Age at Enspryng Initiation 47 (32, 55) 47 (30, 52)
Makes sense to me. Looks to be similar across cohorts
Age at Enspryng Initiation 47 (32, 55) 47 (30, 52)
Makes sense to me. Looks to be similar across cohorts
case-driven trial was planned 205to accrue 130case
What was the rationale for accrual of 130 cases has not been explained here. Would be nice to have that explanation. When the study parameters (95% confidence interval, 60% vaccine efficacy, 1% baseline attack rate) were applied to the WHO calculator obtained from here, the sample size turned out to be 86000, and when 80% confidence interval, 60% vaccine efficacy, and 1% baseline rate among unvaccinated) was used to assess sample size, it turned out to be 21000; in any case, the study then would be underpowered unless the rationale of 130 case accrual is made.<br> Why was not the WHO sample size estimator used?
Lakens, D. (2021). Sample Size Justification. PsyArXiv. https://doi.org/10.31234/osf.io/9d3yf
This is a page note. I can write overall comments about the pre-print here.
Tags can also be added below.
Power Analyses
Power Analyses with SPSS, R, Stata, SAS
Althouse, A. D. (2020). Post Hoc Power: Not Empowering, Just Misleading. Journal of Surgical Research, 0(0). https://doi.org/10.1016/j.jss.2019.10.049
Maarten van Smeden on Twitter: “This is a kind reminder that most issues with data (e.g. measurement error, incomplete data, confounding, selection) do not disappear just because you have N = ginormous” / Twitter. (n.d.). Twitter. Retrieved July 19, 2020, from https://twitter.com/MaartenvSmeden/status/1283313496382373890