The models are developed in Python [46], using the Keras [47] and Tensorflow [48] libraries. Detailson the code and dependencies to run the experiments are listed in a Readme file available togetherwith the code in the Supplemental Material.

These results nonetheless show that it could be feasible to develop recurrent neural network modelsable to infer input-output behaviours of real biological systems, enabling researchers to advance theirunderstanding of these systems even in the absence of detailed level of connectivity.

We show that GRU models with a hidden layersize of 4 units are able to accurately reproduce with high accuracy the system’sresponse to very different stimuli.

In our research, i.e., the wormnet project, we try to build machine learning models motivated by the C. elegans nervous system. By doing so, we have to pay a cost, as we constrain ourselves to such models in contrast to standard artificial neural networks, whose modeling space is purely constraint by memory and compute limitations. However, there are potentially some advantages and benefits we gain. Our objective is to better understand what’s necessary for effective neural information processing to emerge.