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I would say the epigenetic inheritance that has to occur there and how it occurs must be contributing a very large fraction indeed to the differentiation process
for - answer - Denis Noble - to Michael Levin - question - What percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards ? - a very large fraction is epigenetic inheritance indeed.
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what percentage of the information that is used by an organism let's say embryogenesis onwards is genetic versus all other sources put together what what what would you guess as a as a breakdown
for - question - Michael Levin to - Denis Noble - percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards
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the only way you can visualize the vaces because they're too tiny to be visualized by standard microscopy labeling with florescent dyes is about the only way we can um easily identify what molecules have been passed down from the vesicles to The Germ cells but that's very restrictive you see because there will be millions of different molecules in a single visle to be faced with only being able to label three or four of those otherwise we can't make out the the differences is it's very tedious
for - evolution - work to identify non-DNA information passed down to germ line - millions of permutations - fluorescence technique applied to only a few at a time - tedious work - Denis Noble
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- evolution - work to identify non-DNA information passed down to germ line - millions of permutations - fluorescence technique applied to only a few at a time - tedious work - Denis Noble
- question - Michael Levin to - Denis Noble - percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards
- nswer - Denis Noble - to Michael Levin - question - What percentage of genetic vs non-genetic information passed down to germ line from embryogenesis onwards ? - a very large fraction is epigenetic inheritance indeed.
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: t(27) = 2.66, p<0.05)
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t(27) = 5.31, p<0.01)
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t(44) = 3.10, p<0.05;
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vs. t(72) = 3.07, p<0.05)
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t(27) = 3.12, p<0.05)
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t(55) = 2.02, p<0.05)
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Irino & Tada 2009)
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Acknowledgements and funding
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Introduction
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t(72) = 1.73, p<0.05;
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: t(27) = 1.99, p<0.05;
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: t(27) = 1.98, p<0.05)
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Figure 5: Long term plasticity at Pf, but not CL, synapses
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Figure 3: Dynamic properties of CL, Pf and cortical synapses on MSNs
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Figure 2: The majority of MSNs receive both thalamic and cortical input
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1: Localized transfection of thalamic neurons in the central lateral or parafascicular thalamic nucleus
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bstract
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32%
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p=0.02)
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Irino, T; Tada, R (2009): Chemical and mineral compositions of sediments from ODP Site 127‐797. Geological Institute, University of Tokyo. http://dx.doi.org/10.1594/PANGAEA.726855
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