Given how cheap and easy this intervention is, I'd say this is adequate evidence that all ME/CFS patients should be taking these supplements. Moreover. given that the p-value is so low, it is almost certain to be replicated.

That's a substantial fraction of the 11 point lower blood volume in ME/CFS found in one study. Moreover, this was achieved with only 13 days bed rest. I can only imagine the long-term effects of a sedentary lifestyle. It's likely that this is the primary cause of most ME/CFS. Nonetheless, exercise is unlikely to be the optimal treatment.

I notice the standard deviation is low for their sample size. Normally smaller sample sizes increase SD. However, comparing to a study with 30 subject per group, we can see the expected SD for blood volume (ml/kg) in this sample size of 20 should be greater than ±22.

The reason for this small SD is probably that subjects with ME/CFS are scrunched up against the lower end of the curve. The body simply will not allow blood volumes below a certain level. Judging by this study, I'd say around 50 ml/kg is the lowest possible number.

This is plausibly the reason why antioxidants enhance sleep. Though it is likely that there are other mechanisms as well, such as reduced neuroinflammation. Come to think of it, given that ME/CFS appears to be caused by high sympathetic tone during sleep, antioxidants are the perfect treatment. Antioxidants are proven in placebo-controlled trials to help with sleep in healthy subjects and insomniacs alike. I doubt that antioxidants can cure ME/CFS, but I'm confident they will help.

18:03 Loneliness leads to microarousals. Could this be a potential root cause of ME/CFS.

I'd like to see a trial of hemp protein for chronic fatigue syndrome.

I find the increased nighttime blood pressure suprising. Increased heart rate, on the other hand, is exactly what I might expect. Given that it is diastolic pressure that is elevated, I take it that the increased heart rate is the cause. If not, it could be that a stressor, like a hypopnea, is the underlying cause.

This further supports the link to ME/CFS. The ratio in the referenced study is about 2.5 to 1: female to male.

This makes Upper Airway Resistance Syndrome a prime suspect for ME/CFS. I presents many of the same symptoms, and may be the instigating factor. That does not mean, however, that UARS is the only cause, nor that treating UARS is necessarily sufficient to treat ME/CFS; a feedback loop may mean that other factors must be attended to.

Since the pain is caused be SWS interference, it might be difficult to disentangle cause and effect.