98 Matching Annotations
  1. Dec 2024
    1. for - polycrisis - crime - drug cartel - source: Endvr - The Netherlands - A Failed Narco State? Mocro Mafia - The Netherlands - The New Cocaine Mafias - 2024, Dec

      // - Summary - This documentary makes one thing clear, the solutions for the drug problem are inadequate because they are failing to address the root causes - The most insightful part of the entire documentary is near the end when the political leaders in Antwerp are discussing the problem - The leader of the conservative right hints at the right direction to look when he said that - there is a huge cognitive dissonance between - the drug users and - the drug suppliers - The meaning crisis is at the root of the drug crisis and until that is addressed in a systemic and meaningful way, it won't go away

    1. we kept looking at the a couple of assumptions and it was assuming almost a linear journey of we're going to take the power and the money from the elites and we're going to put it in the hands of the community and the peoples and what we know throughout history is many different social movements over the past hundreds of years have endeavored to make that shift. But unless we actually get down into the deeper thought forms that underlie power and domination themselves, we're not actually in a cold, liberatory kind of framework

      for - quote / key insight - must interrogate the deeper thought patterns else - we risk repeating simplistic linear transition social movements that have failed over the past centuries - Post Capitalist Philanthropy Webinar 1 - Alnoor Ladha - Lynn Murphy - 2023

  2. Nov 2024
    1. it's not generally known that the world wide web was my idea in the 1960s for 25 years I thought I would create worldwide hypertext but then another guy named berners-lee created his own version of worldwide hypertext which left out visible connection that other system caught on the great disappointment of my life what I called hypertext when I published the idea in 1965 was a deeper concept

      for - internet - history - Ted Nelson - early pioneer of World Wide Web and hypertext - advocated for visible connections - but failed to materialize

  3. May 2024
  4. Sep 2022
  5. Aug 2022
  6. Jul 2022
  7. May 2022
    1. "I didn't fully understand it at the time, but throughout my time as a freshman at Boston College I've realized that I have the power to alter myself for the better and broaden my perspective on life. For most of my high school experience, I was holding to antiquated thoughts that had an impact on the majority of my daily interactions. Throughout my life, growing up as a single child has affected the way am in social interactions. This was evident in high school class discussions, as I did not yet have the confidence to be talkative and participate even up until the spring term of my senior year."

  8. Apr 2022
  9. Aug 2021
  10. Jun 2021
  11. Apr 2021
    1. Piano Cat is a challenging rhythm-based platformer game where you [...] jump to the beat [...].No, no, no, just no. This game has nothing to do with rhythm or doing something in sync to the music. If you try to do that, you will fail, a lot. In order to beat the stages you have to mute or ignore the music, ignore the obstacles and only look out for the buttons you have to press. When they light up green, you press the button. This means that you have to press them always too early to the action, ahead of time. If you try to time it to the music, it will be too late and not count. If you are good in these kind of games, this will totally throw you off here.The graphic are nice, the music is ok, but it does a terrible job in having rhythm based gameplay.
  12. Feb 2021
  13. Oct 2020
  14. May 2020
    1. Given the massive amount of stars it had acquired on Github and the fairly quick and easy setup, it seemed very promising. When it comes down to its isomorphic functionality, it’s hard to match. But when it we started using the static export features, we were dropped on our faces with a very ungraceful transition from isomorphic to static that came with a cold side of faulty hot-reloading, strange routing strategies and highly bloated bundles:
  15. Jun 2019
    1. “Because the bully had no prior record of bullying, and even though there were so many different days and incidents of physical assault, it was treated as a one-time offense, and for a one-time offense you just get a short talk and a call home,”

      In order for suspension and expulsion, there must be multiple offense. In this case, there are witnesses and a confession, but that is not enough. Even though there were many different days and incidents of physical assault this is considered a one-time offense? A short talk and a phone call home is the consequences of a death threat and physical assault? Where is the importance of bullying would not be tolerated? Where is the importance of ensuring the victim's safety? This is why this whole system fail to tackle on the issue of bullying. The limit of what the school can do is unjust. How is that resolved? The victim and their family would still feel unsafe, fear, and paranoia.

