This may be the biggest problem. What is/are the factors that increase or decrease the need to sleep? How can we push against natural fatigue and its causes? How can we give people more wakefulness / conscious life per day? (without suffering significant debuffs)

This blog is very good, high signal and low noise. The dense version of this idea that has stuck with me is that the thing we're aiming for (productivity, make-world-better-stuff, doing good) is a multiplicative-product of both hustle (physical work, pressing buttons, saying words that other people hear) and the thinking part. That is, long term goal completion is hustle (doing stuff) * thought (knowing what to do)

I may technically disagree with the "most important thing" part, but it needs some sort of strong emphasis. Hustle modifies ideas in a times-ish (multiplying) way, so if you've got zero hustle, you don't really have anything

One way to do world-bettering is to just have enough hustle to outsource the hustle (get other people to act on your ideas), or alternately if you have tons of hustle, then you can take good ideas which aren't going anywhere.

Knowing the difference between bad and good ideas is one of the core problems with the super-connected society/net we're in. The solution to the problem is too large for this margin.