12 Matching Annotations
  1. Nov 2020
    1. The use of antioxidants to prevent some diseases is controversial.[53] In a high-risk group like smokers, high doses of beta carotene increased the rate of lung cancer since high doses of beta-carotene in conjunction of high oxygen tension due to smoking results in a pro-oxidant effect and an antioxidant effect when oxygen tension isn't high.[54][55] In less high-risk groups, the use of vitamin E appears to reduce the risk of heart disease.[56] However, while consumption of food rich in vitamin E may reduce the risk of coronary heart disease in middle-aged to older men and women, using vitamin E supplements also appear to result in an increase in total mortality, heart failure, and hemorrhagic stroke
    1. High doses of some antioxidants may have harmful long-term effects. The beta-Carotene and Retinol Efficacy Trial (CARET) study of lung cancer patients found that smokers given supplements containing beta-carotene and vitamin A had increased rates of lung cancer.[22] Subsequent studies confirmed these adverse effects.[23] These harmful effects may also be seen in non-smokers, as one meta-analysis including data from approximately 230,000 patients showed that β-carotene, vitamin A or vitamin E supplementation is associated with increased mortality, but saw no significant effect from vitamin C
  2. May 2019
    1. Add revenue.  Reduce costs.  Those are your only goals.

      This is sensible advice, but not actionable for many engineers without business knowledge. Being hired to "add revenue and/or reduce costs" means understanding the business; in many cases this makes people think of you as more than a "programmer". It may be intimidating, but I think most people on this path will tell you it's not such a big deal. Erik Dietrich calls these people "efficiencers", and if it sounds like something you'd like to do you should read as much of his blog as you can, starting with this: https://daedtech.com/the-efficiencers-guide-getting-started/. Seems like McKenzie has something slightly different in mind, something between a "programmer" and "efficiencer".