12 Matching Annotations
  1. Feb 2025
    1. the book I tell the story of Five addicts um one is a heroin addict one's a meth addict one was addicted to pharmaceutical uh opiates um the fourth one was a British man who was an alcoholic very serious alcoholic and the fifth one was an eating disordered person

      > for - book - The Biology of Desire - Why Addiction is not a Disease - 2015 Marc Lewis - https://dl.icdst.org/pdfs/files4/2a48405faa052ec2b4e0c56a79e001ca.pdf

    2. so that's the model

      > for - addiction model - Marc Lewis - addiction diagram

      > summary - Marc gives a good summary of everything - prefrontal cortex in control of judgment - striatum in charge of - attraction - desire - craving - midbrain - dopamine system - dopamine goes to the striatum and sets up localized feedback cycle so crave more - then the striatum becomes hyperactivated in the presence of cues - then you get that mechanism of now appeal - that narrowing of attraction to the immediate reward and - the loss of everything else - the other stuff falls off the radar - then the connection between - the prefrontal cortex and - the striatum starts to become compromised - resulting in ego fatigue - The prefrontal cortex simply becomes less effective at control

  2. Sep 2024