6 Matching Annotations
  1. Nov 2023
    1. we're in a position as a modern techno-industrial culture this is my view that it's false to say what the oil 00:29:32 companies are saying that we can keep producing oil and gas we'll get the society to pay for carbon capture and storage and and other stuff but it's going to be a technological salvation 00:29:44 and then we can keep on with our life that's one version the the other version is the environmentalist version which the federal government has bought into and that is we'll go green and then we 00:29:57 can keep everything
      • for: false dichotomy of sustaining modernity

      • paraphrase

        • The pace of modernity can neither be sustained in a high carbon nor a low carbon green economy
        • No matter what the political party, they all subscribe to a view of sustaining the same or greater pace of modernity
      • comment

        • libertarians want no constraints
        • but nature herself imposes limits
        • populations collapse if resources are overused
        • human populations who adopt a Libertarian approach eventually encounter a limit anyways
  2. Aug 2022
    1. She introduces a phenomenon she calls the "double bind for men" (232). Her explanation makes use of the more documented female double bind which is created by sexual object/prey stereotypes of women, and reduces women to choosing between being considered either a "virgin" or a "whore." In Serano's male double bind, the options are between "nice guy" and "asshole."
  3. Sep 2020
    1. I don’t want to force my opinion on you

      This is false. Betteredge himself confesses during this conversation that his thoughts were "muddled" until "Mr. Franklin took them in hand, and pointed out what they ought to see". Furthermore, wasn't it Franklin who pushed Betteredge to write his recollection in the first place? Franklin's influence on the Betteredge is apparent, putting into question the reliability of his narrative as well as Franklin's motives.

      It again brings up the dichotomy of opinion versus fact, subjective versus objective. This reminds me of "In a Grove" by Ryunosuke Akutagawa, which was adapted into the film "Rashomon" by Akira Kurosawa. Very similar themes and narrative structure.

    2. to put the Person before the Thing, which is but common politeness

      The capitalization of "Person" along with "Thing" leads me to believe that Rosanna may be a key character, especially as Betteredge describes her in great detail compared to the other characters he has introduced thus far. It's interesting that he quips it is "common politeness" to "put the Person before the Thing", when looking at the narrative as a whole, it is the "Thing" which comes before all else. This juxtaposition sets up a dichotomy of the personal versus the objective, which given the format of multiple narrators makes sense.

      Also establishes Betteredge as someone who values social etiquette while subtly hinting that those who are obsessed with the Diamond are somehow indecent. Could that be a jab at the audience as well?

  4. Jun 2016
  5. Jan 2016
    1. The regional brain activation responses to a stimulant drug also differ between controls and cocaine abusers in ventral prefrontal regions. In control subjects, intravenous stimulant administration decreased the activity of ventral medial frontal regions (OFC and ventral ACC), whereas in cocaine abusers, it activated these regions, which are involved in salience attribution and conditioning (Dosenbach et al., 2006, O’Doherty et al., 2001 and Shackman et al., 2011). Activation of the OFC in cocaine abusers was associated with craving (Volkow et al., 2005). In contrast, activity in the right inferior frontal region Ba 44, a key brain region involved in inhibitory control (Aron et al., 2004), was associated with the deactivation of the NAc and ventral PFC upon successful control of cocaine craving (Volkow et al., 2010). This pattern of responses uncovers distinct contributions of PFC regions to addiction on the basis of their striatal projections: dlPFC and inferior frontal regions that project to the dorsal caudate facilitate self-control, whereas ventral PFC regions projecting to NAc facilitate drug taking (Goldstein and Volkow, 2011). This is also consistent with preclinical findings that identified distinct contributions of prelimbic mPFC (PL) and infralimbic mPFC (IL) to cocaine seeking in rats (review in Bossert et al., 2013). Studies using the reinstatement model of relapse found that, after extinction of cocaine self-administration, PL activity promoted cocaine seeking while IL activity inhibited it (Peters et al., 2008). Importantly, in the incubation of the cocaine-craving model (response to cocaine cues progressively increases with time after withdrawal), reversible inactivation of IL, but not PL, decreased “incubated” cue-induced cocaine seeking after prolonged withdrawal, while pharmacological activation of IL, but not PL, increased cocaine seeking during early withdrawal (Koya et al., 2009). However, in the same animal model, optogenetic inhibition of PL neurons (projecting to NAc core) that previously underwent a specific form of cocaine-induced synaptic plasticity (recruitment of silent synapse) decreased incubation of craving, while the opposite effect was observed following inhibition of the IL projection to NAc shell (Di Forti et al., 2014). In clear contrast, in a punishment-induced suppression model of “compulsive” cocaine seeking, in which most rats suppressed cocaine self-administration by shock punishment while a few did not (punishment-resistant “compulsive” rats), optogenetic stimulation of PL inhibited cocaine seeking in punishment-resistant rats while optogenetic inhibition increased it (Chen et al., 2013). However, in the same model, excitotoxic lesions of the PL or IL had no detectable effect on cocaine seeking in punishment-resistant rats (Pelloux et al., 2013). Taken together, the PL and IL appear to play different and complex roles in cocaine-seeking behaviors in rat addiction models, which are highly dependent on the particular behavior being assessed and the experimental procedure used to manipulate local neuronal activity. The results underscore the complexity of the neuroplasticity within the mPFC circuitry, a multimodal brain structure involved in the orchestration of diverse behaviors.