/pii/S0028384314603005
  134. www.bmj.com www.bmj.com
    Update to living systematic review on covid-19 in pregnancy
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    bmj.com/content/372/bmj.n615
  135. Aug 2025
  136. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A living meta-ecological study of the consequences of the COVID-19 pandemic on mental health
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7936586/
  137. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Psychological treatment of depression: A systematic overview of a 'Meta-Analytic Research Domain'
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    pubmed.ncbi.nlm.nih.gov/37178828/
  138. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use
    2
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    pubmed.ncbi.nlm.nih.gov/39665378/
  139. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interventions for increasing fruit and vegetable consumption in children aged five years and under
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    pubmed.ncbi.nlm.nih.gov/39312396/
  140. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Cannabis-based products for pediatric epilepsy: A systematic review
    1
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    pubmed.ncbi.nlm.nih.gov/30515765/
  141. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interventions for increasing fruit and vegetable consumption in children aged five years and under
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    pubmed.ncbi.nlm.nih.gov/28945919/
  142. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Five decades of research on psychological treatments of depression: A historical and meta-analytic overview
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    pubmed.ncbi.nlm.nih.gov/37971844/
  143. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interventions to prevent or cease electronic cigarette use in children and adolescents
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    pubmed.ncbi.nlm.nih.gov/37965949/
  144. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Conservative and Surgical Modalities in the Management of Pediatric Parapneumonic Effusion and Empyema: A Living Systematic Review and Network Meta-Analysis
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    pubmed.ncbi.nlm.nih.gov/37463660/
  145. www.mdpi.com www.mdpi.com
    Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments
    2
    1. lmichan 20 Aug 2025
      Besides, potential biotechnological uses of haloarchaeal pigments are poorly explored. This work summarises what it has been described so far about carotenoids from haloarchaea and their production at mid- and large-scale, paying special attention to the most recent findings on the potential uses of haloarchaeal pigments in biomedicine.

      Además, los posibles usos biotecnológicos de los pigmentos haloarqueales están poco explorados. Este trabajo resume lo descrito hasta la fecha sobre los carotenoides de las haloarqueas y su producción a mediana y gran escala, con especial atención a los hallazgos más recientes sobre los posibles usos de los pigmentos haloarqueales en biomedicina.

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    mdpi.com/1660-3397/17/9/524
  146. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Archaea and Their Potential Role in Human Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC145348/
  147. www.mdpi.com www.mdpi.com
    Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies
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    mdpi.com/1660-3397/22/4/167
  148. europepmc.org europepmc.org
    In vitro dual (anticancer and antiviral) activity of the carotenoids produced by haloalkaliphilic archaeon Natrialba sp. M6.
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    europepmc.org/article/MED/32249805
  149. europepmc.org europepmc.org
    Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.
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    europepmc.org/article/MED/31906001
  150. europepmc.org europepmc.org
    Biotechnological potentials of halophilic microorganisms and their impact on mankind.
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    europepmc.org/article/MED/35669848
  151. www.mdpi.com www.mdpi.com
    Biotechnological Potential of Extremophiles: Environmental Solutions, Challenges, and Advancements
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    mdpi.com/2079-7737/14/7/847
  152. www.mdpi.com www.mdpi.com
    Halocins and C50 Carotenoids from Haloarchaea: Potential Natural Tools against Cancer
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    mdpi.com/1660-3397/22/10/448
  153. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Carotenoids in Skin Photoaging: Unveiling Protective Effects, Molecular Insights, and Safety and Bioavailability Frontiers
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    pubmed.ncbi.nlm.nih.gov/40427459/
  154. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Haloalkaliphilic Archaea as Sources of Carotenoids: Ecological Distribution, Biosynthesis and Therapeutic Applications
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    pubmed.ncbi.nlm.nih.gov/40702599/
  155. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Extremophilic models for astrobiology: haloarchaeal survival strategies and pigments for remote sensing
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    pubmed.ncbi.nlm.nih.gov/31463573/
  156. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Deciphering Pathways for Carotenogenesis in Haloarchaea
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    pubmed.ncbi.nlm.nih.gov/32155882/
  157. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Haloferax mediterranei Cells as C50 Carotenoid Factories
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    pubmed.ncbi.nlm.nih.gov/33578828/
  158. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Haloarchaea: A Promising Biosource for Carotenoid Production
    1
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    pubmed.ncbi.nlm.nih.gov/33783738/
  159. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Haloarchaea have a high genomic diversity for the biosynthesis of carotenoids of biotechnological interest
    1
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    pubmed.ncbi.nlm.nih.gov/34942349/
  160. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines
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    pubmed.ncbi.nlm.nih.gov/37514016/
  161. link.springer.com link.springer.com
    Microbial Bacterioruberin: A Comprehensive Review
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    link.springer.com/article/10.1007/s12088-024-01312-8
  162. www.nature.com www.nature.com
    Structural proteomics of an archaeon
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    nature.com/articles/nsb1000_903
  163. www.microbiologyresearch.org www.microbiologyresearch.org
    Haloparvum sedimenti gen. nov., sp. nov., a member of the family Haloferacaceae
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    microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.001033
  164. www.microbiologyresearch.org www.microbiologyresearch.org
    Halostagnicola alkaliphila sp. nov., an alkaliphilic haloarchaeon from commercial rock salt
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    microbiologyresearch.org/content/journal/ijsem/10.1099/ijs.0.023119-0
  165. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The response of selected members of the archaea to the gram stain
    1
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    pubmed.ncbi.nlm.nih.gov/8885405/
  166. link.springer.com link.springer.com
    Compilation of Analytical Techniques for Discrimination of Halophilic Archaea and Bacteria
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    link.springer.com/article/10.1134/S1062359022130167
  167. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10303815/
  168. academic.oup.com academic.oup.com
    Carotenoids produced by halophilic bacterial strains on mural paintings and laboratory conditions
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    academic.oup.com/femsle/article-abstract/366/21/fnz243/5645233
  169. link.springer.com link.springer.com
    Pigments of Halophilic Microorganisms
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    link.springer.com/chapter/10.1007/0-306-48053-0_6
  170. link.springer.com link.springer.com
    Antioxidant potential of pigments produced by halophilic archaea isolated from salt pans of India
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    link.springer.com/article/10.1007/s42398-024-00313-z
  171. www.frontiersin.org www.frontiersin.org
    Probing archaeal cell biology: exploring the use of dyes in the imaging of Sulfolobus cells
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    frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1233032/full
  172. www.microbiologyresearch.org www.microbiologyresearch.org
    Halobium palmae gen. nov., sp. nov., an extremely halophilic archaeon isolated from a solar saltern
    2
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    microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.001267
  173. www.nature.com www.nature.com
    Novel haloarchaeon Natrinema thermophila having the highest growth temperature among haloarchaea with a large genome size
    1
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    nature.com/articles/s41598-018-25887-7
  174. www.microbiologyresearch.org www.microbiologyresearch.org
    International Journal of Systematic and Evolutionary Microbiology
    1
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    microbiologyresearch.org/content/journal/ijsem
  175. journals.asm.org journals.asm.org
    The Mode of Cell Wall Growth in Selected Archaea Is Similar to the General Mode of Cell Wall Growth in Bacteria as Revealed by Fluorescent Dye Analysis | Applied and Environmental Microbiology
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