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  1. May 2018
    1. One group received citalopram (up to 60 mg/day) plus vitamin C (up to 1,000 mg/day). The other group received citalopram plus placebo.

      Considering the results of other trials with different depression severities and vitamin C dosage and forms (sustained release) (covered in this article), it is astonishing that the researchers used such a single, modest, non-sustained release dose.

      The plasma peak of vitamin C is obtained a few hours after the administration. For the rest of the day, the subject is back to baseline.

      This is common knowledge.