  16. Nov 2016
    1. Have you considered including ORCIDs for every author? Although not compulsory, ORCIDs are a good way of making sure authors get credit for your work by distinguishing them from every other researcher in the world.

    2. Van der Werf YD, Witter MP, Groenewegen HJ (2002) The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev 39:107-140.

      This reference is cited

    3. This analysis revealed that the response to CL axon stimulation was consistently larger in amplitude than the response to Pf for both direct and indirect pathway MSNs (direct pathway: t(27) = 1.98, p<0.05).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    4. Secondly, the cortical response recovers more quickly than the thalamic response after both 10 Hz and 20 Hz stimulation (ratio of response to first pulse: 10 Hz; cortical 0.87 ± 0.05, vs. thalamic 0.57 ± 0.05, 20 Hz; cortical, 0.90 ± 0.12 vs. t(72) = 3.07, p<0.05).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    5. We found that the paired-pulse ratio (PPR) for afferents from CL are facilitating (t(55) = 2.02, p<0.05), whereas those from Pf are depressing (t(27) = 3.12, p<0.05).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    6. We found that CL synapses are dominated by AMPA receptor-mediated currents, whereas Pf synapses are dominated by NMDA receptor-mediated currents (t(27) = 5.31, p<0.01).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    7. Furthermore, the analysis revealed that the response to CL axon stimulation was larger in amplitude on direct pathway neurons (direct pathway: t(27) = 1.99, p<0.05; Table 1).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    8. Cortical synapses exhibit an NMDA/AMPA ratio in between those of CL and Pf synapses and dominated by NMDA receptor-mediated currents (mean NMDA/AMPA ratio for cortical: t(27) = 2.66, p<0.05).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    9. However, the same protocol applied to CL synapses did not lead to any change in the amplitude of evoked EPSPs (t(27) = 0.41, p<0.05; Figure 5A).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    10. The average amplitude of response following CL axon stimulation was 66.3 ± 13.5 pA (stim strength; 450 mW; n = 16), whereas those following Pf axon stimulation were significantly smaller at 30.7 ± 4.1 pA (stim strength: 980 mW; t = 0.81, p<0.05).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    11. The Pf response is significantly depressing following both the 10 and 20 Hz trains and the rate of recovery was the least of all three responses (t(44) = 3.10, p<0.05; Figure 3B).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    12. Whereas all responses depress eventually, only the responses of CL inputs are facilitating for the first few spikes during both 10 and 20 Hz stimulation CL (t(72) = 1.73, p<0.05;

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    13. We found that the EPSC properties for CL and Pf synapses using this stimulation strength are remarkably similar, with some small differences in that CL EPSCs were larger in amplitude (t = 2.31, p<0.05) and Pf EPSCs slightly longer in duration (t= 1.01, p=0.02).

      It's often good practice to accompany every p value with a confidence interval, or another measure of precision.

    14. Figure 4: NMDA / AMPA receptor ratio at CL, Pf and cortical synapses on MSNs Postsynaptic excitatory currents were recorded from MSN held at +40 mV to reveal both AMPA receptor and NMDA receptor-mediated currents or just AMPA receptor-mediated currents in the presence of d-AP5. Each excitatory input has a distinct ratio of currents mediated by either receptor type. CL synapses on MSNs exhibit predominant AMPA receptor-mediated currents. Pf synapses on MSNs exhibit predominant NMDA receptor-mediated currents. Cortical inputs similarly exhibit predominant NMDA receptor-mediated expression, but to a lesser degree than Pf. The histogram shows the mean (± SEM) NMDA/AMPA receptor ratio for each synapse. Sourced from some citation

      You've mentioned this figure in the article body