7,054 Matching Annotations
  1. Mar 2020
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    A recent paper has shown that novel coronavirus 2019-nCoV uses the SARS-coronavirus receptor ACE2 and the transmembrane protease serine-2 (TMPRSS2) for entering the target cells (https://www.biorxiv.org/content/10.1101/2020.01.31.929042v1?fbclid=IwAR2pEpKv1VN3o2zjUD0RjguQFtspH0nb5qhvYUt3z1evyNwVYFI-A1ylumU). Today we would like to share with you what kind of information is contained on ACE2 in another database, BRENDA™, which we distribute. According to the record in BRENDA™, ACE2 is associated with quite a number of diseases in human, among them heart failure, hypertension, acute lung injury, infections (associated with SARS & influenza). The record mentions about 100 inhibitors; for some even the concentration used in experiment and the amount of inhibition is provided directly. ACE2 exists as membrane-bound and as a soluble form. The latter is generated by cleavage of the membrane-bound form (Brenda ref 707074 =PMID 19411314). In case of the SARS-associated coronavirus (SARS-CoV) the membrane-bound form of ACE2 serves as virus receptor in vitro, and shedding is not required for infection to occur. The transmembrane protease serine-2 (TMPRSS2) has found to activate the spike protein of the SARS-CoV and to positively affect entry of the virus. Many more challenging and thrilling findings will have to be made to completely elucidate all facets of the 2019-nCoV novel coronavirus and its action. We hope very much that powerful information resources, like the databases of our portfolio, will contribute to this fight. #coronavirus #Covid19 #Covid_19 #2019nCoV #BRENDA #geneXplain
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  3. Feb 2020
  4. Jan 2020
  5. Oct 2019
    1. #Collections #Institutions #CatalogedItems #Taxa #TaxonRelations #Localities #GeoreferencedLocalities #CollectingEvents #Media #Agents #Publications #PublicationsWithDOI #Projects #GenBankLinks #SpecimenRelationships #Annotations #ReviewedAnnotations 178 38 3,720,566 3,422,043 1,106,234 580,184 430,122 1,076,518 788,957 91,225 8,002 1,491 2,875 31,635 112,990 15,179 992

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      178 38 3,720,566 3,422,043 1,106,234 580,184 430,122 1,076,518 788,957 91,225 8,002 1,491 2,875 31,635 112,990 15,179 992

    2. 3,422,043

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    1. Search species 6,586,578 results

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    1. The Catalogue of Life (CoL) is the nearest thing to a comprehensive catalogue of all known species of organisms on Earth. Continuous progress is made towards completion, and this edition contains 1,837,565 living and 63,418 extinct species.

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    1. urrently, EOL hosts 12,983,401 trait and attribute records, including 1,642,463 ecological interaction records. There is trait data available for 1,999,030 species and higher taxa.

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  6. Jun 2019