Armand Hammer, the son of Russian emigrants to the U.S., signed an agreement with the Soviet government to develop asbestos mines in the Urals

Spartacus (Greek: Σπάρτακος, translit. Spártakos; Latin: Spartacus; c. 103–71 BC) was a Thracian gladiator (Thraex) who, along with Crixus, Gannicus, Castus, and Oenomaus, was one of the escaped slave leaders in the Third Servile War, a major slave uprising against the Roman Republic.

Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

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