Walter Duranty, the then Moscow Bureau Chief of the New York Times, ignored and even denied the famine despite overwhelming eyewitness testimony. In August 1933, Duranty reported, “Any report of a famine in Russia is today an exaggeration or malignant propaganda,” instead saying that there was a “food shortage” in the famine regions that have “caused heavy loss of life.”

The Tank Man

Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

Zákon č. 89/2012 Sb.