Figure 4: NMDA / AMPA receptor ratio at CL, Pf and cortical synapses on MSNs Postsynaptic excitatory currents were recorded from MSN held at +40 mV to reveal both AMPA receptor and NMDA receptor-mediated currents or just AMPA receptor-mediated currents in the presence of d-AP5. Each excitatory input has a distinct ratio of currents mediated by either receptor type. CL synapses on MSNs exhibit predominant AMPA receptor-mediated currents. Pf synapses on MSNs exhibit predominant NMDA receptor-mediated currents. Cortical inputs similarly exhibit predominant NMDA receptor-mediated expression, but to a lesser degree than Pf. The histogram shows the mean (± SEM) NMDA/AMPA receptor ratio for each synapse. Sourced from some citation

Figure 5: Long term plasticity at Pf, but not CL, synapses

Figure 3: Dynamic properties of CL, Pf and cortical synapses on MSNs

Figure 2: The majority of MSNs receive both thalamic and cortical input

1: Localized transfection of thalamic neurons in the central lateral or parafascicular thalamic nucleus